Refractory Anemia With Excess of Blasts (RAEB)

Also known as: Myelodysplastic Syndrome-Refractory Anemia With Excess Blasts / RAEB / Refractory anemia with an excess of blasts / MDS-refractory anemia with excess blasts (RAEB) / Anemia, Refractory, With Excess of Blasts / Refractory anaemia with an excess of blasts / Refractory Anemia With Excess Blasts / Myelodysplastic syndrome with excess blasts / Refractory anemia with excess of blasts [RAEB] / Refractory anemia with excess of blasts, unspecified / Myelodysplastic syndrome with excess blasts (disorder) / Myelodysplastic syndrome with increased blasts (morphologic abnormality)

Drug	Drug Name	Drug Description
DB00928	Azacitidine	A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.
DB15694	Cedazuridine	A cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS).
DB01262	Decitabine	A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression.

Drug	Drug Name	Target	Type
DB00928	Azacitidine	DNA (cytosine-5)-methyltransferase 1	target
DB00928	Azacitidine	Cytidine deaminase	enzyme
DB00928	Azacitidine	DNA	target
DB00928	Azacitidine	RNA	target
DB15694	Cedazuridine	Cytidine deaminase	target
DB01262	Decitabine	DNA	target
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 1	target
DB01262	Decitabine	Deoxycytidine kinase	enzyme
DB01262	Decitabine	UMP-CMP kinase	enzyme
DB01262	Decitabine	Nucleoside diphosphokinase	enzyme
DB01262	Decitabine	Cytidine deaminase	enzyme
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 3A	target
DB01262	Decitabine	DNA (cytosine-5)-methyltransferase 3B	target
DB01262	Decitabine	Sodium/nucleoside cotransporter 1	transporter
DB01262	Decitabine	Histone deacetylase	target

Drug	Drug Name	Phase	Status	Count
DB03496	Alvocidib	1	Completed	1
DB12234	BMS-214662	1	Completed	1
DB06362	Becatecarin	1	Completed	1
DB00188	Bortezomib	1	Completed	1
DB00531	Cyclophosphamide	1	Completed	1
DB00531	Cyclophosphamide	1	Terminated	1
DB00091	Cyclosporine	1	Completed	4
DB01073	Fludarabine	1	Completed	4
DB01073	Fludarabine	1	Terminated	1
DB11659	Indium	1	Completed	1
DB06188	Ispinesib	1	Completed	1
DB00480	Lenalidomide	1	Completed	1
DB00688	Mycophenolate mofetil	1	Completed	4
DB00688	Mycophenolate mofetil	1	Terminated	1
DB14729	Rebeccamycin	1	Completed	1
DB00864	Tacrolimus	1	Terminated	1
DB04960	Tipifarnib	1	Completed	1
DB02546	Vorinostat	1	Completed	1
DB00041	Aldesleukin	1 / 2	Completed	1
DB02379	Beta-D-Glucose	1 / 2	Terminated	1
DB01008	Busulfan	1 / 2	Terminated	1
DB00531	Cyclophosphamide	1 / 2	Withdrawn	1
DB00987	Cytarabine	1 / 2	Completed	1
DB00694	Daunorubicin	1 / 2	Completed	1
DB01262	Decitabine	1 / 2	Completed	1
DB00773	Etoposide	1 / 2	Terminated	1
DB01073	Fludarabine	1 / 2	Withdrawn	1
DB01177	Idarubicin	1 / 2	Completed	1
DB17475	Incomplete Freund's adjuvant	1 / 2	Completed	1
DB00563	Methotrexate	1 / 2	Terminated	1
DB15276	PR1 leukemia peptide vaccine	1 / 2	Completed	1
DB00020	Sargramostim	1 / 2	Completed	1
DB06436	Semaxanib	1 / 2	Completed	1
DB17459	Therapeutic allogeneic lymphocytes	1 / 2	Completed	1
DB04960	Tipifarnib	1 / 2	Completed	1
DB02594	2'-Deoxycytidine	2	Terminated	1
DB08870	Brentuximab vedotin	2	Completed	1
DB01008	Busulfan	2	Recruiting	1
DB00631	Clofarabine	2	Completed	1
DB06189	Clofarabine	2	Completed	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Completed	1
DB00091	Cyclosporine	2	Completed	3
DB00091	Cyclosporine	2	Recruiting	1
DB00091	Cyclosporine	2	Terminated	1
DB00987	Cytarabine	2	Completed	1
DB00987	Cytarabine	2	Terminated	1
DB01262	Decitabine	2	Terminated	1
DB18722	Dilanubicel	2	Completed	1
DB11841	Entinostat	2	Completed	1
DB00099	Filgrastim	2	Completed	1
DB00099	Filgrastim	2	Recruiting	1
DB01073	Fludarabine	2	Active Not Recruiting	1
DB01073	Fludarabine	2	Completed	2
DB01073	Fludarabine	2	Recruiting	1
DB01073	Fludarabine	2	Terminated	1
DB01177	Idarubicin	2	Terminated	1
DB01042	Melphalan	2	Recruiting	1
DB14123	Menthol	2	Completed	1
DB00563	Methotrexate	2	Completed	1
DB00688	Mycophenolate mofetil	2	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	2	Completed	2
DB00688	Mycophenolate mofetil	2	Recruiting	1
DB00688	Mycophenolate mofetil	2	Terminated	1
DB01024	Mycophenolic acid	2	Active Not Recruiting	1
DB00020	Sargramostim	2	Completed	1
DB00864	Tacrolimus	2	Active Not Recruiting	1
DB00864	Tacrolimus	2	Completed	1
DB06287	Temsirolimus	2	Completed	1
DB01041	Thalidomide	2	Completed	1
DB02546	Vorinostat	2	Completed	1
DB00041	Aldesleukin	3	Completed	1
DB00023	Asparaginase Escherichia coli	3	Completed	1
DB01008	Busulfan	3	Completed	1
DB00531	Cyclophosphamide	3	Completed	1
DB00987	Cytarabine	3	Completed	1
DB00694	Daunorubicin	3	Completed	1
DB01234	Dexamethasone	3	Completed	1
DB00773	Etoposide	3	Completed	1
DB00099	Filgrastim	3	Completed	1
DB01073	Fludarabine	3	Completed	1
DB00741	Hydrocortisone	3	Completed	1
DB01177	Idarubicin	3	Completed	1
DB00563	Methotrexate	3	Completed	1
DB12146	Rigosertib	3	Completed	2
DB12146	Rigosertib	3	Terminated	1
DB00352	Tioguanine	3	Completed	1
DB00987	Cytarabine	Not Available	Completed	1
DB01177	Idarubicin	Not Available	Completed	1
DB00175	Pravastatin	Not Available	Completed	1