SB 224289

DB17052ExperimentalSmall molecule

SB-224289 is a small molecule with a high affinity for human 5-HT1B receptors.

Formula / weight: C₃₂H₃₂N₄O₃ · 520.633 g/mol (avg)
Also known as: (1'-methyl-6,7-dihydro-5h-spiro(furo(2,3-f)indole-3,4'-piperidin)-5-yl)(2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methanone · (2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-yl)(1'-methyl-6,7-dihydrospiro(furo(2,3-f)indole-3,4'-piperidin)-5(2h)-yl)methanone · (4-(2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)phenyl)-(1'-methylspiro(6,7-dihydro-2h-furo(2,3-f)indole-3,4'-piperidine)-5-yl)methanone · 6,7-dihydro-1'-methyl-5-((2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-yl)carbonyl)spiro(2h-furo(2,3-f)indole-3(5h),4'-piperidine) · Methanone, (2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1'-biphenyl)-4-yl)(2,5,6,7-tetrahydro-1'-methylspiro(3h-furo(2,3-f)indole-3,4'-piperidin)-5-yl)-
Code names: J854.001B · SB-224289

Resolves to

Compound

Structure

InChIKeyATQMRMGXINTJHV-UHFFFAOYSA-NSMILESCN1CCC2(COC3=CC4=C(C=C23)N(CC4)C(=O)C2=CC=C(C=C2)C2=C(C)C=C(C=C2)C2=NOC(C)=N2)CC1

Targets

What you can answer from here — as of July 17, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with SB 224289, and which of those have an active Phase 3 trial?

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