Pirbuterol hydrochlorideProduct ingredient for Pirbuterol
- Name
- Pirbuterol hydrochloride
- Drug Entry
- Pirbuterol
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
- Accession Number
- DBSALT000798
- Structure
Structure for Pirbuterol hydrochloride (DBSALT000798)
- Synonyms
- Pirbuterol HCl
- UNII
- GR436K4GK8
- CAS Number
- 38029-10-6
- Weight
- Average: 276.76
Monoisotopic: 276.124070255 - Chemical Formula
- C12H21ClN2O3
- InChI Key
- GPDAJAWUGSTOSA-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H20N2O3.ClH/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8;/h4-5,11,13,15-17H,6-7H2,1-3H3;1H
- IUPAC Name
- 6-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol hydrochloride
- SMILES
- Cl.CC(C)(C)NCC(O)C1=NC(CO)=C(O)C=C1
- External Links
- PubChem Compound
- 3061720
- ChemSpider
- 2322503
- ChEMBL
- CHEMBL1997417
- Predicted Properties
Property Value Source Water Solubility 6.22 mg/mL ALOGPS logP 0.38 ALOGPS logP -0.66 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 8.79 Chemaxon pKa (Strongest Basic) 9.59 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 85.61 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 64.74 m3·mol-1 Chemaxon Polarizability 26.05 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon