Alpha-2-HS-glycoprotein
Details
- Name
- Alpha-2-HS-glycoprotein
- Synonyms
- Alpha-2-Z-globulin
- Ba-alpha-2-glycoprotein
- FETUA
- Fetuin-A
- Gene Name
- AHSG
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049809|Alpha-2-HS-glycoprotein MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTL NQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLK LDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNF QLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGG AEVAVTCTVFQTQPVTSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVL LAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPG RIRHFKV
- Number of residues
- 367
- Molecular Weight
- 39324.35
- Theoretical pI
- Not Available
- GO Classification
- Functionscysteine-type endopeptidase inhibitor activity / endopeptidase inhibitor activity / kinase inhibitor activityProcessesacute-phase response / negative regulation of biomineral tissue development / negative regulation of bone mineralization / negative regulation of insulin receptor signaling pathway / neutrophil degranulation / ossification / pinocytosis / platelet degranulation / positive regulation of phagocytosis / regulation of bone mineralization / regulation of inflammatory response / skeletal system developmentComponentsblood microparticle / extracellular exosome / extracellular matrix / extracellular region / extracellular space / Golgi apparatus / platelet alpha granule lumen / secretory granule lumen
- General Function
- Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
- Specific Function
- Cysteine-type endopeptidase inhibitor activity
- Pfam Domain Function
- Cystatin (PF00031)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049810|Alpha-2-HS-glycoprotein (AHSG) ATGAAGTCCCTCGTCCTGCTCCTTTGTCTTGCTCAGCTCTGGGGCTGCCACTCAGCCCCA CATGGCCCAGGGCTGATTTATAGACAACCGAACTGCGATGATCCAGAAACTGAGGAAGCA GCTCTGGTGGCTATAGACTACATCAATCAAAACCTTCCTTGGGGATACAAACACACCTTG AACCAGATTGATGAAGTAAAGGTGTGGCCTCAGCAGCCCTCCGGAGAGCTGTTTGAGATT GAAATAGACACCCTGGAAACCACCTGCCATGTGCTGGACCCCACCCCTGTGGCAAGATGC AGCGTGAGGCAGCTGAAGGAGCATGCTGTCGAAGGAGACTGTGATTTCCAGCTGTTGAAA CTAGATGGCAAGTTTTCCGTGGTATACGCAAAATGTGATTCCAGTCCAGACTCAGCCGAG GACGTGCGCAAGGTGTGCCAAGACTGCCCCCTGCTGGCCCCGCTGAACGACACCAGGGTG GTGCACGCCGCGAAAGCTGCCCTGGCCGCCTTCAACGCTCAGAACAACGGCTCCAATTTT CAGCTGGAGGAAATTTCCCGGGCTCAGCTTGTGCCCCTCCCACCTTCTACCTATGTGGAG TTTACAGTGTCTGGCACTGACTGTGTTGCTAAAGAGGCCACAGAGGCAGCCAAGTGTAAC CTGCTGGCAGAAAAGCAATATGGCTTTTGTAAGGCAACACTCAGTGAGAAGCTTGGTGGG GCAGAGGTTGCAGTGACCTGCATGGTGTTCCAAACACAGCCCGTGAGCTCACAGCCCCAA CCAGAAGGTGCCAATGAAGCAGTCCCCACACCCGTGGTGGACCCAGATGCACCTCCGTCC CCTCCACTTGGCGCACCTGGACTCCCTCCAGCTGGCTCACCCCCAGACTCCCATGTGTTA CTGGCAGCTCCTCCAGGACACCAGTTGCACCGGGCGCACTACGACCTGCGCCACACCTTC ATGGGTGTGGTCTCATTGGGGTCACCCTCAGGAGAAGTGTCGCACCCCCGGAAAACACGC ACAGTGGTGCAGCCTAGTGTTGGTGCTGCTGCTGGGCCAGTGGTTCCTCCATGTCCGGGG AGGATCAGACACTTCAAGGTCTAG
- Chromosome Location
- 3
- Locus
- 3q27.3
- External Identifiers
Resource Link UniProtKB ID P02765 UniProtKB Entry Name FETUA_HUMAN HGNC ID HGNC:349 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09130 Copper approved, investigational unknown Details DB01593 Zinc approved, investigational unknown Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown chelator Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown chelator Details