Setanaxib

DB16869InvestigationalSmall molecule

Setanaxib: Overview.

Mechanism: Pharmacologically active on NADPH oxidase 1 and NADPH oxidase 4
Curator reviewed
Formula / weight: C₂₁H₁₉ClN₄O₂ · 394.86 g/mol (avg)
Also known as: 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-C]pyridine-3,6(2H,5H)-dione
Code names: GKT-137831 · GKT-831

Resolves to

Compound

Structure

InChIKeyRGYQPQARIQKJKH-UHFFFAOYSA-NSMILESCN(C)C1=CC(=CC=C1)C1=C2C(NN(C2=O)C2=CC=CC=C2Cl)=CC(=O)N1C

Targets

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

7Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Setanaxib, and which of those have an active Phase 3 trial?

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