This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Furvina
DrugBank Accession Number
DB16547
Background

Furvina (G1) is an antimicrobial agent active against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi. Furvina is marketed in Cuba as Dermofural®, an ointment containing G1 as the only active principle ingredient. It is used to treat dermatological infections.1

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 296.902
Monoisotopic: 294.847969
Chemical Formula
C6H3Br2NO3
Synonyms
  • 1-(5-Bromofur-2-yl)-2-bromo-2-nitroethene
  • 2-Bromo-5-(2-bromo-2-nitrovinyl)furan
External IDs
  • G 1
  • G1

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
U30S ribosomal protein
antagonist
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7HFX5XQO7N
CAS number
189935-72-6
InChI Key
MJPPGVVIDGQOQT-HWKANZROSA-N
InChI
InChI=1S/C6H3Br2NO3/c7-5(9(10)11)3-4-1-2-6(8)12-4/h1-3H/b5-3+
IUPAC Name
2-bromo-5-[(1Z)-2-bromo-2-nitroethenyl]furan
SMILES
[O-][N+](=O)C(\Br)=C\C1=CC=C(Br)O1

References

General References
  1. Fabbretti A, Brandi L, Petrelli D, Pon CL, Castanedo NR, Medina R, Gualerzi CO: The antibiotic Furvina(R) targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74. doi: 10.1093/nar/gks822. Epub 2012 Aug 31. [Article]
  2. Allas UL, Toom L, Selyutina A, Maeorg U, Medina R, Merits A, Rinken A, Hauryliuk V, Kaldalu N, Tenson T: Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products. Sci Rep. 2016 Nov 10;6:36844. doi: 10.1038/srep36844. [Article]
ChemSpider
4722053
BindingDB
50428795
ChEMBL
CHEMBL2335230
ZINC
ZINC000000007571

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP2.63ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area56.28 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity47.67 m3·mol-1ChemAxon
Polarizability18.99 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Drugtargets2
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1. 30S ribosomal protein
Kind
Group
Organism
Not Available
Pharmacological action
Unknown
Actions
Antagonist
Curator comments
In vitro and in vivo experiments using Escherichia coli suggest that furvina can bind at or near the P-site of the bacterial 30S ribosome and inhibit translation initiation.
Group which encompasses the subunits of the 30S ribosomal protein not specific to any organism.
References
  1. Fabbretti A, Brandi L, Petrelli D, Pon CL, Castanedo NR, Medina R, Gualerzi CO: The antibiotic Furvina(R) targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74. doi: 10.1093/nar/gks822. Epub 2012 Aug 31. [Article]

Drug created at February 04, 2021 17:11 / Updated at February 13, 2021 10:54