Aphidicolin

DB17742ExperimentalSmall molecule

Aphidicolin is an antimitotic and antiviral metabolite of the mould Cephalosporium aphidicola. It inhibits DNA polymerase alpha and blocks DNA replication.

Chemical structure of Aphidicolin
Formula / weight
C20H34O4 · 338.488 g/mol (avg)
Also known as
(+)-aphidicolin · 8,11a-methano-11ah-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3r,4r,4ar,6as,8r,9r,11as,11bs)- · 9,15-cyclo-c,18-dinor-14,15-secoandrostane-4,17-dimethanol, 3,17-dihydroxy-4-methyl-, (3.alpha.,4.alpha.,5.alpha.,17.alpha.)-
Code names
ICI-69653 · NSC-234714

Resolves to

Compound
UNII192TJ6PP19CAS38966-21-1ChEMBLCHEMBL29711ChEBI2766
Structure
InChIKeyNOFOAYPPHIUXJR-APNQCZIXSA-NSMILES[H][C@]12C[C@@H]3C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CC[C@@H](O)[C@@](C)(CO)[C@]1([H])CC2
Targets
P04293DNA polymerase catalytic subunit

What you can answer from here — as of March 06, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
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3+ReferencesStructured and connected to the statements they support
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