ENMD-981693

DB16891InvestigationalSmall molecule

ENMD-981693: Overview.

Mechanism: Pharmacologically active on Receptor-type tyrosine-protein kinase FLT3, Vascular endothelial growth factor receptor 2, and Mast/stem cell growth factor receptor Kit
Curator reviewed
Formula / weight: C₂₁H₂₅N₇ · 375.48 g/mol (avg)
Also known as: (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine
Code names: ENMD-981693 · R-440 · RO-317453

Resolves to

Compound

Structure

InChIKeyBLQYVHBZHAISJM-CMDGGOBGSA-NSMILESCN1CCN(CC1)C1=CC(NC2=NNC(C)=C2)=NC(\C=C\C2=CC=CC=C2)=N1

Targets

What you can answer from here — as of August 30, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

8Clinical trialsPhase, status and sponsor resolved per trial

31+ReferencesStructured and connected to the statements they support

Which drugs share a target with ENMD-981693, and which of those have an active Phase 3 trial?

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