TK216

DB17414InvestigationalSmall molecule

TK216: Overview.

Mechanism: Pharmacologically active on Tubulin alpha-1B chain, Friend leukemia integration 1 transcription factor, and RNA-binding protein EWS
Curator reviewed
Formula / weight: C₁₉H₁₅Cl₂NO₃ · 376.23 g/mol (avg)
Code names: ONCT-216 · TK-216

Resolves to

Compound

Structure

InChIKeyZWHNLSHDLKIXOG-UHFFFAOYSA-NSMILESOC1=NC2=C(Cl)C=CC(Cl)=C2C1(O)CC(=O)C1=CC=C(C=C1)C1CC1

Targets

What you can answer from here — as of July 08, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

12+ReferencesStructured and connected to the statements they support

Which drugs share a target with TK216, and which of those have an active Phase 3 trial?

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