Ropinirole HydrochlorideProduct ingredient for Ropinirole
- Name
- Ropinirole Hydrochloride
- Drug Entry
- Ropinirole
Ropinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome Label, 3. It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA Label for the management of Parkinson's disease. In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless legs syndrome 3.
In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing, therefore increased compliance, and offering a similar side effect profile and efficacy to previous formulations of ropinirole 4.
- Accession Number
- DBSALT000390
- Structure
- Synonyms
- Ropinirole HCl
- UNII
- D7ZD41RZI9
- CAS Number
- 91374-20-8
- Weight
- Average: 296.836
Monoisotopic: 296.165541139 - Chemical Formula
- C16H25ClN2O
- InChI Key
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
- IUPAC Name
- 4-[2-(dipropylamino)ethyl]-3H-indol-2-ol hydrochloride
- SMILES
- Cl.CCCN(CCC)CCC1=C2CC(O)=NC2=CC=C1
- External Links
- PubChem Compound
- 68727
- ChemSpider
- 61977
- ChEBI
- 8889
- ChEMBL
- CHEMBL1200411
- Wikipedia
- Ropinirole
- Predicted Properties
Property Value Source Water Solubility 0.118 mg/mL ALOGPS logP 3.24 ALOGPS logP 1.06 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 4.99 Chemaxon pKa (Strongest Basic) 10.28 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 35.83 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 82.18 m3·mol-1 Chemaxon Polarizability 31.32 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon