Interleukin-6
Details
- Name
- Interleukin-6
- Synonyms
- B-cell stimulatory factor 2
- BSF-2
- CDF
- CTL differentiation factor
- Hybridoma growth factor
- IFN-beta-2
- IFNB2
- IL-6
- Interferon beta-2
- Gene Name
- IL6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0021838|Interleukin-6 MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
- Number of residues
- 212
- Molecular Weight
- 23717.965
- Theoretical pI
- 6.52
- GO Classification
- Functionscytokine activity / growth factor activity / interleukin-6 receptor bindingProcessesacute-phase response / aging / bone remodeling / branching involved in salivary gland morphogenesis / cell growth / cell redox homeostasis / cellular response to dexamethasone stimulus / cellular response to hydrogen peroxide / cellular response to interleukin-1 / cellular response to lipopolysaccharide / cellular response to tumor necrosis factor / cytokine-mediated signaling pathway / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / defense response to protozoan / defense response to virus / endocrine pancreas development / epithelial cell proliferation involved in salivary gland morphogenesis / glucagon secretion / glucose homeostasis / hepatic immune response / humoral immune response / inflammatory response / interleukin-6-mediated signaling pathway / monocyte chemotaxis / muscle cell cellular homeostasis / negative regulation of apoptotic process / negative regulation of cell proliferation / negative regulation of chemokine biosynthetic process / negative regulation of collagen biosynthetic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of cytokine secretion / negative regulation of fat cell differentiation / negative regulation of gluconeogenesis / negative regulation of hormone secretion / negative regulation of lipid storage / negative regulation of muscle organ development / negative regulation of neuron death / negative regulation of protein kinase activity / neuron projection development / neutrophil apoptotic process / neutrophil mediated immunity / platelet activation / positive regulation of acute inflammatory response / positive regulation of apoptotic process / positive regulation of B cell activation / positive regulation of cell proliferation / positive regulation of chemokine production / positive regulation of DNA replication / positive regulation of epithelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of immunoglobulin secretion / positive regulation of interleukin-6 production / positive regulation of JAK-STAT cascade / positive regulation of leukocyte chemotaxis / positive regulation of MAPK cascade / positive regulation of neuron differentiation / positive regulation of nitric oxide biosynthetic process / positive regulation of osteoblast differentiation / positive regulation of peptidyl-serine phosphorylation / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of protein import into nucleus, translocation / positive regulation of protein kinase B signaling / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of smooth muscle cell proliferation / positive regulation of STAT protein import into nucleus / positive regulation of T cell proliferation / positive regulation of T-helper 2 cell differentiation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of translation / positive regulation of transmission of nerve impulse / positive regulation of type B pancreatic cell apoptotic process / positive regulation of tyrosine phosphorylation of Stat3 protein / regulation of angiogenesis / regulation of cell shape / regulation of circadian sleep/wake cycle, non-REM sleep / regulation of vascular endothelial growth factor production / response to amino acid / response to antibiotic / response to auditory stimulus / response to caffeine / response to calcium ion / response to cold / response to drug / response to electrical stimulus / response to glucocorticoid / response to heat / response to insulin / response to nutrient levels / response to peptidoglycan / response to yeast / T-helper 17 cell lineage commitmentComponentscytoplasm / external side of plasma membrane / extracellular region / extracellular space / interleukin-6 receptor complex
- General Function
- Interleukin-6 receptor binding
- Specific Function
- Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
- Pfam Domain Function
- IL6 (PF00489)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0021839|Interleukin-6 (IL6) ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC AGAGCTGTGCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG
- Chromosome Location
- 7
- Locus
- 7p21
- External Identifiers
Resource Link UniProtKB ID P05231 UniProtKB Entry Name IL6_HUMAN GenBank Protein ID 32674 GenBank Gene ID X04430 GenAtlas ID IL6 HGNC ID HGNC:6018 - General References
- Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, et al.: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986 Nov 6-12;324(6092):73-6. [Article]
- Yasukawa K, Hirano T, Watanabe Y, Muratani K, Matsuda T, Nakai S, Kishimoto T: Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 1987 Oct;6(10):2939-45. [Article]
- May LT, Helfgott DC, Sehgal PB: Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8957-61. [Article]
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- Tonouchi N, Miwa K, Karasuyama H, Matsui H: Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells. Biochem Biophys Res Commun. 1989 Sep 15;163(2):1056-62. [Article]
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- Ming JE, Cernetti C, Steinman RM, Granelli-Piperno A: Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium. J Mol Cell Immunol. 1989;4(4):203-11; discussion 211-2. [Article]
- May LT, Shaw JE, Khanna AK, Zabriskie JB, Sehgal PB: Marked cell-type-specific differences in glycosylation of human interleukin-6. Cytokine. 1991 May;3(3):204-11. [Article]
- Breton J, La Fiura A, Bertolero F, Orsini G, Valsasina B, Ziliotto R, De Filippis V, Polverino de Laureto P, Fontana A: Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond. Eur J Biochem. 1995 Jan 15;227(1-2):573-81. [Article]
- Clogston CL, Boone TC, Crandall BC, Mendiaz EA, Lu HS: Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor. Arch Biochem Biophys. 1989 Jul;272(1):144-51. [Article]
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- Nishimura C, Watanabe A, Gouda H, Shimada I, Arata Y: Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy. Biochemistry. 1996 Jan 9;35(1):273-81. [Article]
- Xu GY, Yu HA, Hong J, Stahl M, McDonagh T, Kay LE, Cumming DA: Solution structure of recombinant human interleukin-6. J Mol Biol. 1997 May 2;268(2):468-81. [Article]
- Somers W, Stahl M, Seehra JS: 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J. 1997 Mar 3;16(5):989-97. [Article]
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- Foster CB, Lehrnbecher T, Samuels S, Stein S, Mol F, Metcalf JA, Wyvill K, Steinberg SM, Kovacs J, Blauvelt A, Yarchoan R, Chanock SJ: An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus. Blood. 2000 Oct 1;96(7):2562-7. [Article]
- Ota N, Nakajima T, Nakazawa I, Suzuki T, Hosoi T, Orimo H, Inoue S, Shirai Y, Emi M: A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet. 2001;46(5):267-72. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01404 Ginseng investigational, nutraceutical unknown antagonist Details DB05017 YSIL6 investigational unknown Details DB05470 VX-702 investigational unknown Details DB05744 CRx-139 investigational unknown Details DB05767 Andrographolide investigational unknown Details DB11967 Binimetinib approved, investigational unknown Details DB05513 Atiprimod investigational unknown Details DB09036 Siltuximab approved, investigational yes antagonistantibody Details DB12140 Dilmapimod investigational unknown Details DB09221 Polaprezinc experimental unknown inhibitor Details DB10770 Foreskin fibroblast (neonatal) approved unknown agonist Details DB10772 Foreskin keratinocyte (neonatal) approved yes agonist Details DB13127 Olokizumab investigational yes antagonist Details