Rabeprazole sodiumProduct ingredient for Rabeprazole
- Name
- Rabeprazole sodium
- Drug Entry
- Rabeprazole
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
- Accession Number
- DBSALT000552
- Structure
- Synonyms
- Not Available
- UNII
- 3L36P16U4R
- CAS Number
- 117976-90-6
- Weight
- Average: 381.424
Monoisotopic: 381.112306886 - Chemical Formula
- C18H20N3NaO3S
- InChI Key
- KRCQSTCYZUOBHN-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1
- IUPAC Name
- sodium 2-{[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methanesulfinyl}-1H-1,3-benzodiazol-1-ide
- SMILES
- [Na+].COCCCOC1=CC=NC(CS(=O)C2=NC3=CC=CC=C3[N-]2)=C1C
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.427 mg/mL ALOGPS logP 1.88 ALOGPS logP 2.09 Chemaxon logS -3 ALOGPS pKa (Strongest Acidic) 9.35 Chemaxon pKa (Strongest Basic) 4.24 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 74.2 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 98.68 m3·mol-1 Chemaxon Polarizability 39.2 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon