Spiperone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Spiperone
DrugBank Accession Number
DB17056
Background

Spiperone is a dopamine antagonist that binds dopamine and serotonin receptors.1

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 395.478
Monoisotopic: 395.200905252
Chemical Formula
C23H26FN3O2
Synonyms
  • Spiropitan
External IDs
  • NSC-170983
  • R 5147
  • R-5147

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Spiperone hydrochlorideNot Available2022-29-9Not applicable

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
4X6E73CJ0Q
CAS number
749-02-0
InChI Key
DKGZKTPJOSAWFA-UHFFFAOYSA-N
InChI
InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
IUPAC Name
8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
SMILES
FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1

References

General References
  1. Dannies PS, Rudnick MS, Fishkes H, Rudnick G: Spiperone: evidence for uptake into secretory granules. Proc Natl Acad Sci U S A. 1984 Mar;81(6):1867-70. doi: 10.1073/pnas.81.6.1867. [Article]
Human Metabolome Database
HMDB0258423
ChemSpider
5075
BindingDB
21397
ChEBI
9233
ChEMBL
CHEMBL267930
ZINC
ZINC000000643233
PDBe Ligand
SIP
Wikipedia
Spiperone
PDB Entries
7dfp

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.163 mg/mLALOGPS
logP2.86ALOGPS
logP3.07Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)11.83Chemaxon
pKa (Strongest Basic)8.28Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area52.65 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity111.19 m3·mol-1Chemaxon
Polarizability42.95 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at October 11, 2022 18:55 / Updated at December 13, 2022 10:46