This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Ioflupane F-18
- DrugBank Accession Number
- DB16913
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Ioflupane F-18 (DB16913)
- Weight
- Average: 430.292
Monoisotopic: 430.07829 - Chemical Formula
- C18H23FINO2
- Synonyms
- (18f)fp-cit
- 18f-beta-cit-fp
- 18f-cit-fp
- 18f-fp-.beta.-cit
- 18f-fpcit
- 18f-ioflupane
- 18fluorine-n-3-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane
- 8-azabicyclo(3.2.1)octane-2-carboxylic acid, 8-(3-(fluoro-18f)propyl)-3-(4-iodophenyl)-, methyl ester, (1r,2s,3s,5s)-
- F-18-fpcit
- Methyl (1s,3s,4s,5r)-8-(3-fluoranylpropyl)-3-(4-iodophenyl)-8-azabicyclo(3.2.1)octane-4-carboxylate
- External IDs
- FP-CIT F-18
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- NT4P0L3OCX
- CAS number
- 186381-69-1
- InChI Key
- HXWLAJVUJSVENX-LNYNZGDVSA-N
- InChI
- InChI=1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14-,15+,16+,17-/m0/s1/i19-1
- IUPAC Name
- methyl (1R,2S,3S,5S)-8-[3-(¹⁸F)fluoropropyl]-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
- SMILES
- [H][C@]12CC[C@]([H])([C@H]([C@H](C1)C1=CC=C(I)C=C1)C(=O)OC)N2CCC[18F]
References
- General References
- Not Available
- External Links
- ChemSpider
- 9800875
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Diagnostic Parkinson's Disease (PD) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00566 mg/mL ALOGPS logP 4.24 ALOGPS logP 3.7 Chemaxon logS -4.9 ALOGPS pKa (Strongest Basic) 9.46 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 29.54 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 97.34 m3·mol-1 Chemaxon Polarizability 38.86 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at September 12, 2022 21:25 / Updated at December 01, 2022 11:32