Tin protoporphyrin IX

Identification

Generic Name
Tin protoporphyrin IX
DrugBank Accession Number
DB16449
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 750.26
Monoisotopic: 750.082263
Chemical Formula
C34H32Cl2N4O4Sn
Synonyms
  • Sn Protoporphyrin
  • Sn-heme
  • SnPP
  • SnPP Protoporphyrin
  • Tin protoporphyrin IX
External IDs
  • GTPL5279
  • Q27088994

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Pharmacodynamics

Not Available

Mechanism of action

SnPP is a competitive inhibitor of heme oxygenase, an enzyme which degrades heme to bilirubin, prevents the development of hyperbilirubinemia, and reduces bilirubin levels in plasma. This compound is also found to directly inactivate DENV and YFV infectious particles and has the potential to have antiviral activity against numerous organisms.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
DIO3JT9G2P
CAS number
14325-05-4
InChI Key
HDGCWLZQBOZSGG-UHEVNVKKSA-J
InChI
InChI=1S/C34H34N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
IUPAC Name
dihydrogen 4,20-bis(2-carboxylatoethyl)-10,15-diethenyl-5,9,14,19-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1^{3,6}.1^{8,11}.1^{13,16}]tetracosa-1,3(24),4,6,8,10,12,14,16(22),17,19-undecaene-21,23-diide bis(-lambda2-chloranidyl)stannanetetrakis(ylium)
SMILES
[H+].[H+].[Cl-][Sn+4][Cl-].CC1=C(CCC([O-])=O)/C2=C/C3=N/C(=C\C4=C(C)C(C=C)=C([N-]4)/C=C4\N=C(\C=C\1/[N-]\2)C(C=C)=C4C)/C(C)=C3CCC([O-])=O

References

General References
  1. Nagae H, Keino H, Watanabe K, Kashiwamata S: Pharmacological and biological effects of tin-protoporphyrin on neonatal hyperbilirubinemic Gunn rats. Pediatr Res. 1988 Aug;24(2):209-12. doi: 10.1203/00006450-198808000-00014. [Article]
  2. Johnson ACM, Delrow JJ, Zager RA: Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury. Transl Res. 2017 Aug;186:1-18. doi: 10.1016/j.trsl.2017.05.005. Epub 2017 May 19. [Article]
  3. Pibiri M, Leoni VP, Atzori L: Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy. Life Sci. 2018 Jul 1;204:9-14. doi: 10.1016/j.lfs.2018.05.011. Epub 2018 May 5. [Article]
  4. Neris RLS, Figueiredo CM, Higa LM, Araujo DF, Carvalho CAM, Vercoza BRF, Silva MOL, Carneiro FA, Tanuri A, Gomes AMO, Bozza MT, Da Poian AT, Cruz-Oliveira C, Assuncao-Miranda I: Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope. Sci Rep. 2018 Jun 28;8(1):9805. doi: 10.1038/s41598-018-27855-7. [Article]
ChemSpider
7869395

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingPreventionAcute Kidney Injury (AKI)1
1Active Not RecruitingPreventionAcute Kidney Injury (AKI)1
1CompletedPreventionAcute Kidney Injury (AKI)1
1Not Yet RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
1WithdrawnPreventionAcute Kidney Injury (AKI)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP6.58ChemAxon
pKa (Strongest Acidic)3.79ChemAxon
pKa (Strongest Basic)5.09ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area131.82 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity186.71 m3·mol-1ChemAxon
Polarizability64.4 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on January 21, 2021 01:43 / Updated on January 24, 2021 06:04