Ig kappa chain C region

Details

Name
Ig kappa chain C region
Synonyms
Not Available
Gene Name
IGKC
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012677|Ig kappa chain C region
TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDS
KDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Number of residues
106
Molecular Weight
11608.765
Theoretical pI
5.68
GO Classification
Functions
antigen binding / immunoglobulin receptor binding
Processes
B cell receptor signaling pathway / complement activation / complement activation, classical pathway / defense response to bacterium / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / immune response / innate immune response / phagocytosis, engulfment / phagocytosis, recognition / positive regulation of B cell activation / receptor-mediated endocytosis / regulation of immune response / retina homeostasis
Components
blood microparticle / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / immunoglobulin complex, circulating / plasma membrane
General Function
Immunoglobulin receptor binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
2p12
External Identifiers
ResourceLink
UniProtKB IDP01834
UniProtKB Entry NameIGKC_HUMAN
GenBank Protein ID185945
GenBank Gene IDJ00241
HGNC IDHGNC:5716
General References
  1. Gottlieb PD, Cunningham BA, Rutishauser U, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain. Biochemistry. 1970 Aug 4;9(16):3155-61. [Article]
  2. Gall WE, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. Biochemistry. 1970 Aug 4;9(16):3188-96. [Article]
  3. Suter L, Barnikol HU, Watanabe S, Hilschmann N: [Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production]. Hoppe Seylers Z Physiol Chem. 1972 Feb;353(2):189-208. [Article]
  4. Hieter PA, Max EE, Seidman JG, Maizel JV Jr, Leder P: Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell. 1980 Nov;22(1 Pt 1):197-207. [Article]
  5. Hilschmann N: [The complete amino acid sequence of Bence Jones protein Cum (kappa-type)]. Hoppe Seylers Z Physiol Chem. 1967 Dec;348(12):1718-22. [Article]
  6. Titani K, Shinoda T, Putnam FW: The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges. J Biol Chem. 1969 Jul 10;244(13):3550-60. [Article]
  7. Kohler H, Shimizu A, Paul C, Putnam FW: Macroglobulin structure: variable sequence of light and heavy chains. Science. 1970 Jul 3;169(3940):56-9. [Article]
  8. Olsen KE, Sletten K, Westermark P: Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain. Biochem Biophys Res Commun. 1998 Apr 28;245(3):713-6. [Article]
  9. Azkargorta M, Soria J, Ojeda C, Guzman F, Acera A, Iloro I, Suarez T, Elortza F: Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification. J Proteome Res. 2015 Jun 5;14(6):2649-58. doi: 10.1021/acs.jproteome.5b00179. Epub 2015 May 20. [Article]
  10. Stavnezer-Nordgren J, Kekish O, Zegers BJ: Molecular defects in a human immunoglobulin kappa chain deficiency. Science. 1985 Oct 25;230(4724):458-61. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07375EtiocholanedioneexperimentalunknownDetails
DB07416(2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATEexperimentalunknownDetails
DB074413-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACIDexperimentalunknownDetails
DB04688MethylecgonineexperimentalunknownDetails
DB07716(4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOLexperimentalunknownDetails
DB07784[4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACIDexperimentalunknownDetails
DB078824-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACIDexperimentalunknownDetails
DB07893PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATEexperimentalunknownDetails
DB07909(1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOLexperimentalunknownDetails
DB08289N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDEexperimentalunknownDetails
DB08413METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTERexperimentalunknownDetails
DB085624-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACIDexperimentalunknownDetails
DB01851Tetrabutylammonium IonexperimentalunknownDetails
DB08647TrazeolideexperimentalunknownDetails