Tin protoporphyrin IX
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Identification
- Generic Name
- Tin protoporphyrin IX
- DrugBank Accession Number
- DB16449
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 785.71
Monoisotopic: 785.051664 - Chemical Formula
- C34H32Cl3N4O4Sn
- Synonyms
- Sn Protoporphyrin
- Sn-heme
- SnPP
- SnPP Protoporphyrin
- Tin protoporphyrin IX
- External IDs
- GTPL5279
- Q27088994
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
SnPP is a competitive inhibitor of heme oxygenase, an enzyme which degrades heme to bilirubin, prevents the development of hyperbilirubinemia, and reduces bilirubin levels in plasma. This compound is also found to directly inactivate DENV and YFV infectious particles and has the potential to have antiviral activity against numerous organisms.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- DIO3JT9G2P
- CAS number
- 14325-05-4
- InChI Key
- KXYSGXXTXAHPIX-UHEVNVKKSA-J
- InChI
- InChI=1S/C34H34N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
- IUPAC Name
- SMILES
- [Cl-].[Cl-].[Sn+4].CC1=C(CCC([O-])=O)/C2=C/C3=N/C(=C\C4=C(C)C(C=C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C=C)=C4C)/C(C)=C3CCC([O-])=O
References
- General References
- Nagae H, Keino H, Watanabe K, Kashiwamata S: Pharmacological and biological effects of tin-protoporphyrin on neonatal hyperbilirubinemic Gunn rats. Pediatr Res. 1988 Aug;24(2):209-12. doi: 10.1203/00006450-198808000-00014. [Article]
- Johnson ACM, Delrow JJ, Zager RA: Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury. Transl Res. 2017 Aug;186:1-18. doi: 10.1016/j.trsl.2017.05.005. Epub 2017 May 19. [Article]
- Pibiri M, Leoni VP, Atzori L: Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy. Life Sci. 2018 Jul 1;204:9-14. doi: 10.1016/j.lfs.2018.05.011. Epub 2018 May 5. [Article]
- Neris RLS, Figueiredo CM, Higa LM, Araujo DF, Carvalho CAM, Vercoza BRF, Silva MOL, Carneiro FA, Tanuri A, Gomes AMO, Bozza MT, Da Poian AT, Cruz-Oliveira C, Assuncao-Miranda I: Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope. Sci Rep. 2018 Jun 28;8(1):9805. doi: 10.1038/s41598-018-27855-7. [Article]
- External Links
- ChemSpider
- 81367143
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Unknown Status Treatment Coronavirus Disease 2019 (COVID‑19) 1 1 Withdrawn Prevention Acute Kidney Injury (AKI) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00596 mg/mL ALOGPS logP 5.67 ALOGPS logS -5.1 ALOGPS Rule of Five No Chemaxon Ghose Filter No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at January 21, 2021 01:43 / Updated at December 23, 2021 07:46