Inupadenant

DB19129InvestigationalSmall molecule

Inupadenant is under investigation in clinical trial NCT05060432 (Study of EOS-448 With Standard of Care And/or Investigational Therapies in Participants With Advanced Solid Tumors).

Formula / weight: C₂₅H₂₆F₂N₈O₄S₂ · 604.65 g/mol (avg)
Also known as: (+)-5-amino-3-(2-(4-(2,4-difluoro-5-(2-((s)-methanesulfinyl)ethoxy)phenyl)piperazin-1- yl)ethyl)-8-(furan-2-yl)thiazolo(5,4-e)(1,2,4)triazolo(1,5-c)pyrimidin-2(3h)-one · Thiazolo(5,4-e)(1,2,4)triazolo(1,5-c)pyrimidin-2(3h)-one, 5-amino-3-(2-(4-(2,4-difluoro-5-(2-((s)-methylsulfinyl)ethoxy)phenyl)-1-piperazinyl)ethyl)-8-(2-furanyl)- · Thiazolo(5,4-e)(1,2,4)triazolo(1,5-c)pyrimidin-2(3h)-one, 5-amino-3-(2-(4-(2,4-difluoro-5-(2-(methylsulfinyl)ethoxy)phenyl)-1-piperazinyl)ethyl)-8-(2-furanyl)-, (+)-
Code names: EOS-100850

Resolves to

Compound

UNIIHQ700V0X06CAS2246607-08-7ChEMBLCHEMBL4650331

Structure

InChIKeyQYCCLUSYHJXDEX-RWYGWLOXSA-NSMILESC[S@+]([O-])CCOC1=CC(N2CCN(CCN3C(=O)SC4=C3N=C(N)N3N=C(N=C43)C3=CC=CO3)CC2)=C(F)C=C1F

Targets

P29274ADORA2A

What you can answer from here — as of April 23, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Inupadenant, and which of those have an active Phase 3 trial?

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