Identifier DBSNPE006644 Drug Tramadol (DB00193) Interacting Gene/Enzyme Cytochrome P450 2D6 Gene Name CYP2D6 UniProt ID P10635 Defining Change(s) 2988G>A rs28371725 -1426C>T Not Available -1235A>G Not Available -1000G>A Not Available 100C>T Not Available 310G>T Not Available 746C>G Not Available 843T>G Not Available 1062A>G Not Available 1661G>C Not Available 2850C>T Not Available 3384A>C Not Available 3584G>A Not Available 3790C>T Not Available 4180G>C Not Available 4401C>T Not Available 4481G>A Not Available
Allele Name CYP2D6*69 Genotype(s) Not Available Type(s) ADR Inferred Effect Groups Non-functional CYP2D6 Description Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies. References Ultram® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link ]