Frespaciguat

DB21683InvestigationalSmall molecule

Frespaciguat is a small molecule drug. The usage of the INN stem '-ciguat' in the name indicates that Frespaciguat is a guanylate cyclase activator and stimulator. Frespaciguat is under investigation... Frespaciguat is under investigation in clinical trial NCT05612035 (Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD).

Mechanism: Pharmacologically active on Guanylate cyclase
Curator reviewed
Formula / weight: C₂₇H₂₂ClF₅N₆O₃ · 608.95 g/mol (avg)
Code names: MK-5475

Resolves to

Compound

UNII6DXN080KGBCAS2101645-33-2ChEMBLCHEMBL5944803ChEBI759873PubChem129242560

Structure

InChIKeyBAFUFNSAYGCZIC-VWLOTQADSA-NSMILESC[C@]1(C(=O)NC2=NC(=NC(N)=C12)C1=NN(CCC(F)(F)C(F)(F)F)C2=CC(Cl)=CC=C12)C1=CC=C(CCC(O)=O)C=C1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

6Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which companies are running trials of Frespaciguat, in which indications and phases, and which of those programs are still active?

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