ABT-737

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DB17023ExperimentalSmall molecule

An inhibitor of members of the Bcl‑2 family of apoptosis regulators.

Formula / weight: C₄₂H₄₅ClN₆O₅S₂ · 813.43 g/mol (avg)
Also known as: Benzamide, 4-(4-((4'-chloro(1,1'-biphenyl)-2-yl)methyl)-1-piperazinyl)-n-((4-(((1r)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)-
Code names: ABT-737

Resolves to

Compound

UNIIZ5NFR173NVCAS852808-04-9ChEMBLCHEMBL376408ChEBI47575

Structure

InChIKeyHPLNQCPCUACXLM-PGUFJCEWSA-NSMILESCN(C)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(C=C1[N+]([O-])=O)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC2=CC=CC=C2C2=CC=C(Cl)C=C2)CC1

Targets

P10415BCL2

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with ABT-737, and which of those have an active Phase 3 trial?

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