Interferon alpha-2

Details

Name
Interferon alpha-2
Synonyms
  • IFN-alpha-2
  • IFNA2A
  • IFNA2B
  • IFNA2C
  • Interferon alpha-A
  • LeIF A
Gene Name
IFNA2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019425|Interferon alpha-2
MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRKISLFSCLKDRHDFG
FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA
CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL
QESLRSKE
Number of residues
188
Molecular Weight
21549.765
Theoretical pI
6.75
GO Classification
Functions
cytokine activity / type I interferon receptor binding
Processes
adaptive immune response / apoptotic process / B cell differentiation / B cell proliferation / blood coagulation / cell surface receptor signaling pathway / cell-cell signaling / cytokine-mediated signaling pathway / defense response to virus / humoral immune response / inflammatory response / innate immune response / natural killer cell activation involved in immune response / negative regulation of gene expression / negative regulation of interleukin-13 secretion / negative regulation of interleukin-5 secretion / negative regulation of T cell differentiation / negative regulation of T-helper 2 cell cytokine production / negative regulation of transcription, DNA-templated / negative regulation of viral entry into host cell / positive regulation of peptidyl-serine phosphorylation of STAT protein / positive regulation of phosphorylation / positive regulation of transcription, DNA-templated / positive regulation of tyrosine phosphorylation of Stat3 protein / regulation of type I interferon-mediated signaling pathway / response to exogenous dsRNA / T cell activation involved in immune response / type I interferon signaling pathway
Components
extracellular region / extracellular space
General Function
Type i interferon receptor binding
Specific Function
Produced by macrophages, IFN-alpha have antiviral activities.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0019426|Interferon alpha-2 (IFNA2)
ATGGCCTTGACCTTTGCTTTACTGGTGGCCCTCCTGGTGCTCAGCTGCAAGTCAAGCTGC
TCTGTGGGCTGTGATCTGCCTCAAACCCACAGCCTGGGTAGCAGGAGGACCTTGATGCTC
CTGGCACAGATGAGGAGAATCTCTCTTTTCTCCTGCTTGAAGGACAGACATGACTTTGGA
TTTCCCCAGGAGGAGTTTGGCAACCAGTTCCAAAAGGCTGAAACCATCCCTGTCCTCCAT
GAGATGATCCAGCAGATCTTCAATCTCTTCAGCACAAAGGACTCATCTGCTGCTTGGGAT
GAGACCCTCCTAGACAAATTCTACACTGAACTCTACCAGCAGCTGAATGACCTGGAAGCC
TGTGTGATACAGGGGGTGGGGGTGACAGAGACTCCCCTGATGAAGGAGGACTCCATTCTG
GCTGTGAGGAAATACTTCCAAAGAATCACTCTCTATCTGAAAGAGAAGAAATACAGCCCT
TGTGCCTGGGAGGTTGTCAGAGCAGAAATCATGAGATCTTTTTCTTTGTCAACAAACTTG
CAAGAAAGTTTAAGAAGTAAGGAATGA
Chromosome Location
9
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP01563
UniProtKB Entry NameIFNA2_HUMAN
GenBank Gene IDM29883
GenAtlas IDIFNA2
HGNC IDHGNC:5423
General References
  1. Goeddel DV, Yelverton E, Ullrich A, Heyneker HL, Miozzari G, Holmes W, Seeburg PH, Dull T, May L, Stebbing N, Crea R, Maeda S, McCandliss R, Sloma A, Tabor JM, Gross M, Familletti PC, Pestka S: Human leukocyte interferon produced by E. coli is biologically active. Nature. 1980 Oct 2;287(5781):411-6. [Article]
  2. Goeddel DV, Leung DW, Dull TJ, Gross M, Lawn RM, McCandliss R, Seeburg PH, Ullrich A, Yelverton E, Gray PW: The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature. 1981 Mar 5;290(5801):20-6. [Article]
  3. Lawn RM, Gross M, Houck CM, Franke AE, Gray PV, Goeddel DV: DNA sequence of a major human leukocyte interferon gene. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5435-9. [Article]
  4. Oliver G, Balbas P, Valle F, Soberon X, Bolivar F: [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli]. Rev Latinoam Microbiol. 1985 Apr-Jun;27(2):141-50. [Article]
  5. Austruy E, Bagnis C, Carbuccia N, Maroc C, Birg F, Dubreuil P, Mannoni P, Chabannon C: A defective retroviral vector encoding human interferon-alpha2 can transduce human leukemic cell lines. Cancer Gene Ther. 1998 Jul-Aug;5(4):247-56. [Article]
  6. Gull I, Samra ZQ, Aslam MS, Athar MA: Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b. Springerplus. 2013 Jun 15;2(1):264. doi: 10.1186/2193-1801-2-264. Print 2013 Dec. [Article]
  7. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  8. Streuli M, Nagata S, Weissmann C: At least three human type alpha interferons: structure of alpha 2. Science. 1980 Sep 19;209(4463):1343-7. [Article]
  9. Weber H, Weissmann C: Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli. Nucleic Acids Res. 1983 Aug 25;11(16):5661-9. [Article]
  10. Allen G, Fantes KH: A family of structural genes for human lymphoblastoid (leukocyte-type) interferon. Nature. 1980 Oct 2;287(5781):408-11. [Article]
  11. Nyman TA, Tolo H, Parkkinen J, Kalkkinen N: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. Biochem J. 1998 Jan 15;329 ( Pt 2):295-302. [Article]
  12. Wetzel R: Assignment of the disulphide bonds of leukocyte interferon. Nature. 1981 Feb 12;289(5798):606-7. [Article]
  13. Adolf GR, Kalsner I, Ahorn H, Maurer-Fogy I, Cantell K: Natural human interferon-alpha 2 is O-glycosylated. Biochem J. 1991 Jun 1;276 ( Pt 2):511-8. [Article]
  14. Lee N, Ni D, Brissette R, Chou M, Hussain M, Gill DS, Liao MJ, Testa D: Interferon-alpha 2 variants in the human genome. J Interferon Cytokine Res. 1995 Apr;15(4):341-9. [Article]
  15. Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP: A homology model of human interferon alpha-2. Proteins. 1993 Sep;17(1):62-74. [Article]
  16. Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, Walter MR: Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. Structure. 1996 Dec 15;4(12):1453-63. [Article]
  17. Klaus W, Gsell B, Labhardt AM, Wipf B, Senn H: The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. J Mol Biol. 1997 Dec 12;274(4):661-75. [Article]
  18. Quadt-Akabayov SR, Chill JH, Levy R, Kessler N, Anglister J: Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex. Protein Sci. 2006 Nov;15(11):2656-68. Epub 2006 Sep 25. [Article]
  19. Nudelman I, Akabayov SR, Schnur E, Biron Z, Levy R, Xu Y, Yang D, Anglister J: Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY. Biochemistry. 2010 Jun 29;49(25):5117-33. doi: 10.1021/bi100041f. [Article]
  20. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12773SifalimumabinvestigationalunknownDetails