Peptide deformylase 2

Details

Name
Peptide deformylase 2
Synonyms
  • 3.5.1.88
  • PDF 2
  • Polypeptide deformylase 2
Gene Name
Not Available
Organism
Geobacillus stearothermophilus
Amino acid sequence
>lcl|BSEQ0016506|Peptide deformylase 2
MITMKDIIKEGHPTLRKVAEPVPLPPSEEDKRILQSLLDYVKMSQDPELAAKYGLRPGIG
LAAPQINVSKRMIAVHVTDENGTLYSYALFNPKIVSHSVQQCYLTTGEGCLSVDRDVPGY
VLRYARITVTGTTLDGEEVTLRLKGLPAIVFQHEIDHLNGIMFYDRINPADPFQVPDGAI
PIGR
Number of residues
184
Molecular Weight
20382.365
Theoretical pI
6.35
GO Classification
Functions
iron ion binding / peptide deformylase activity
Processes
translation
General Function
Peptide deformylase activity
Specific Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0003262|555 bp
ATGATCACCATGAAAGATATCATTAAAGAAGGGCATCCGACGCTGCGGAAAGTGGCTGAG
CCCGTTCCGCTGCCGCCTTCAGAGGAAGACAAACGCATTTTGCAAAGCTTGCTTGACTAT
GTGAAAATGAGCCAAGATCCGGAACTGGCGGCCAAATACGGCCTGCGGCCNGGCATCGGC
CTCGCCGCTCCGCAAATCAACGTCTCCAAACGGATGATTGCCGTTCATGTCACTGATGAA
AACGGAACGCTGTACAGCTATGCCTTGTTCAATCCGAAAATCGTCAGCCACTCTGTGCAG
CAATGTTATTTGACGACGGGGGAAGGCTGCCTGTCGGTCGACCGTGATGTGCCCGGATAC
GTACTGCGCTATGCCCGCATCACGGTCACCGGCACGACGCTCGACGGCGAGGAAGTCACC
TTGCGCCTCAAAGGATTGCCGGCCATCGTCTTCCAGCATGAAATCGACCATTTAAACGGC
ATTATGTTTTATGACCGCATCAATCCGGCCGACCCGTTCCAAGTGCCAGACGGGGCGATC
CCGATCGGGCGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO31410
UniProtKB Entry NameDEF2_GEOSE
GenBank Protein ID2266414
GenBank Gene IDY10549
General References
  1. Meinnel T, Lazennec C, Villoing S, Blanquet S: Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion. J Mol Biol. 1997 Apr 4;267(3):749-61. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB043102-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-AmideexperimentalunknownDetails