Hemagglutinin

Details

Name
Hemagglutinin
Synonyms
  • Hemagglutinin precursor
Gene Name
HA
Organism
Influenza A virus (strain A/Aichi/2/1968 H3N2)
Amino acid sequence
>lcl|BSEQ0012013|Hemagglutinin
MKTIIALSYIFCLALGQDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQ
SSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPD
YASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVL
NVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVR
GLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITP
NGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWE
GMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEG
RIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGN
GCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISC
FLLCVVLLGFIMWACQRGNIRCNICI
Number of residues
566
Molecular Weight
63415.315
Theoretical pI
6.71
GO Classification
Processes
clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / fusion of virus membrane with host plasma membrane / virion attachment to host cell
Components
host cell plasma membrane / integral component of membrane / viral envelope / virion membrane
General Function
Not Available
Specific Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Pfam Domain Function
Transmembrane Regions
531-551
Cellular Location
Virion membrane
Gene sequence
>lcl|BSEQ0005614|1701 bp
ATGAAGACCATCATTGCTTTGAGCTACATTTTCTGTCTGGCTCTCGGCCAAGACCTTCCA
GGAAATGACAACAGCACAGCAACGCTGTGCCTGGGACATCATGCGGTGCCAAACGGAACA
CTAGTGAAAACAATCACAGATGATCAGATTGAAGTGACTAATGCTACTGAGCTAGTTCAG
AGCTCCTCAACGGGGAAAATATGCAACAATCCTCATCGAATCCTTGATGGAATAGACTGC
ACACTGATAGATGCTCTATTGGGGGACCCTCATTGTGATGTTTTTCAAAATGAGACATGG
GACCTTTTCGTTGAACGCAGCAAAGCTTTCAGCAACTGTTACCCTTATGATGTGCCAGAT
TATGCCTCCCTTAGGTCACTAGTTGCCTCGTCAGGCACTCTGGAGTTTATCACTGAGGGT
TTCACTTGGACTGGGGTCACTCAGAATGGGGGAAGCAATGCTTGCAAAAGGGGACCTGGT
AGCGGTTTTTTCAGTAGACTGAACTGGTTGACCAAATCAGGAAGCACATATCCAGTGCTG
AACGTGACTATGCCAAACAATGACAATTTTGACAAACTATACATTTGGGGGATTCACCAC
CCGAGCACGAACCAAGAACAAACCAGCCTGTATGTTCAAGCATCAGGGAGAGTCACAGTC
TCTACCAGGAGAAGCCAGCAAACTATAATCCCGAATATCGGGTCCAGACCCTGGGTAAGG
GGTCTGTCTAGTAGAATAAGCATCTATTGGACAATAGTTAAGCCGGGAGACGTACTGGTA
ATTAATAGTAATGGGAACCTAATCGCTCCTCGGGGTTATTTCAAAATGCGCACTGGGAAA
AGCTCAATAATGAGGTCAGATGCACCTATTGATACCTGTATTTCTGAATGCATCACTCCA
AATGGAAGCATTCCCAATGACAAGCCCTTTCAAAACGTAAACAAGATCACATATGGAGCA
TGCCCCAAGTATGTTAAGCAAAACACCCTGAAGTTGGCAACAGGGATGCGGAATGTACCA
GAGAAACAAACTAGAGGCCTATTCGGCGCAATAGCAGGTTTCATAGAAAATGGTTGGGAG
GGAATGATAGACGGTTGGTACGGTTTCAGGCATCAAAATTCTGAGGGCACAGGACAAGCA
GCAGATCTTAAAAGCACTCAAGCAGCCATCGACCAAATCAATGGGAAATTGAACAGGGTA
ATCGAGAAGACGAACGAGAAATTCCATCAAATCGAAAAGGAATTCTCAGAAGTAGAAGGG
AGAATTCAGGACCTCGAGAAATACGTTGAAGACACTAAAATAGATCTCTGGTCTTACAAT
GCGGAGCTTCTTGTCGCTCTGGAGAATCAACATACAATTGACCTGACTGACTCGGAAATG
AACAAGCTGTTTGAAAAAACAAGGAGGCAACTGAGGGAAAATGCTGAAGAGATGGGCAAT
GGTTGCTTCAAAATATACCACAAATGTGACAACGCTTGCATAGAGTCAATCAGAAATGGT
ACTTATGACCATGATGTATACAGAGACGAAGCATTAAACAACCGGTTTCAGATCAAAGGT
GTTGAACTGAAGTCTGGATACAAAGACTGGATCCTGTGGATTTCCTTTGCCATATCATGC
TTTTTGCTTTGTGTTGTTTTGCTGGGGTTCATCATGTGGGCCTGCCAGAGAGGCAACATT
AGGTGCAACATTTGCATTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP03437
UniProtKB Entry NameHEMA_I68A0
GenBank Gene IDJ02090
General References
  1. Verhoeyen M, Fang R, Jou WM, Devos R, Huylebroeck D, Saman E, Fiers W: Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75. Nature. 1980 Aug 21;286(5775):771-6. [Article]
  2. Abe Y, Takashita E, Sugawara K, Matsuzaki Y, Muraki Y, Hongo S: Effect of the addition of oligosaccharides on the biological activities and antigenicity of influenza A/H3N2 virus hemagglutinin. J Virol. 2004 Sep;78(18):9605-11. [Article]
  3. Beppu Y, Imamura Y, Tashiro M, Towatari T, Ariga H, Kido H: Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses. J Biochem. 1997 Feb;121(2):309-16. [Article]
  4. Wilson IA, Skehel JJ, Wiley DC: Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature. 1981 Jan 29;289(5796):366-73. [Article]
  5. Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC: Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature. 1988 Jun 2;333(6172):426-31. [Article]
  6. Weis WI, Cusack SC, Brown JH, Daniels RS, Skehel JJ, Wiley DC: The structure of a membrane fusion mutant of the influenza virus haemagglutinin. EMBO J. 1990 Jan;9(1):17-24. [Article]
  7. Weis WI, Brunger AT, Skehel JJ, Wiley DC: Refinement of the influenza virus hemagglutinin by simulated annealing. J Mol Biol. 1990 Apr 20;212(4):737-61. [Article]
  8. Bullough PA, Hughson FM, Skehel JJ, Wiley DC: Structure of influenza haemagglutinin at the pH of membrane fusion. Nature. 1994 Sep 1;371(6492):37-43. [Article]
  9. Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T: Antigen distortion allows influenza virus to escape neutralization. Nat Struct Biol. 1998 Feb;5(2):119-23. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07726t-ButylhydroquinoneexperimentalunknownDetails