Orca-T is a donor-derived, three-component allogeneic cell therapy (HSPCs / regulatory T cells / conventional T cells) for matched-donor myeloablative stem cell transplantation in adults with hematological malignancies to improve chronic GVHD-free survival. It is a precision-engineered graft composed of three cell populations isolated from an HLA-matched donor's mobilized peripheral blood — purified hematopoietic stem and progenitor cells (HSPCs), regulatory T cells (Tregs), and conventional T cells (Tcons)...
- Mechanism
- Curator reviewed · 5 references
Orca-T contains purified regulatory T cells (Tregs), conventional T cells (Tcons) and allogeneic hematopoietic stem and progenitor cells (HSPCs) isolated from the mobilized peripheral blood of an HLA-matched donor. Tregs are administered before Tcons to control graft-versus-host disease (GVHD) and promote immune reconstitution. Nonclinical studies have shown that Tregs suppress Tcon activation and proliferation in secondary lymphoid organs and GVHD target organs and improve immune reconstitution without compromising the graft-versus-tumor effects of Tcons. Tcons are administered approximately two days later to accelerate immune reconstitution, which is thought to result in graft-versus-infection and graft-versus-leukemia effects. The HSPCs home to the bone marrow, engraft, self-renew, proliferate and differentiate into all mature blood cells, which circulate in the blood and migrate to tissue sites, restoring blood counts and hematopoietic function.
- Primary indication
- Orca-T is indicated for use in matched donor hematopoietic stem cell transplantation with myeloablative preparative regimen, for hematopoietic and immunologic reconstitution and to improve chronic graft-versus-host disease-free survival, in the treatment of adults with hematological...Curator reviewed · 2 structured indications
- Also known as
- Allogeneic regulatory T cell immunotherapy with HSPC and T cells-vldq · TregGraft
- Code names
- TRGFT-201
Resolves to
What you can answer from here — as of November 02, 2026
Which other approved drugs treat the same conditions as Orca-T, and which companies have late-stage candidates in those indications?
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