- Identifier
- DBSNPE006644
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
| 2988G>A | rs28371725 |
| -1426C>T | Not Available |
| -1235A>G | Not Available |
| -1000G>A | Not Available |
| 100C>T | Not Available |
| 310G>T | Not Available |
| 746C>G | Not Available |
| 843T>G | Not Available |
| 1062A>G | Not Available |
| 1661G>C | Not Available |
| 2850C>T | Not Available |
| 3384A>C | Not Available |
| 3584G>A | Not Available |
| 3790C>T | Not Available |
| 4180G>C | Not Available |
| 4401C>T | Not Available |
| 4481G>A | Not Available |
- Allele Name
- CYP2D6*69
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred Effect
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
- References
- Ultram® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]