Neuropilin-2
Details
- Name
- Neuropilin-2
- Synonyms
- Vascular endothelial cell growth factor 165 receptor 2
- VEGF165R2
- Gene Name
- NRP2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052526|Neuropilin-2 MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR SGEIAIDDIRISTDVPLENCMEPISAFAGENFKVDIPEIHEREGYEDEIDDEYEVDWSNS SSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSR SCTTLENYNFELYDGLKHKVKMNHQKCCSEA
- Number of residues
- 931
- Molecular Weight
- 104829.73
- Theoretical pI
- Not Available
- GO Classification
- Functionscytokine binding / growth factor binding / heparin binding / identical protein binding / metal ion binding / semaphorin receptor activity / signaling receptor activity / vascular endothelial growth factor-activated receptor activityProcessesangiogenesis / axon extension involved in axon guidance / axon guidance / cell adhesion / cellular response to leukemia inhibitory factor / dorsal root ganglion morphogenesis / facial nerve structural organization / facioacoustic ganglion development / gonadotrophin-releasing hormone neuronal migration to the hypothalamus / negative chemotaxis / nerve development / neural crest cell migration involved in autonomic nervous system development / outflow tract septum morphogenesis / positive regulation of endothelial cell migration / positive regulation of endothelial cell proliferation / regulation of postsynapse organization / semaphorin-plexin signaling pathway involved in neuron projection guidance / sensory neuron axon guidance / sympathetic ganglion development / sympathetic neuron projection extension / sympathetic neuron projection guidance / trigeminal ganglion development / vascular endothelial growth factor receptor signaling pathway / ventral trunk neural crest cell migration / vestibulocochlear nerve structural organization / viral processComponentsaxon / extracellular region / glutamatergic synapse / integral component of membrane / membrane / plasma membrane / semaphorin receptor complex
- General Function
- High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
- Specific Function
- Cytokine binding
- Pfam Domain Function
- Transmembrane Regions
- 865-889
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052527|Neuropilin-2 (NRP2) ATGGATATGTTTCCTCTCACCTGGGTTTTCTTAGCCCTCTACTTTTCAAGACACCAAGTG AGAGGCCAACCAGACCCACCGTGCGGAGGTCGTTTGAATTCCAAAGATGCTGGCTATATC ACCTCTCCCGGTTACCCCCAGGACTACCCCTCCCACCAGAACTGCGAGTGGATTGTTTAC GCCCCCGAACCCAACCAGAAGATTGTCCTCAACTTCAACCCTCACTTTGAAATCGAGAAG CACGACTGCAAGTATGACTTTATCGAGATTCGGGATGGGGACAGTGAATCCGCAGACCTC CTGGGCAAACACTGTGGGAACATCGCCCCGCCCACCATCATCTCCTCGGGCTCCATGCTC TACATCAAGTTCACCTCCGACTACGCCCGGCAGGGGGCAGGCTTCTCTCTGCGCTACGAG