Granulocyte-macrophage colony-stimulating factor
Details
- Name
- Granulocyte-macrophage colony-stimulating factor
- Synonyms
- Colony-stimulating factor
- CSF
- GM-CSF
- GMCSF
- Molgramostin
- Sargramostim
- Gene Name
- CSF2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011774|Granulocyte-macrophage colony-stimulating factor MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVI SEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITF ESFKENLKDFLLVIPFDCWEPVQE
- Number of residues
- 144
- Molecular Weight
- 16294.605
- Theoretical pI
- 4.93
- GO Classification
- Functionsgranulocyte macrophage colony-stimulating factor receptor bindingProcessesactivation of MAPKK activity / axon guidance / cellular response to lipopolysaccharide / dendritic cell differentiation / embryonic placenta development / epidermal growth factor receptor signaling pathway / epithelial fluid transport / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / insulin receptor signaling pathway / macrophage activation / MAPK cascade / myeloid dendritic cell differentiation / negative regulation of cytolysis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / neurotrophin TRK receptor signaling pathway / positive regulation of cell proliferation / positive regulation of DNA replication / positive regulation of gene expression / positive regulation of interleukin-23 production / positive regulation of macrophage derived foam cell differentiation / positive regulation of podosome assembly / positive regulation of tyrosine phosphorylation of Stat5 protein / Ras protein signal transduction / small GTPase mediated signal transduction / vascular endothelial growth factor receptor signaling pathwayComponentsextracellular region / extracellular space / intracellular
- General Function
- Granulocyte macrophage colony-stimulating factor receptor binding
- Specific Function
- Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
- Pfam Domain Function
- GM_CSF (PF01109)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0011775|Granulocyte-macrophage colony-stimulating factor (CSF2) ATGTGGCTGCAGAGCCTGCTGCTCTTGGGCACTGTGGCCTGCAGCATCTCTGCACCCGCC CGCTCGCCCAGCCCCAGCACGCAGCCCTGGGAGCATGTGAATGCCATCCAGGAGGCCCGG CGTCTCCTGAACCTGAGTAGAGACACTGCTGCTGAGATGAATGAAACAGTAGAAGTCATC TCAGAAATGTTTGACCTCCAGGAGCCGACCTGCCTACAGACCCGCCTGGAGCTGTACAAG CAGGGCCTGCGGGGCAGCCTCACCAAGCTCAAGGGCCCCTTGACCATGATGGCCAGCCAC TACAAGCAGCACTGCCCTCCAACCCCGGAAACTTCCTGTGCAACCCAGATTATCACCTTT GAAAGTTTCAAAGAGAACCTGAAGGACTTTCTGCTTGTCATCCCCTTTGACTGCTGGGAG CCAGTCCAGGAGTGA
- Chromosome Location
- 5
- Locus
- 5q31.1
- External Identifiers
Resource Link UniProtKB ID P04141 UniProtKB Entry Name CSF2_HUMAN GenBank Gene ID M13207 GenAtlas ID CSF2 HGNC ID HGNC:2434 - General References
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- Cantrell MA, Anderson D, Cerretti DP, Price V, McKereghan K, Tushinski RJ, Mochizuki DY, Larsen A, Grabstein K, Gillis S, et al.: Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6250-4. [Article]
- Wong GG, Witek JS, Temple PA, Wilkens KM, Leary AC, Luxenberg DP, Jones SS, Brown EL, Kay RM, Orr EC, et al.: Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science. 1985 May 17;228(4701):810-5. [Article]
- Miyatake S, Otsuka T, Yokota T, Lee F, Arai K: Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J. 1985 Oct;4(10):2561-8. [Article]
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- Kaushansky K, Lopez JA, Brown CB: Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells. Biochemistry. 1992 Feb 18;31(6):1881-6. [Article]
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- Hansen G, Hercus TR, McClure BJ, Stomski FC, Dottore M, Powell J, Ramshaw H, Woodcock JM, Xu Y, Guthridge M, McKinstry WJ, Lopez AF, Parker MW: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell. 2008 Aug 8;134(3):496-507. doi: 10.1016/j.cell.2008.05.053. [Article]