Growth/differentiation factor 8
Details
- Name
- Growth/differentiation factor 8
- Synonyms
- GDF-8
- GDF8
- Myostatin
- Gene Name
- MSTN
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017101|Growth/differentiation factor 8 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII YGKIPAMVVDRCGCS
- Number of residues
- 375
- Molecular Weight
- 42749.8
- Theoretical pI
- 6.74
- GO Classification
- Functionscytokine activity / growth factor activity / heparin binding / identical protein binding / receptor binding / transforming growth factor beta receptor bindingProcessescell development / cellular response to dexamethasone stimulus / mitophagy in response to mitochondrial depolarization / muscle cell cellular homeostasis / muscle organ development / negative regulation of insulin receptor signaling pathway / negative regulation of kinase activity / negative regulation of muscle hypertrophy / negative regulation of myoblast differentiation / negative regulation of myoblast proliferation / negative regulation of protein kinase B signaling / negative regulation of satellite cell differentiation / negative regulation of skeletal muscle satellite cell proliferation / negative regulation of skeletal muscle tissue growth / ovulation cycle process / positive regulation of defense response to virus by host / positive regulation of pathway-restricted SMAD protein phosphorylation / positive regulation of transcription, DNA-templated / regulation of apoptotic process / regulation of MAPK cascade / response to electrical stimulus / response to estrogen / response to ethanol / response to gravity / response to heat / response to muscle activity / response to testosterone / skeletal muscle atrophy / skeletal muscle tissue regeneration / SMAD protein signal transduction / transforming growth factor beta receptor signaling pathway / xenophagyComponentscytoplasm / extracellular space
- General Function
- Transforming growth factor beta receptor binding
- Specific Function
- Acts specifically as a negative regulator of skeletal muscle growth.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017102|Growth/differentiation factor 8 (MSTN) ATGCAAAAACTGCAACTCTGTGTTTATATTTACCTGTTTATGCTGATTGTTGCTGGTCCA GTGGATCTAAATGAGAACAGTGAGCAAAAAGAAAATGTGGAAAAAGAGGGGCTGTGTAAT GCATGTACTTGGAGACAAAACACTAAATCTTCAAGAATAGAAGCCATTAAGATACAAATC CTCAGTAAACTTCGTCTGGAAACAGCTCCTAACATCAGCAAAGATGTTATAAGACAACTT TTACCCAAAGCTCCTCCACTCCGGGAACTGATTGATCAGTATGATGTCCAGAGGGATGAC AGCAGCGATGGCTCTTTGGAAGATGACGATTATCACGCTACAACGGAAACAATCATTACC ATGCCTACAGAGTCTGATTTTCTAATGCAAGTGGATGGAAAACCCAAATGTTGCTTCTTT AAATTTAGCTCTAAAATACAATACAATAAAGTAGTAAAGGCCCAACTATGGATATATTTG AGACCCGTCGAGACTCCTACAACAGTGTTTGTGCAAATCCTGAGACTCATCAAACCTATG AAAGACGGTACAAGGTATACTGGAATCCGATCTCTGAAACTTGACATGAACCCAGGCACT GGTATTTGGCAGAGCATTGATGTGAAGACAGTGTTGCAAAATTGGCTCAAACAACCTGAA TCCAACTTAGGCATTGAAATAAAAGCTTTAGATGAGAATGGTCATGATCTTGCTGTAACC TTCCCAGGACCAGGAGAAGATGGGCTGAATCCGTTTTTAGAGGTCAAGGTAACAGACACA CCAAAAAGATCCAGAAGGGATTTTGGTCTTGACTGTGATGAGCACTCAACAGAATCACGA TGCTGTCGTTACCCTCTAACTGTGGATTTTGAAGCTTTTGGATGGGATTGGATTATCGCT CCTAAAAGATATAAGGCCAATTACTGCTCTGGAGAGTGTGAATTTGTATTTTTACAAAAA TATCCTCATACTCATCTGGTACACCAAGCAAACCCCAGAGGTTCAGCAGGCCCTTGCTGT ACTCCCACAAAGATGTCTCCAATTAATATGCTATATTTTAATGGCAAAGAACAAATAATA TATGGGAAAATTCCAGCGATGGTAGTAGACCGCTGTGGGTGCTCATGA
- Chromosome Location
- 2
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O14793 UniProtKB Entry Name GDF8_HUMAN GenBank Gene ID AF019627 GenAtlas ID MSTN HGNC ID HGNC:4223 - General References
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