Thiopental sodiumProduct ingredient for Thiopental
- Name
- Thiopental sodium
- Drug Entry
- Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)
- Accession Number
- DBSALT001409
- Structure
- Synonyms
- Not Available
- UNII
- 49Y44QZL70
- CAS Number
- 71-73-8
- Weight
- Average: 264.32
Monoisotopic: 264.09084325 - Chemical Formula
- C11H17N2NaO2S
- InChI Key
- AWLILQARPMWUHA-UHFFFAOYSA-M
- InChI
- InChI=1S/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1
- IUPAC Name
- sodium 5-ethyl-6-hydroxy-5-(pentan-2-yl)-2-sulfanylidene-2,5-dihydropyrimidin-4-olate
- SMILES
- [Na+].CCCC(C)C1(CC)C(O)=NC(=S)N=C1[O-]
- External Links
- ChemSpider
- 2272257
- ChEBI
- 9561
- ChEMBL
- CHEMBL738
- Wikipedia
- Sodium_thiopental
- Predicted Properties
Property Value Source Water Solubility 0.049 mg/mL ALOGPS logP 2.95 ALOGPS logP 3.52 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 2.08 Chemaxon pKa (Strongest Basic) -6.2 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 68.01 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 77.19 m3·mol-1 Chemaxon Polarizability 25.23 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon