FRAX597

DB31734ExperimentalSmall molecule

FRAX597 is a small molecule drug that inhibits the p21-activated kinases (PAKs).

Mechanism: FRAX597 is a potent ATP-competitive inhibitor of the group I p21-activated kinases (PAKs) which includes PAK1, PAK2, and PAK3.
Curator reviewed · 2 references
Formula / weight: C₂₉H₂₈ClN₇OS · 558.1 g/mol (avg)
Code names: FRAX597

Resolves to

Compound

Structure

InChIKeyDHUJCQOUWQMVCG-UHFFFAOYSA-NSMILESCCN1C(=O)C(=CC2=CN=C(NC3=CC=C(C=C3)N3CCN(C)CC3)N=C12)C1=C(Cl)C=C(C=C1)C1=CN=CS1

Targets

What you can answer from here — as of August 31, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with FRAX597, and which of those have an active Phase 3 trial?

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