SB-218078

DB17051ExperimentalSmall molecule

SB-218078 is a specific inhibitor of CHK1.

Chemical structure of SB-218078
Formula / weight
C24H15N3O3 · 393.402 g/mol (avg)
Also known as
9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2h)-dione · 9,12-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2h)-dione, 9,10,11,12-tetrahydro-
Code names
SB-218078

Resolves to

Compound
UNIIS6U3J3UP11CAS135897-06-2ChEMBLCHEMBL304428ChEBI91500
Structure
InChIKeyOTPNDVKVEAIXTI-UHFFFAOYSA-NSMILESO=C1NC(=O)C2=C1C1=C3N(C4CCC(O4)N4C5=C(C=CC=C5)C2=C34)C2=C1C=CC=C2
Targets
O14757CHEK1

What you can answer from here — as of July 17, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
2+ReferencesStructured and connected to the statements they support
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