Neuraminidase
Details
- Name
- Neuraminidase
- Synonyms
- 3.2.1.18
- Gene Name
- NA
- Organism
- Influenza A virus (strain A/Bangkok/1/1979 H3N2)
- Amino acid sequence
>lcl|BSEQ0009907|Neuraminidase MNPNQKIITIGSVSLTIATICFLMQIAILVTTVTLHFKQYECSSPPNNQVMPCEPIIIER NITEIVYLTNTTIDKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGGIWVTREP YVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRTPYRTLLMNELGVPFHLGTRQVCIAWSS SSCHDGKAWLHVCVTGYDKNATASFIYDGRLVDSIGSWSKNILRTQESECVCINGTCTVV MTDGSASERADTKILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNR PVVDINVKDYSIVSSYVCSGLVGDTPRKNDRSSSSYCRNPNNEKGNHGVKGWAFDDGNDV WMGRTISEESRSGYETFKVIGGWSTPNSKLQINRQVIVDSDNRSGYSGIFSVEGKSCINR CFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
- Number of residues
- 469
- Molecular Weight
- 52140.54
- Theoretical pI
- 7.28
- GO Classification
- Functionsexo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activity / metal ion bindingProcessescarbohydrate metabolic processComponentshost cell plasma membrane / integral component of membrane / virion membrane
- General Function
- Metal ion binding
- Specific Function
- Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
- Pfam Domain Function
- Neur (PF00064)
- Transmembrane Regions
- 7-35
- Cellular Location
- Virion membrane
- Gene sequence
>lcl|BSEQ0000113|1410 bp ATGAATCCAAATCAAAAGATAATAACAATTGGCTCTGTCTCTCTCACCATTGCAACAATA TGCTTCCTTATGCAAATTGCCATCCTGGTAACTACTGTAACATTGCATTTCAAGCAATAT GAGTGCAGCTCCCCCCCAAACAACCAAGTAATGCCGTGTGAACCAATAATAATAGAAAGA AACATAACAGAGATAGTGTATTTGACTAACACCACCATAGACAAAGAGATATGCCCCAAA TTAGTGGAATACAGAAATTGGTCAAAGCCGCAATGTAAAATTACAGGATTTGCACCTTTT TCTAAGGACAATTCAATTCGGCTTTCTGCTGGTGGGGGCATTTGGGTGACGAGAGAACCT TATGTGTCATGCGATCCTGGCAAGTGTTATCAATTTGCACTCGGGCAGGGGACCACACTA GACAACAAGCATTCAAATGACACAATACATGATAGGACCCCTTATCGAACCCTATTGATG AATGAGTTGGGTGTTCCATTTCATTTGGGAACCAGGCAAGTGTGTATAGCATGGTCCAGC TCAAGTTGTCACGATGGAAAAGCATGGCTGCATGTTTGTGTCACTGGGTATGATAAAAAT GCAACTGCTAGCTTCATTTACGATGGGAGGCTTGTAGACAGTATTGGTTCATGGTCCAAA AATATCCTCAGGACCCAGGAGTCGGAATGCGTTTGTATCAATGGGACTTGTACAGTAGTA ATGACTGATGGAAGTGCTTCAGAAAGAGCTGATACTAAAATACTATTCATTGAAGAGGGG AAAATCGTTCATATTAGCCCATTGTCAGGAAGTGCTCAGCATGTAGAGGAGTGTTCCTGT TATCCTCGATATCCTGGTGTCAGATGTGTCTGCAGAGACAACTGGAAAGGCTCCAATAGG CCCGTCGTAGATATAAATGTGAAAGATTATAGCATTGTTTCCAGTTATGTGTGCTCAGGG CTTGTTGGCGACACACCCAGAAAAAACGACAGATCTAGCAGTAGCTATTGCCGGAATCCT AACAATGAGAAAGGGAATCATGGAGTGAAAGGCTGGGCCTTTGACGATGGAAATGACGTG TGGATGGGAAGAACGATCAGCGAGGAGTCACGATCAGGTTATGAAACCTTCAAAGTCATT GGTGGTTGGTCCACACCTAATTCCAAATTGCAGATAAATAGGCAAGTCATAGTTGACAGC GATAATAGGTCCGGTTATTCTGGTATTTTCTCTGTTGAGGGCAAAAGCTGCATCAATAGG TGCTTTTATGTGGAGTTGATAAGGGGAAGGGAACAGGAAACTAGAGTCTGGTGGACCTCA AACAGTATTGTTGTGTTTTGTGGCACTTCAGGTACCTATGGAACAGGCTCATGGCCTGAT GGAGCGGACATCAATCTCATGCCTATATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06818 UniProtKB Entry Name NRAM_I79A0 GenBank Protein ID 324460 GenBank Gene ID K01150 - General References
- Martinez C, del Rio L, Portela A, Domingo E, Ortin J: Evolution of the influenza virus neuraminidase gene during drift of the N2 subtype. Virology. 1983 Oct 30;130(2):539-45. [Article]
- Nayak DP, Hui EK, Barman S: Assembly and budding of influenza virus. Virus Res. 2004 Dec;106(2):147-65. [Article]
- Moscona A: Neuraminidase inhibitors for influenza. N Engl J Med. 2005 Sep 29;353(13):1363-73. [Article]
- Suzuki Y: Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull. 2005 Mar;28(3):399-408. [Article]