Ropinirole HydrochlorideProduct ingredient for Ropinirole

Name
Ropinirole Hydrochloride
Drug Entry
Ropinirole

Ropinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome Label, 3. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA Label for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome 3.

In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole 4.

Accession Number
DBSALT000390
Structure
Synonyms
Ropinirole HCl
UNII
D7ZD41RZI9
CAS Number
91374-20-8
Weight
Average: 296.836
Monoisotopic: 296.165541139
Chemical Formula
C16H25ClN2O
InChI Key
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
InChI
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
IUPAC Name
4-[2-(dipropylamino)ethyl]-3H-indol-2-ol hydrochloride
SMILES
Cl.CCCN(CCC)CCC1=C2CC(O)=NC2=CC=C1
PubChem Compound
68727
ChemSpider
61977
ChEBI
8889
ChEMBL
CHEMBL1200411
Wikipedia
Ropinirole
Predicted Properties
PropertyValueSource
Water Solubility0.118 mg/mLALOGPS
logP3.24ALOGPS
logP1.06Chemaxon
logS-3.3ALOGPS
pKa (Strongest Acidic)4.99Chemaxon
pKa (Strongest Basic)10.28Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area35.83 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity82.18 m3·mol-1Chemaxon
Polarizability31.32 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon