- Identifier
- DBSNPE006644
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
2988G>A | rs28371725 |
-1426C>T | Not Available |
-1235A>G | Not Available |
-1000G>A | Not Available |
100C>T | Not Available |
310G>T | Not Available |
746C>G | Not Available |
843T>G | Not Available |
1062A>G | Not Available |
1661G>C | Not Available |
2850C>T | Not Available |
3384A>C | Not Available |
3584G>A | Not Available |
3790C>T | Not Available |
4180G>C | Not Available |
4401C>T | Not Available |
4481G>A | Not Available |
- Allele Name
- CYP2D6*69
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred Effect
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
- References
- UltramĀ® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]