Promethazine hydrochlorideProduct ingredient for Promethazine

Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946.¹ Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.^2,8,9,7,10

Promethazine was granted FDA approval before 29 March 1951.^11,12