ATCTTCAAGACAGGCTCTGAAGATTGCTCAAAAAACTTCACAAGCCCCAACGGGACCATC GAATCTCCTGGGTTTCCTGAGAAGTATCCACACAACTTGGACTGCACCTTTACCATCCTG GCCAAACCCAAGATGGAGATCATCCTGCAGTTCCTGATCTTTGACCTGGAGCATGACCCT TTGCAGGTGGGAGAGGGGGACTGCAAGTACGATTGGCTGGACATCTGGGATGGCATTCCA CATGTTGGCCCCCTGATTGGCAAGTACTGTGGGACCAAAACACCCTCTGAACTTCGTTCA TCGACGGGGATCCTCTCCCTGACCTTTCACACGGACATGGCGGTGGCCAAGGATGGCTTC TCTGCGCGTTACTACCTGGTCCACCAAGAGCCACTAGAGAACTTTCAGTGCAATGTTCCT CTGGGCATGGAGTCTGGCCGGATTGCTAATGAACAGATCAGTGCCTCATCTACCTACTCT GATGGGAGGTGGACCCCTCAACAAAGCCGGCTCCATGGTGATGACAATGGCTGGACCCCC AACTTGGATTCCAACAAGGAGTATCTCCAGGTGGACCTGCGCTTTTTAACCATGCTCACG GCCATCGCAACACAGGGAGCGATTTCCAGGGAAACACAGAATGGCTACTATGTCAAATCC TACAAGCTGGAAGTCAGCACTAATGGAGAGGACTGGATGGTGTACCGGCATGGCAAAAAC CACAAGGTATTTCAAGCCAACAACGATGCAACTGAGGTGGTTCTGAACAAGCTCCACGCT CCACTGCTGACAAGGTTTGTTAGAATCCGCCCTCAGACCTGGCACTCAGGTATCGCCCTC CGGCTGGAGCTCTTCGGCTGCCGGGTCACAGATGCTCCCTGCTCCAACATGCTGGGGATG CTCTCAGGCCTCATTGCAGACTCCCAGATCTCCGCCTCTTCCACCCAGGAATACCTCTGG AGCCCCAGTGCAGCCCGCCTGGTTAGCAGCCGCTCGGGCTGGTTCCCTCGAATCCCTCAG GCCCAGCCCGGTGAGGAGTGGCTTCAGGTAGATCTGGGAACACCCAAGACAGTGAAAGGT GTCATCATCCAGGGAGCCCGCGGAGGAGACAGTATCACTGCTGTGGAAGCCAGAGCATTT GTGCGCAAGTTCAAAGTCTCCTACAGCCTAAACGGCAAGGACTGGGAATACATTCAGGAC CCCAGGACCCAGCAGCCAAAGCTGTTCGAAGGGAACATGCACTATGACACCCCTGACATC CGAAGGTTTGACCCCATTCCGGCACAGTATGTGCGGGTATACCCGGAGAGGTGGTCGCCG GCGGGGATTGGGATGCGGCTGGAGGTGCTGGGCTGTGACTGGACAGACTCCAAGCCCACG GTAGAGACGCTGGGACCCACTGTGAAGAGCGAAGAGACAACCACCCCCTACCCCACCGAA GAGGAGGCCACAGAGTGTGGGGAGAACTGCAGCTTTGAGGATGACAAAGATTTGCAGCTC CCTTCGGGATTCAATTGCAACTTCGATTTCCTCGAGGAGCCCTGTGGTTGGATGTATGAC CATGCCAAGTGGCTCCGGACCACCTGGGCCAGCAGCTCCAGCCCAAACGACCGGACGTTT CCAGATGACAGGAATTTCTTGCGGCTGCAGAGTGACAGCCAGAGAGAGGGCCAGTATGCC CGGCTCATCAGCCCCCCTGTCCACCTGCCCCGAAGCCCGGTGTGCATGGAGTTCCAGTAC CAGGCCACGGGCGGCCGCGGGGTGGCGCTGCAGGTGGTGCGGGAAGCCAGCCAGGAGAGC AAGTTGCTGTGGGTCATCCGTGAGGACCAGGGCGGCGAGTGGAAGCACGGGCGGATCATC CTGCCCAGCTACGACATGGAGTACCAGATTGTGTTCGAGGGAGTGATAGGGAAAGGACGT TCCGGAGAGATTGCCATTGATGACATTCGGATAAGCACTGATGTCCCACTGGAGAACTGC ATGGAACCCATCTCGGCTTTTGCAGGTGAGAATTTTAAAGTGGACATCCCAGAAATACAT GAGAGAGAAGGATATGAAGATGAAATTGATGATGAATACGAGGTGGACTGGAGCAATTCT TCTTCTGCAACCTCAGGGTCTGGCGCCCCCTCGACCGACAAAGAAAAGAGCTGGCTGTAC ACCCTGGATCCCATCCTCATCACCATCATCGCCATGAGCTCACTGGGCGTCCTCCTGGGG GCCACCTGTGCAGGCCTCCTGCTCTACTGCACCTGTTCCTACTCGGGCCTGAGCTCCCGA AGCTGCACCACACTGGAGAACTACAACTTCGAGCTCTACGATGGCCTTAAGCACAAGGTC AAGATGAACCACCAAAAGTGCTGCTCCGAGGCATGA
- Chromosome Location
- 2
- Locus
- 2q33.3
- External Identifiers
Resource Link UniProtKB ID O60462 UniProtKB Entry Name NRP2_HUMAN HGNC ID HGNC:8005 - General References
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