Acromegaly

Also known as: Acromegalic / Acromegaly (disorder) / (Acromegaly &/or gigantism) or (pituitary hyperfunction, ant.) / Overproduction of growth hormone / Acromegaly and gigantism / Gigantism and acromegaly (disorder) / Gigantism and acromegaly (& [growth hormone overproduction]) / Anterior pituitary hyperfunction / Hyperpituitarism / Hyperpituitarism NOS / Hyperpituitarism (disorder) / Hypersomatotropic gigantism (disorder) / Giant -RETIRED- / Gigantism / Gigantism (disorder)

DrugDrug NameDrug Description
DB01200BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
DB06791LanreotideA somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.
DB00104OctreotideA peptide drug used to treat acromegaly as well as diarrhea associated with metastatic carcinoid tumors and vasoactive intestinal peptide secreting tumors.
DB06663PasireotideA somatostatin analog used in the treatment of Cushing’s disease, specifically for those patients whom pituitary surgery is not appropriate.
DB00082PegvisomantA growth hormone receptor antagonist used to treat acromegaly.
DB09099SomatostatinA natural peptide hormone used to treat acute bleeding from esophageal varices, gastrointestinal ulcers, and gastritis; prevent pancreatic complications after surgery; and restrict secretions of the upper intestine, pancreas, and biliary tract.
DrugDrug NameTargetType
DB01200BromocriptineDopamine D2 receptortarget
DB01200BromocriptineCytochrome P450 3A4enzyme
DB01200Bromocriptine5-hydroxytryptamine receptor 1Dtarget
DB01200BromocriptineAlpha-2A adrenergic receptortarget
DB01200BromocriptineDopamine D3 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Atarget
DB01200BromocriptineAlpha-2C adrenergic receptortarget
DB01200BromocriptineAlpha-2B adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Btarget
DB01200BromocriptineDopamine D4 receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Atarget
DB01200Bromocriptine5-hydroxytryptamine receptor 1Btarget
DB01200Bromocriptine5-hydroxytryptamine receptor 2Ctarget
DB01200BromocriptineDopamine D5 receptortarget
DB01200BromocriptineDopamine D1 receptortarget
DB01200BromocriptineAlpha-1A adrenergic receptortarget
DB01200BromocriptineAlpha-1B adrenergic receptortarget
DB01200BromocriptineAlpha-1D adrenergic receptortarget
DB01200Bromocriptine5-hydroxytryptamine receptor 7target
DB01200BromocriptineP-glycoprotein 1transporter
DB06791LanreotideSomatostatin receptor type 2target
DB06791LanreotideSomatostatin receptor type 5target
DB06791LanreotideCytochrome P450 3A4enzyme
DB00104OctreotideMyeloperoxidaseenzyme
DB00104OctreotideCytochrome P450 3A4enzyme
DB00104OctreotideSomatostatin receptortarget
DB00104OctreotideSerum albumincarrier
DB00104OctreotideP-glycoprotein 1transporter
DB00104OctreotideCanalicular multispecific organic anion transporter 1transporter
DB06663PasireotideSomatostatin receptor type 1target
DB06663PasireotideSomatostatin receptor type 2target
DB06663PasireotideSomatostatin receptor type 3target
DB06663PasireotideSomatostatin receptor type 5target
DB06663PasireotideCytochrome P450 3A4enzyme
DB00082PegvisomantGrowth hormone receptortarget
DB00082PegvisomantSterol 26-hydroxylase, mitochondrialenzyme
DB00082PegvisomantGlutamine synthetaseenzyme
DB00082PegvisomantCytochrome P450 3A4enzyme
DB00082PegvisomantCholinesteraseenzyme
DB00082PegvisomantCytochrome P450 4A11enzyme
DB09099SomatostatinSomatostatin receptor type 1target
DB09099SomatostatinSomatostatin receptor type 2target
DB09099SomatostatinSomatostatin receptor type 3target
DB09099SomatostatinSomatostatin receptor type 4target
DB09099SomatostatinSomatostatin receptor type 5target
DB09099SomatostatinP-glycoprotein 1transporter
DB09099SomatostatinCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00169Cholecalciferol1Recruiting1
DB06791Lanreotide1Not Yet Recruiting1
DB00104Octreotide1Not Yet Recruiting1
DB00104Octreotide1Suspended1
DB00104Octreotide1Terminated1
DB06663Pasireotide1Completed1
DB06791Lanreotide1 / 2Completed1
DB00882Clomifene2Completed1
DB16144Dopastatin2Terminated1
DB06791Lanreotide2Unknown Status1
DB06791Lanreotide2Withdrawn1
DB00104Octreotide2Completed7
DB16277Paltusotine2Completed2
DB16277Paltusotine2Enrolling by Invitation1
DB06663Pasireotide2Completed3
DB12777Somatoprim2Completed2
DB09099Somatostatin2Completed1
DB06791Lanreotide2 / 3Completed1
DB06791Lanreotide3Completed8
DB00104Octreotide3Active Not Recruiting1
DB00104Octreotide3Completed8
DB00104Octreotide3Recruiting2
DB00104Octreotide3Terminated3
DB16277Paltusotine3Recruiting2
DB06663Pasireotide3Completed3
DB00082Pegvisomant3Completed3
DB09099Somatostatin3Terminated1
DB00248Cabergoline4Active Not Recruiting1
DB00248Cabergoline4Completed3
DB00988Dopamine4Completed1
DB00030Insulin human4Completed1
DB06791Lanreotide4Completed5
DB06791Lanreotide4Terminated1
DB06655Liraglutide4Completed1
DB00331Metformin4Completed1
DB00104Octreotide4Completed11
DB00104Octreotide4Terminated1
DB00104Octreotide4Unknown Status2
DB06663Pasireotide4Active Not Recruiting1
DB06663Pasireotide4Completed1
DB06663Pasireotide4Unknown Status1
DB00082Pegvisomant4Completed7
DB00082Pegvisomant4Unknown Status2
DB01261Sitagliptin4Completed1
DB09099Somatostatin4Completed1
DB00316AcetaminophenNot AvailableNot Yet Recruiting1
DB00248CabergolineNot AvailableCompleted1
DB09038EmpagliflozinNot AvailableRecruiting1
DB00695FurosemideNot AvailableCompleted1
DB12091GadoliniumNot AvailableCompleted1
DB06791LanreotideNot AvailableCompleted3
DB06791LanreotideNot AvailableRecruiting2
DB06791LanreotideNot AvailableTerminated1
DB00104OctreotideNot AvailableCompleted4
DB00104OctreotideNot AvailableRecruiting2
DB06663PasireotideNot AvailableApproved for Marketing1
DB00082PegvisomantNot AvailableCompleted4
DB00082PegvisomantNot AvailableNot Yet Recruiting1
DB00082PegvisomantNot AvailableRecruiting1
DB09099SomatostatinNot AvailableCompleted2
DB00052SomatotropinNot AvailableCompleted2
DB00052SomatotropinNot AvailableRecruiting1