NAV

Deoxyribonuclease I

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Deoxyribonuclease I
DrugBank Accession Number
DB16523
Background

Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA71. It is normally found in saliva, urine, pancreatic secretions, and blood1. Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for airway obstruction, abnormal viscoelastic properties of the sputum, and recurrent exacerbations of respiratory symptoms requiring parenteral antibiotics, aerosolized human DNase I has been administered to patients with cystic fibrosis1. Currently, DNase I is being investigated against respiratory failure in COVID-19 in the clinical trial NCT04541979 (Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19).

Type
Biotech
Groups
Investigational
Synonyms
  • DNase I
External IDs
  • Deoxyribonuclease I
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Fuchs HJ, Borowitz DS, Christiansen DH, Morris EM, Nash ML, Ramsey BW, Rosenstein BJ, Smith AL, Wohl ME: Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med. 1994 Sep 8;331(10):637-42. doi: 10.1056/NEJM199409083311003. [Article]
Wikipedia
Deoxyribonuclease_I

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentCoronavirus Disease 2019 (COVID‑19)1
1RecruitingTreatmentCritically Ill Patients / Sepsis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at January 29, 2021 20:58 / Updated at February 13, 2021 10:54