This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Furvina
- DrugBank Accession Number
- DB16547
- Background
Furvina (G1) is an antimicrobial agent active against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi. Furvina is marketed in Cuba as Dermofural®, an ointment containing G1 as the only active principle ingredient. It is used to treat dermatological infections.1
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Furvina (DB16547)
- Weight
- Average: 296.902
Monoisotopic: 294.847969 - Chemical Formula
- C6H3Br2NO3
- Synonyms
- 1-(5-Bromofur-2-yl)-2-bromo-2-nitroethene
- 2-Bromo-5-(2-bromo-2-nitrovinyl)furan
- External IDs
- G 1
- G1
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism U30S ribosomal protein antagonist- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7HFX5XQO7N
- CAS number
- 189935-72-6
- InChI Key
- MJPPGVVIDGQOQT-HWKANZROSA-N
- InChI
- InChI=1S/C6H3Br2NO3/c7-5(9(10)11)3-4-1-2-6(8)12-4/h1-3H/b5-3+
- IUPAC Name
- 2-bromo-5-[(1Z)-2-bromo-2-nitroethenyl]furan
- SMILES
- [O-][N+](=O)C(\Br)=C\C1=CC=C(Br)O1
References
- General References
- Fabbretti A, Brandi L, Petrelli D, Pon CL, Castanedo NR, Medina R, Gualerzi CO: The antibiotic Furvina(R) targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74. doi: 10.1093/nar/gks822. Epub 2012 Aug 31. [Article]
- Allas UL, Toom L, Selyutina A, Maeorg U, Medina R, Merits A, Rinken A, Hauryliuk V, Kaldalu N, Tenson T: Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products. Sci Rep. 2016 Nov 10;6:36844. doi: 10.1038/srep36844. [Article]
- External Links
- ChemSpider
- 4722053
- BindingDB
- 50428795
- ChEMBL
- CHEMBL2335230
- ZINC
- ZINC000000007571
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.63 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 56.28 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 47.67 m3·mol-1 Chemaxon Polarizability 18.99 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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1. 30S ribosomal protein
Unknown
Antagonist
References
- Fabbretti A, Brandi L, Petrelli D, Pon CL, Castanedo NR, Medina R, Gualerzi CO: The antibiotic Furvina(R) targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74. doi: 10.1093/nar/gks822. Epub 2012 Aug 31. [Article]
Drug created at February 04, 2021 17:11 / Updated at February 13, 2021 10:54