SI-109

DB32603ExperimentalSmall molecule

SI-109 is a potent, small-molecule inhibitor of the STAT3 SH2 domain.

Mechanism: Pharmacologically active on Signal transducer and activator of transcription 3
Curator reviewed
Formula / weight: C₄₀H₄₄F₂N₇O₉P · 835.803 g/mol (avg)
Code names: SI-109

Resolves to

Compound

Structure

CC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)C1=CC2=C(N1)C=CC(=C2)C(F)(F)P(O)(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1

Targets

What you can answer from here — as of August 31, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with SI-109, and which of those have an active Phase 3 trial?

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