Formyl-CoA:oxalate CoA-transferase

Details

Name
Formyl-CoA:oxalate CoA-transferase
Synonyms
  • 2.8.3.16
  • FCOCT
  • Formyl-coenzyme A transferase
Gene Name
frc
Organism
Oxalobacter formigenes
Amino acid sequence
>lcl|BSEQ0010916|Formyl-CoA:oxalate CoA-transferase
MTKPLDGINVLDFTHVQAGPACTQMMGFLGANVIKIERRGSGDMTRGWLQDKPNVDSLYF
TMFNCNKRSIELDMKTPEGKELLEQMIKKADVMVENFGPGALDRMGFTWEYIQELNPRVI
LASVKGYAEGHANEHLKVYENVAQCSGGAAATTGFWDGPPTVSGAALGDSNSGMHLMIGI
LAALEMRHKTGRGQKVAVAMQDAVLNLVRIKLRDQQRLERTGILAEYPQAQPNFAFDRDG
NPLSFDNITSVPRGGNAGGGGQPGWMLKCKGWETDADSYVYFTIAANMWPQICDMIDKPE
WKDDPAYNTFEGRVDKLMDIFSFIETKFADKDKFEVTEWAAQYGIPCGPVMSMKELAHDP
SLQKVGTVVEVVDEIRGNHLTVGAPFKFSGFQPEITRAPLLGEHTDEVLKELGLDDAKIK
ELHAKQVV
Number of residues
428
Molecular Weight
47326.775
Theoretical pI
5.1
GO Classification
Functions
formyl-CoA transferase activity
Processes
oxalate catabolic process
Components
cytoplasm
General Function
Formyl-coa transferase activity
Specific Function
Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Essential enzyme for the bacterium survival, as it relies on oxalic acid as its sole source of energy. Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. It can also use succinate as acceptor.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0002602|1287 bp
ATGACTAAACCATTAGATGGAATTAATGTGCTTGACTTTACCCACGTCCAGGCAGGTCCT
GCCTGTACACAGATGATGGGTTTCTTGGGCGCAAACGTCATCAAGATTGAAAGACGTGGT
TCCGGAGATATGACTCGTGGATGGCTGCAGGACAAACCAAATGTTGATTCCCTGTATTTC
ACGATGTTCAACTGTAACAAACGTTCGATTGAACTGGACATGAAAACCCCGGAAGGCAAA
GAGCTTCTGGAACAGATGATCAAGAAAGCCGACGTCATGGTCGAAAACTTCGGACCAGGC
GCACTGGACCGTATGGGCTTTACTTGGGAATACATTCAGGAACTGAATCCACGCGTCATT
CTGGCTTCCGTTAAAGGCTATGCAGAAGGCCACGCCAACGAACACCTGAAAGTTTATGAA
AACGTTGCACAGTGTTCCGGCGGTGCTGCAGCTACCACCGGTTTCTGGGATGGTCCTCCA
ACCGTTTCCGGCGCTGCTCTGGGTGACTCCAACTCCGGTATGCACCTGATGATCGGTATT
CTGGCCGCTCTGGAAATGCGTCACAAAACCGGCCGTGGTCAGAAAGTTGCCGTCGCTATG
CAGGACGCTGTTCTGAATCTGGTTCGTATCAAACTGCGTGACCAGCAACGTCTGGAAAGA
ACCGGCATTCTGGCTGAATACCCACAGGCTCAGCCTAACTTTGCCTTCGACAGAGACGGT
AACCCACTGTCCTTCGACAACATCACTTCCGTTCCACGTGGTGGTAACGCAGGTGGCGGC
GGCCAGCCAGGCTGGATGCTGAAATGTAAAGGTTGGGAAACCGATGCGGACTCCTACGTT
TACTTCACCATCGCTGCAAACATGTGGCCACAGATCTGCGACATGATCGACAAGCCAGAA
TGGAAAGACGACCCAGCCTACAACACATTCGAAGGTCGTGTTGACAAGCTGATGGACATC
TTCTCCTTCATCGAAACCAAGTTCGCTGACAAGGACAAATTCGAAGTTACCGAATGGGCT
GCCCAGTACGGCATTCCTTGCGGTCCGGTCATGTCCATGAAAGAACTGGCTCACGATCCT
TCCCTGCAGAAAGTTGGTACCGTCGTTGAAGTTGTCGACGAAATTCGTGGTAACCACCTG
ACCGTTGGCGCACCGTTCAAATTCTCCGGATTCCAGCCGGAAATTACCCGTGCTCCGCTG
TTGGGCGAACATACCGACGAAGTTCTGAAAGAACTGGGTCTTGACGATGCCAAGATCAAG
GAACTGCATGCAAAACAGGTAGTTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO06644
UniProtKB Entry NameFCTA_OXAFO
GenBank Protein ID2102704
GenBank Gene IDU82167
General References
  1. Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB: DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes. J Bacteriol. 1997 May;179(10):3378-81. [Article]
  2. Baetz AL, Allison MJ: Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes. J Bacteriol. 1990 Jul;172(7):3537-40. [Article]
  3. Ricagno S, Jonsson S, Richards N, Lindqvist Y: Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. EMBO J. 2003 Jul 1;22(13):3210-9. [Article]
  4. Jonsson S, Ricagno S, Lindqvist Y, Richards NG: Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. J Biol Chem. 2004 Aug 20;279(34):36003-12. Epub 2004 Jun 21. [Article]
  5. Toyota CG, Berthold CL, Gruez A, Jonsson S, Lindqvist Y, Cambillau C, Richards NG: Differential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferase. J Bacteriol. 2008 Apr;190(7):2556-64. doi: 10.1128/JB.01823-07. Epub 2008 Feb 1. [Article]
  6. Berthold CL, Toyota CG, Richards NG, Lindqvist Y: Reinvestigation of the catalytic mechanism of formyl-CoA transferase, a class III CoA-transferase. J Biol Chem. 2008 Mar 7;283(10):6519-29. Epub 2007 Dec 27. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01846Oxidized coenzyme AexperimentalunknownDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails