ATP-dependent translocase ABCB1

Details

Name
ATP-dependent translocase ABCB1
Synonyms
  • ATP-binding cassette sub-family B member 1
  • MDR1
  • Multidrug resistance protein 1
  • P-glycoprotein 1
  • PGY1
  • Phospholipid transporter ABCB1
Gene Name
ABCB1
UniProtKB Entry
P08183Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037114|ATP-dependent translocase ABCB1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ
Number of residues
1280
Molecular Weight
141477.255
Theoretical pI
9.44
GO Classification
Functions
ABC-type xenobiotic transporter activity / ATP hydrolysis activity / ATPase-coupled transmembrane transporter activity / carboxylic acid transmembrane transporter activity / ceramide floppase activity / efflux transmembrane transporter activity / floppase activity / phosphatidylcholine floppase activity / phosphatidylethanolamine flippase activity / transmembrane transporter activity / ubiquitin protein ligase binding / xenobiotic transmembrane transporter activity
Processes
carboxylic acid transmembrane transport / ceramide translocation / export across plasma membrane / phospholipid translocation / positive regulation of anion channel activity / regulation of chloride transport / regulation of response to osmotic stress / response to xenobiotic stimulus / terpenoid transport / transepithelial transport / transport across blood-brain barrier / xenobiotic detoxification by transmembrane export across the plasma membrane / xenobiotic metabolic process / xenobiotic transport across blood-brain barrier
Components
apical plasma membrane / cytoplasm / external side of apical plasma membrane
General Function
Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
Specific Function
ABC-type xenobiotic transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
45-67 117-137 187-208 216-236 293-316 331-352 712-732 757-777 833-853 855-874 935-957 974-995
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016291|Multidrug resistance protein 1 (ABCB1)
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCC
AAGATTAATGAAGGAATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGTCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTTCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATTGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA
Chromosome Location
7
Locus
7q21.12
External Identifiers
ResourceLink
UniProtKB IDP08183
UniProtKB Entry NameMDR1_HUMAN
GenBank Protein ID307180
GenBank Gene IDM14758
GeneCard IDABCB1
GenAtlas IDABCB1
HGNC IDHGNC:40
PDB ID(s)6C0V, 6FN1, 6FN4, 6QEX, 7A65, 7A69, 7A6C, 7A6E, 7A6F, 7O9W, 8Y6H, 8Y6I
KEGG IDhsa:5243
IUPHAR/Guide To Pharmacology ID768
NCBI Gene ID5243
General References
  1. Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell. 1986 Nov 7;47(3):381-9. [Article]
  2. Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB: Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem. 1990 Jan 5;265(1):506-14. [Article]
  3. Chen G, Duran GE, Steger KA, Lacayo NJ, Jaffrezou JP, Dumontet C, Sikic BI: Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. J Biol Chem. 1997 Feb 28;272(9):5974-82. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
  6. Gekeler V, Weger S, Probst H: mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles. Biochem Biophys Res Commun. 1990 Jun 15;169(2):796-802. [Article]
  7. Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K: P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochem Biophys Res Commun. 1989 Jul 14;162(1):224-31. [Article]
  8. Kerb R, Hoffmeyer S, Brinkmann U: ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics. 2001 Feb;2(1):51-64. [Article]
  9. Begley GS, Horvath AR, Taylor JC, Higgins CF: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. Mol Immunol. 2005 Jan;42(1):137-41. [Article]
  10. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  11. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  12. Katayama K, Yamaguchi M, Noguchi K, Sugimoto Y: Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function. Cancer Lett. 2014 Apr 1;345(1):124-31. doi: 10.1016/j.canlet.2013.12.007. Epub 2013 Dec 11. [Article]
  13. Choi KH, Chen CJ, Kriegler M, Roninson IB: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell. 1988 May 20;53(4):519-29. [Article]
  14. Mickley LA, Lee JS, Weng Z, Zhan Z, Alvarez M, Wilson W, Bates SE, Fojo T: Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. Blood. 1998 Mar 1;91(5):1749-56. [Article]
  15. Decleves X, Chevillard S, Charpentier C, Vielh P, Laplanche JL: A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein. Hum Mutat. 2000 May;15(5):486. [Article]
  16. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8. [Article]
  17. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther. 2001 Mar;69(3):169-74. [Article]
  18. Honda T, Dan Y, Koyabu N, Ieiri I, Otsubo K, Higuchi S, Ohtani H, Sawada Y: Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys). Drug Metab Pharmacokinet. 2002;17(5):479-81. [Article]
  19. Itoda M, Saito Y, Komamura K, Ueno K, Kamakura S, Ozawa S, Sawada J: Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone. Drug Metab Pharmacokinet. 2002;17(6):566-71. [Article]
  20. Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47(1):38-50. [Article]
  21. Brant SR, Panhuysen CI, Nicolae D, Reddy DM, Bonen DK, Karaliukas R, Zhang L, Swanson E, Datta LW, Moran T, Ravenhill G, Duerr RH, Achkar JP, Karban AS, Cho JH: MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet. 2003 Dec;73(6):1282-92. Epub 2003 Nov 7. [Article]
  22. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]

Associated Data

Bio-Entities
Bio-EntityType
ATP-dependent translocase ABCB1 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
ATPinvestigational, nutraceuticalunknowntargetDetails
Roxithromycinapproved, investigational, withdrawnunknowntargetDetails
ElacridarinvestigationalyestargetinhibitorDetails
TesmilifeneinvestigationalyestargetinducerDetails
FM-VP4investigationalunknowntargetDetails
TariquidarinvestigationalyestargetmodulatorDetails
ZosuquidarinvestigationalyestargetinhibitorDetails
VerapamilapprovedunknowntransportersubstrateinhibitorDetails
Saquinavirapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
NelfinavirapprovednotransportersubstrateinhibitorinducerDetails
IndinavirapprovedunknowntransportersubstrateinhibitorinducerDetails
Amprenavirapproved, investigationalunknowntransportersubstrateinducerDetails
RifampinapprovedunknowntransporterinducerDetails
Reserpineapproved, investigational, withdrawnunknowntransportersubstrateinhibitorinducerDetails
NifedipineapprovedunknowntransportersubstrateinducerDetails
Mifepristoneapproved, investigationalunknowntransporterinhibitorinducerDetails
Dexamethasoneapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorinducerDetails
Clotrimazoleapproved, vet_approvedunknowntransporterinhibitorinducerDetails
Carbamazepineapproved, investigationalunknowntransporterinducerDetails
Trazodoneapproved, investigationalunknowntransporterinducerDetails
Nefazodoneapproved, withdrawnunknowntransporterinhibitorinducerDetails
Ritonavirapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
DigoxinapprovedunknowntransportersubstrateinhibitorinducerDetails
Liothyronineapproved, vet_approvedunknowntransporterinducerDetails
LevothyroxineapprovedunknowntransporterinducerDetails
Trimethoprimapproved, vet_approvedunknowntransportersubstrateDetails
Progesteroneapproved, vet_approvedunknowntransportersubstrateinhibitorinducerDetails
Platelet Activating FactorexperimentalunknowntransportersubstrateinducerDetails
Cyclosporineapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Cimetidineapproved, investigationalunknowntransportersubstrateinducerDetails
Aldosteroneexperimental, investigationalunknowntransportersubstrateinducerDetails
Tacrolimusapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
Sirolimusapproved, investigationalnotransportersubstrateinhibitorinducerDetails
Phenobarbitalapproved, investigationalunknowntransportersubstrateinducerDetails
Erythromycinapproved, investigational, vet_approvednotransportersubstrateinhibitorDetails
Amiodaroneapproved, investigationalunknowntransporterinhibitorinducerDetails
St. John's Wortapproved, investigational, nutraceuticalunknowntransporterinducerDetails
Vincristineapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
VinblastineapprovedunknowntransportersubstrateinhibitorinducerDetails
Cholic AcidapprovedunknowntransporterinducerDetails
TamoxifenapprovedunknowntransportersubstrateinhibitorinducerDetails
Streptozocinapproved, investigationalunknowntransporterinducerDetails
Mitoxantroneapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
Doxorubicinapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
DaunorubicinapprovedunknowntransportersubstrateinhibitorinducerDetails
Quinidineapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ketoconazoleapproved, investigationalunknowntransporterinhibitorDetails
Mibefradilinvestigational, withdrawnunknowntransportersubstrateinhibitorDetails
Cholesterolapproved, investigationalunknowntransporterinhibitorDetails
Mefloquineapproved, investigationalunknowntransportersubstrateinhibitorDetails
Nicardipineapproved, investigationalunknowntransportersubstrateinhibitorDetails
AmlodipineapprovedunknowntransportersubstrateinhibitorDetails
AzelastineapprovedunknowntransporterinhibitorDetails
Ranitidineapproved, withdrawnunknowntransportersubstrateinhibitorDetails
EtoposideapprovedunknowntransportersubstrateinhibitorDetails
MethadoneapprovedunknowntransporterinhibitorDetails
SimvastatinapprovedunknowntransporterinhibitorDetails
Lovastatinapproved, investigationalunknowntransporterinhibitorDetails
AtorvastatinapprovednotransportersubstrateinhibitorDetails
Paclitaxelapproved, vet_approvedunknowntransportersubstrateinhibitorDetails
PrazosinapprovedunknowntransportersubstrateinhibitormodulatorDetails
Nitrendipineapproved, investigationalunknowntransporterinhibitorDetails
DipyridamoleapprovedunknowntransportersubstrateinhibitorDetails
Diltiazemapproved, investigationalunknowntransportersubstrateinhibitorDetails
ColchicineapprovedunknowntransportersubstrateinducerDetails
ClarithromycinapprovedunknowntransportersubstrateinhibitorDetails
Chlorpromazineapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Dactinomycinapproved, investigationalunknowntransportersubstrateinhibitorDetails
TroleandomycinapprovedunknowntransporterinhibitorDetails
Trifluoperazineapproved, investigationalunknowntransporterinhibitorDetails
Terfenadineapproved, withdrawnunknowntransporterinhibitorDetails
QuinineapprovedunknowntransportersubstrateinhibitorDetails
Itraconazoleapproved, investigationalunknowntransporterinhibitorDetails
Indomethacinapproved, investigationalunknowntransportersubstrateinhibitorDetails
Colforsinexperimental, investigationalunknowntransporterinhibitorDetails
FluphenazineapprovedunknowntransporterinhibitorDetails
Felodipineapproved, investigationalunknowntransporterinhibitorDetails
Carvedilolapproved, investigationalunknowntransporterinhibitorDetails
SpironolactoneapprovedunknowntransporterinducerDetails
Lidocaineapproved, vet_approvedunknowntransporterinhibitorDetails
Ciprofloxacinapproved, investigationalunknowntransportersubstrateDetails
AzithromycinapprovedunknowntransportersubstrateinhibitorDetails
AcetaminophenapprovedunknowntransportersubstrateinhibitorDetails
Fluconazoleapproved, investigationalunknowntransporterinhibitorDetails
PantoprazoleapprovedunknowntransportersubstrateinhibitorDetails
Omeprazoleapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Lansoprazoleapproved, investigationalunknowntransportersubstrateinhibitorDetails
LosartanapprovedunknowntransportersubstrateinhibitorDetails
Enalaprilapproved, vet_approvedunknowntransporterinhibitorDetails
DoxazosinapprovedunknowntransporterinhibitorDetails
CilazaprilapprovedunknowntransporterinhibitorDetails
CaptoprilapprovedunknowntransporterinhibitorDetails
Candesartan cilexetilapprovedunknowntransporterinhibitorDetails
Miconazoleapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
ErgotamineapprovedunknowntransporterinhibitorDetails
ErgometrineapprovedunknowntransporterinhibitorDetails
Dihydroergotamineapproved, investigationalunknowntransporterinhibitorDetails
Bromocriptineapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
LoperamideapprovedunknowntransportersubstrateDetails
Fentanylapproved, illicit, investigational, vet_approvedunknowntransporterinhibitorDetails
Alfentanilapproved, illicitunknowntransporterinhibitorDetails
NisoldipineapprovedunknowntransporterinhibitorDetails
Zimelidineapproved, withdrawnunknowntransporterinhibitorDetails
Tacrineapproved, investigational, withdrawnunknowntransportersubstrateDetails
Sumatriptanapproved, investigationalunknowntransportersubstrateDetails
Selegilineapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
ImipramineapprovedunknowntransportersubstrateDetails
HaloperidolapprovedunknowntransportersubstrateinhibitorDetails
Fluvoxamineapproved, investigationalunknowntransporterinhibitorDetails
Flurazepamapproved, illicit, investigationalunknowntransporterinhibitorDetails
Fluoxetineapproved, vet_approvedunknowntransporterinhibitorDetails
Doxepinapproved, investigationalunknowntransportersubstrateDetails
Desipramineapproved, investigationalunknowntransporterinhibitorDetails
Clomipramineapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Chlorprothixeneapproved, experimental, investigational, withdrawnunknowntransporterinhibitorDetails
Buspironeapproved, investigationalunknowntransporterinhibitorDetails
PimozideapprovedunknowntransporterinhibitorDetails
Morphineapproved, investigationalnotransportersubstrateDetails
Ivermectinapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorinducerDetails
Hydrocortisoneapproved, vet_approvedunknowntransportersubstrateinducerDetails
Astemizoleapproved, withdrawnunknowntransporterinhibitorDetails
Triflupromazineapproved, vet_approvedunknowntransporterinhibitorDetails
ProtriptylineapprovedunknowntransporterinhibitorDetails
Promethazineapproved, investigationalunknowntransporterinhibitorDetails
Bepridilapproved, withdrawnunknowntransporterinhibitorDetails
Loratadineapproved, investigationalnotransportersubstrateinhibitorDetails
Desloratadineapproved, investigationalunknowntransporterinhibitorDetails
VenlafaxineapprovedunknowntransportersubstrateinhibitorDetails
SertralineapprovedunknowntransporterinhibitorDetails
Reboxetineapproved, experimentalunknowntransporterinhibitorDetails
Paroxetineapproved, investigationalunknowntransporterinhibitorDetails
CitalopramapprovedunknowntransportersubstrateinhibitorDetails
Estramustineapproved, investigationalunknowntransporterinhibitorDetails
Taurocholic acidapproved, experimentalunknowntransportersubstrateinhibitorDetails
Flupentixolapproved, investigational, withdrawnunknowntransporterinhibitorDetails
Megestrol acetateapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
StaurosporineexperimentalunknowntransporterinhibitorDetails
QuinacrineinvestigationalunknowntransporterinhibitorDetails
GenisteininvestigationalunknowntransporterinhibitorDetails
Quercetinexperimental, investigationalunknowntransporterinhibitorDetails
Levofloxacinapproved, investigationalunknowntransportersubstrateinhibitorDetails
NaringeninexperimentalunknowntransporterdownregulatorDetails
GlyburideapprovedunknowntransporterinhibitorDetails
Fexofenadineapproved, investigationalunknowntransportersubstrateDetails
TrimipramineapprovedunknowntransportersubstrateDetails
Propranololapproved, investigationalunknowntransportersubstrateDetails
Prednisoneapproved, vet_approvedunknowntransportersubstrateinducerDetails
Amsacrineapproved, investigationalunknowntransporterinhibitorDetails
Gramicidin DapprovedunknowntransportersubstrateinhibitorDetails
Benzocaineapproved, investigationalunknowntransporterinhibitorDetails
LopinavirapprovedunknowntransporterinhibitorinducerDetails
CaspofunginapprovedunknowntransporterinhibitorDetails
PravastatinapprovednotransportersubstrateDetails
ImatinibapprovednotransportersubstrateinhibitorDetails
Sorafenibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Sunitinibapproved, investigationalunknowntransporterinhibitorDetails
TerazosinapprovedunknowntransporterinhibitorDetails
Dronabinolapproved, illicitunknowntransporterinhibitorDetails
Buprenorphineapproved, illicit, investigational, vet_approvedunknowntransporterinhibitorDetails
Telmisartanapproved, investigationalunknowntransporterinhibitorDetails
Dasatinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Gefitinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Nilotinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
EstroneapprovedunknowntransportersubstrateinducerDetails
Lapatinibapproved, investigationalunknowntransporterinhibitorDetails
Posaconazoleapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Grepafloxacinapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
Diazepamapproved, illicit, investigational, vet_approvedunknowntransportersubstrateDetails
Digitoxinapproved, investigationalunknowntransportersubstrateDetails
Sparfloxacinapproved, investigational, withdrawnunknowntransportersubstrateDetails
Methylprednisoloneapproved, vet_approvedunknowntransportersubstrateinducerDetails
QuetiapineapprovedunknowntransportersubstrateDetails
Olanzapineapproved, investigationalnotransportersubstrateDetails
ClozapineapprovedunknowntransportersubstrateDetails
Naloxoneapproved, vet_approvedunknowntransportersubstrateDetails
CamptothecinexperimentalunknowntransportersubstrateDetails
Prednisoloneapproved, vet_approvedunknowntransportersubstrateDetails
Acebutololapproved, investigationalunknowntransportersubstrateDetails
IbuprofenapprovedunknowntransportersubstrateDetails
Acetylsalicylic acidapproved, vet_approvedunknowntransportersubstrateinducermodulatorDetails
Domperidoneapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Betamethasoneapproved, vet_approvedunknowntransportersubstrateDetails
Toremifeneapproved, investigationalunknowntransportersubstrateDetails
Diethylstilbestrolapproved, investigational, withdrawnunknowntransportersubstrateDetails
Clomifeneapproved, investigationalunknowntransportersubstrateDetails
Estradiolapproved, investigational, vet_approvedunknowntransportersubstratedownregulatorregulatorDetails
Docetaxelapproved, investigationalunknowntransportersubstrateDetails
MethotrexateapprovedunknowntransportersubstrateDetails
TimololapprovedunknowntransportersubstrateDetails
NadololapprovedunknowntransportersubstrateDetails
Alitretinoinapproved, investigationalunknowntransportersubstrateDetails
Vecuroniumapproved, investigationalunknowntransportersubstrateDetails
Debrisoquineapproved, investigationalunknowntransportersubstrateDetails
GemcitabineapprovednotransportersubstrateDetails
Topotecanapproved, investigationalunknowntransportersubstrateDetails
Stanoloneillicit, investigationalunknowntransportersubstrateDetails
Epinastineapproved, investigationalunknowntransportersubstrateDetails
NorethisteroneapprovedunknowntransporterinhibitorDetails
Estriolapproved, investigational, vet_approvedunknowntransportersubstrateinducerDetails
SphingosineexperimentalunknowntransportersubstrateDetails
Cerivastatinapproved, withdrawnunknowntransportersubstrateDetails
Conjugated estrogensapprovedunknowntransportersubstrateDetails
LevetiracetamapprovedunknowntransportersubstrateDetails
Phenytoinapproved, vet_approvedunknowntransportersubstrateDetails
NizatidineapprovedunknowntransportersubstrateDetails
Erlotinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Lamotrigineapproved, investigationalunknowntransportersubstrateinhibitorDetails
Sitagliptinapproved, investigationalunknowntransportersubstrateDetails
Atazanavirapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
Arsenic trioxideapproved, investigationalunknowntransporterinhibitorDetails
CabazitaxelapprovedunknowntransportersubstrateinhibitorDetails
LiotrixapprovedunknowntransporterinducerDetails
TemsirolimusapprovedunknowntransportersubstrateinhibitorDetails
KetazolamapprovedunknowntransportersubstrateDetails
VoacamineexperimentalunknowntargetinhibitorDetails
EthinylestradiolapprovedunknowntransportersubstrateDetails
PropafenoneapprovedunknowntransporterinhibitorDetails
Eletriptanapproved, investigationalunknowntransportersubstrateDetails
DronedaroneapprovednotransporterinhibitorDetails
Romidepsinapproved, investigationalunknowntransportersubstrateDetails
SilodosinapprovedunknowntransportersubstrateDetails
EtravirineapprovedunknowntransporterinhibitorDetails
RivaroxabanapprovedunknowntransportersubstrateDetails
Dabigatran etexilateapprovedunknowntransportersubstrateDetails
EzetimibeapprovedunknowntransportersubstrateDetails
FesoterodineapprovedunknowntransportersubstrateDetails
TolvaptanapprovednotransportersubstrateinhibitorDetails
PitavastatinapprovedunknowntransportersubstrateDetails
PazopanibapprovedunknowntransportersubstrateDetails
RilpivirineapprovedunknowntransporterinhibitorDetails
Boceprevirapproved, withdrawnunknowntransporterinhibitorDetails
Telaprevirapproved, withdrawnunknowntransportersubstrateinhibitorDetails
FidaxomicinapprovednotransportersubstrateDetails
IndacaterolapprovedunknowntransportersubstrateDetails
Clobazamapproved, illicitnotransportersubstrateDetails
LinagliptinapprovedunknowntransportersubstrateDetails
Lomitapideapproved, investigationalnotransporterinhibitorDetails
TicagrelorapprovedunknowntransportersubstrateinhibitorDetails
Crizotinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
ApixabanapprovedunknowntransportersubstrateDetails
Axitinibapproved, investigationalnotransportersubstrateinhibitorDetails
Vismodegibapproved, investigationalunknowntransportersubstrateDetails
Carfilzomibapproved, investigationalunknowntransportersubstrateinhibitorDetails
MirabegronapprovedunknowntransportersubstrateinhibitorDetails
RegorafenibapprovedunknowntransportersubstrateinhibitorDetails
EnzalutamideapprovednotransporterinhibitorDetails
IvacaftorapprovednotransporterinhibitorDetails
BosutinibapprovednotransportersubstrateDetails
Ponatinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Fluticasone furoateapprovednotransportersubstrateinducerDetails
CanagliflozinapprovedunknowntransportersubstrateinhibitorDetails
PomalidomideapprovedunknowntransportersubstrateDetails
LenalidomideapprovednotransportersubstrateDetails
Dabrafenibapproved, investigationalnotransportersubstrateDetails
Trastuzumab emtansineapproved, investigationalunknowntransportersubstrateDetails
ZidovudineapprovedunknowntransportersubstrateDetails
ClopidogrelapprovednotransportersubstrateDetails
AfatinibapprovedunknowntransportersubstrateinhibitorDetails
Irinotecanapproved, investigationalunknowntransportersubstrateDetails
Lamivudineapproved, investigationalunknowntransportersubstrateDetails
Mycophenolate mofetilapproved, investigationalunknowntransportersubstrateDetails
Levomilnacipranapproved, investigationalunknowntransportersubstrateDetails
SimeprevirapprovedunknowntransportersubstrateinhibitorDetails
SofosbuvirapprovednotransportersubstrateDetails
DapagliflozinapprovedunknowntransportersubstrateDetails
UmeclidiniumapprovednotransportersubstrateDetails
EdoxabanapprovednotransportersubstrateDetails
CeritinibapprovednotransportersubstrateDetails
Lenvatinibapproved, investigationalnotransportersubstrateinhibitorDetails
NintedanibapprovednotransportersubstrateinhibitorDetails
IdelalisibapprovednotransportersubstrateinhibitorDetails
CobicistatapprovedunknowntransporterinhibitorDetails
Rolapitantapproved, investigationalnotransporterinhibitorDetails
Daclatasvirapproved, investigationalunknowntransportersubstrateinhibitorDetails
Isavuconazoniumapproved, investigationalnotransporterinhibitorDetails
Panobinostatapproved, investigationalnotransportersubstrateDetails
OsimertinibapprovednotransportersubstrateDetails
SelexipagapprovednotransportersubstrateDetails
Ambrisentanapproved, investigationalunknowntransportersubstrateDetails
Ombitasvirapproved, investigationalnotransportersubstrateDetails
ElbasvirapprovednotransportersubstrateinhibitorDetails
GrazoprevirapprovednotransportersubstrateDetails
Technetium Tc-99m sestamibiapproved, investigationalnotransportersubstrateDetails
Venetoclaxapproved, investigationalnotransportersubstrateinhibitorDetails
Belinostatapproved, investigationalunknowntransportersubstrateDetails
Velpatasvirapproved, investigationalnotransportersubstrateinhibitorDetails
LedipasvirapprovednotransportersubstratetransporterDetails
LobeglitazoneexperimentalnotransporterDetails
Miltefosineapproved, investigationalunknowntargetDetails
LumacaftorapprovednotransporterinhibitorinducerDetails
Neratinibapproved, investigationalunknowntransporterinhibitorDetails
Voxilaprevirapproved, investigationalnotransportersubstrateinhibitorDetails
Enasidenibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Inotuzumab ozogamicinapproved, investigationalunknowntransportersubstrateDetails
Pibrentasvirapproved, investigationalunknowntransportersubstrateinhibitorDetails
Glecaprevirapproved, investigationalunknowntransportersubstrateinhibitorDetails
Copanlisibapproved, investigationalunknowntransportersubstrateDetails
Abemaciclibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Betrixabanapproved, investigationalnotransportersubstrateDetails
CandesartanexperimentalunknowntransporterinhibitorDetails
Letermovirapproved, investigationalnotransportersubstrateinhibitorDetails
Rucaparibapproved, investigationalnotransportersubstrateinhibitorDetails
Ubidecarenoneapproved, investigational, nutraceuticalnotransportersubstrateDetails
Ertugliflozinapproved, investigationalnotransportersubstrateDetails
Testosterone cypionateapprovedunknowntransporterinhibitorDetails
Testosterone enanthateapprovedunknowntransporterinhibitorDetails
Testosterone undecanoateapproved, investigationalunknowntransporterinhibitorDetails
Technetium Tc-99m tetrofosminapprovednocarrierbinderDetails
Stanolone acetateexperimentalunknowntransportersubstrateDetails
Estradiol acetateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Estradiol benzoateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Estradiol cypionateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Estradiol valerateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Testosterone propionateapproved, investigational, vet_approved, withdrawnnotransportersubstrateDetails
Apalutamideapproved, investigationalunknowntransporterinducerDetails
Isavuconazoleapproved, investigationalunknowntransporterinhibitorDetails
Tocopherolapproved, investigationalnotransportertransporterDetails
alpha-Tocopherol acetateapprovednotransportersubstrateDetails
Somatostatinapproved, investigationalunknowntransportersubstrateDetails
TocofersolanapprovedyestargetantagonistDetails
Vinflunineapproved, investigationalnotransportersubstrateDetails
Curcuminapproved, investigationalunknowntransporterinhibitorDetails
Avatrombopagapproved, investigationalnotransportersubstrateDetails
Paritaprevirapproved, investigationalunknowntransportersubstrateDetails
DasabuvirapprovedunknowntransportersubstrateDetails
Fentanylapproved, illicit, investigational, vet_approvedunknowntargetDetails
Concanamycin AexperimentalyestargetinhibitorDetails
HycanthoneexperimentalyestargetinhibitorDetails
DexverapamilexperimentalyestargetinhibitorDetails
EmopamilexperimentalyestargetinhibitorDetails
LomerizineexperimentalyestargetinhibitorDetails
TetrandrineexperimentalunknowntargetinhibitorDetails
Dofequidarexperimental, investigationalunknowntargetinhibitorDetails
DexniguldipineexperimentalunknowntargetinhibitorDetails
ONT-093investigationalyestargetinhibitorDetails
HM-30181experimentalyestargetinhibitorDetails
DesmethylsertralineexperimentalunknowntargetinhibitorDetails
Reversin 121experimentalyestargetinhibitorDetails
LoxicodegolinvestigationalunknowntransporterDetails
Hydrocortisone aceponateexperimental, vet_approvedunknowntransporterDetails
Hydrocortisone acetateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone butyrateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone cypionateapproved, investigational, vet_approvedunknowntransporterDetails
Hydrocortisone phosphateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone probutateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone valerateapproved, vet_approvedunknowntransporterDetails
Ivosidenibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Elagolixapproved, investigationalunknowntransportersubstrateinhibitorDetails
Fluticasoneapproved, experimentalnocarriersubstrateDetails
Chloroquineapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorDetails
Amodiaquineapproved, investigationalunknowntransporterinhibitorDetails
PrimaquineapprovedunknowntransporterinhibitorDetails
HydroxychloroquineapprovedunknowntransporterinhibitorDetails
PaliperidoneapprovedunknowntransportersubstrateinhibitorDetails
DovitinibinvestigationalunknowntransporterinhibitorDetails
Lusutrombopagapproved, investigationalunknowntransportersubstrateDetails
Curcumin sulfateexperimentalunknowntransporterDetails
Estriol tripropionateexperimentalunknowntransporterDetails
Duvelisibapproved, investigationalnotransportersubstrateDetails
Dexibuprofenapproved, investigationalunknowntransporterDetails
Talazoparibapproved, investigationalunknowntransportersubstrateDetails
Omadacyclineapproved, investigationalunknowntransportersubstrateDetails
Grapiprantinvestigational, vet_approvednotransportersubstrateDetails
Sarecyclineapproved, investigationalunknowntransporterinhibitorDetails
Rifamycinapproved, investigationalnotransportersubstrateinhibitorDetails
Dacomitinibapproved, investigationalnotransportersubstrateinhibitorDetails
Revefenacinapproved, investigationalnotransportersubstrateDetails
Gilteritinibapproved, investigationalnotransportersubstrateDetails
Tenofovirexperimental, investigationalnotransportersubstrateDetails
Tenofovir disoproxilapproved, investigationalunknowntransportersubstrateinhibitorDetails
Tenofovir alafenamideapprovedunknowntransportersubstrateDetails
DarunavirapprovedunknowntransportersubstrateinhibitorinducerDetails
Sildenafilapproved, investigationalunknowntransportersubstrateinhibitorDetails
VardenafilapprovedunknowntransportersubstrateinhibitorDetails
OxcarbazepineapprovedunknowntransportersubstrateDetails
CabergolineapprovednotransportersubstrateDetails
PrucaloprideapprovednotransportersubstrateDetails
Risperidoneapproved, investigationalunknowntransportersubstrateDetails
AtovaquoneapprovednotransporterinhibitorDetails
Naproxenapproved, vet_approvednotransporterinhibitorDetails
Rifabutinapproved, investigationalunknowntransporterinducerDetails
PiperineinvestigationalunknowntransporterinhibitorDetails
Glasdegibapproved, investigationalnotransportersubstrateinhibitorDetails
OlaparibapprovednotransportersubstrateinhibitorDetails
Ranolazineapproved, investigationalnotransportersubstrateinhibitorDetails
AmitriptylineapprovedunknowntransportersubstrateDetails
CetirizineapprovednotransportersubstrateinhibitorDetails
Palbociclibapproved, investigationalnotransportersubstrateinhibitorDetails
Tegaserodapproved, investigational, withdrawnunknowntransportersubstrateDetails
Fluticasoneapproved, experimentalunknowntransportersubstrateDetails
Erdafitinibapproved, investigationalnotransportersubstrateinhibitorDetails
Esomeprazoleapproved, investigationalunknowntransportersubstrateinhibitorDetails
DuloxetineapprovedunknowntransporterinhibitorDetails
Raloxifeneapproved, investigationalunknowntransportersubstrateDetails
Alpelisibapproved, investigationalunknowntransporterinhibitorDetails
Tezacaftorapproved, investigationalnotransportersubstrateinhibitorDetails
OlopatadineapprovednotransportersubstrateDetails
Nitrofurantoinapproved, vet_approvedunknowntransportersubstrateDetails
LevothyroxineapprovednoenzymeinducerDetails
Beclomethasone dipropionateapproved, investigationalunknowntransportersubstrateinducerDetails
BisoprololapprovedunknowntransportersubstrateinhibitorDetails
MetronidazoleapprovedunknowntransporterinhibitorDetails
Celecoxibapproved, investigationalunknowntransportersubstrateDetails
Entrectinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Fedratinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Lefamulinapproved, investigationalunknowntransportersubstrateDetails
BudesonideapprovednotransportersubstrateDetails
Istradefyllineapproved, investigationalunknowntransporterinhibitorDetails
Metoclopramideapproved, investigationalunknowntransportersubstrateDetails
EscitalopramapprovedunknowntransportersubstrateDetails
Medroxyprogesterone acetateapproved, investigationalunknowntargetinhibitorDetails
Anastrozoleapproved, investigationalunknowntransportersubstrateDetails
Flecainideapproved, withdrawnunknowntransportersubstrateDetails
Acenocoumarolapproved, investigationalunknowntransportersubstrateDetails
Apremilastapproved, investigationalunknowntransportersubstrateDetails
Lasmiditanapproved, investigationalunknowntransportersubstrateinhibitorDetails
Asunaprevirapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
Elexacaftorapproved, investigationalnotransportersubstrateinhibitorDetails
Prednisolone acetateapproved, vet_approvedunknowntransportersubstrateDetails
Zanubrutinibapproved, investigationalnotransportersubstrateDetails
TopiramateapprovedunknowntransportersubstrateDetails
Levamlodipineapproved, investigationalunknowntransportersubstrateDetails
Trastuzumab deruxtecanapproved, investigationalnotransportersubstrateDetails
Enfortumab vedotinapproved, investigationalunknowntransportersubstrateDetails
Lemborexantapproved, investigationalunknowntransportersubstrateDetails
Darolutamideapproved, investigationalunknowntransportersubstrateDetails
Upadacitinibapproved, investigationalnotransportersubstrateinhibitorDetails
Ubrogepantapproved, investigationalunknowntransportersubstrateDetails
Avapritinibapproved, investigationalunknowntransporterinhibitormodulatorDetails
AzathioprineapprovedunknowntransportersubstrateDetails
HydroxyzineapprovedunknowntransportersubstrateDetails
Polyethylene glycol 400approvedunknowntransporterinhibitorDetails
Tazemetostatapproved, investigationalunknowntransportersubstrateDetails
Letrozoleapproved, investigationalunknowntransportersubstrateDetails
ZiprasidoneapprovedunknowntransporterDetails
Clindamycinapproved, vet_approvedunknowntransportersubstrateDetails
Polyethylene glycolapproved, vet_approvednotransporterinhibitorDetails
Norgestimateapproved, investigationalunknowntransporterinhibitorDetails
TalinololinvestigationalunknowntransportersubstrateDetails
ElacridarinvestigationalunknowntransporterinhibitorDetails
Tipranavirapproved, investigationalunknowntransportersubstrateinhibitorinducerDetails
ValspodarinvestigationalunknowntransporterinhibitorDetails
Albendazoleapproved, vet_approvednotransportersubstrateDetails
Cobimetinibapproved, investigationalnotransportersubstrateDetails
OdanacatibinvestigationalunknowntransportersubstrateDetails
VoacamineexperimentalnotransporterinhibitorDetails
DolutegravirapprovednotransportersubstrateDetails
Diclofenacapproved, vet_approvedunknowntransporterinducerDetails
Baricitinibapproved, investigationalunknowntransportersubstrateDetails
Alectinibapproved, investigationalunknowntransporterinhibitorDetails
Larotrectinibapproved, investigationalnotransportersubstrateDetails
Fluticasone propionateapprovedunknowntransportersubstrateDetails
Monensinexperimental, vet_approvedunknowntransportersubstrateDetails
Rhodamine 6GexperimentalunknowntransportersubstrateDetails
NiguldipineexperimentalunknowntransporterinhibitorDetails
BiricodarinvestigationalunknowntransporterinhibitorDetails
TariquidarinvestigationalunknowntransporterinhibitorDetails
LaniquidarinvestigationalunknowntransporterinhibitorDetails
GallopamilinvestigationalunknowntransporterinhibitorDetails
AnnamycininvestigationalunknowntransporterDetails
NortriptylineapprovedunknowntransportersubstrateDetails
MeperidineapprovedunknowntransportersubstrateDetails
Pentazocineapproved, vet_approvedunknowntransportersubstrateDetails
Propofolapproved, investigational, vet_approvedunknowntransporterinducerDetails
EverolimusapprovedunknowntransportersubstrateinhibitorDetails
CeftriaxoneapprovedunknowntransporterinhibitorDetails
Conivaptanapproved, investigationalunknowntransporterinhibitorDetails
Salinomycinvet_approvedunknowntransporterinhibitorDetails
Zonisamideapproved, investigationalunknowntransporterinhibitorDetails
ValinomycinexperimentalunknowntransportersubstrateinhibitorDetails
Flibanserinapproved, investigationalunknowntransporterinhibitorDetails
Eliglustatapproved, investigationalnotransportersubstrateinhibitorDetails
BicalutamideapprovedunknowntransporterinhibitorDetails
MitotaneapprovedunknowntransporterinhibitorDetails
Lonafarnibapproved, investigationalnotransportersubstrateinhibitorDetails
TipifarnibinvestigationalunknowntransporterinhibitorDetails
Netupitantapproved, investigationalunknowntransporterinhibitorDetails
Suvorexantapproved, investigationalunknowntransporterDetails
VorapaxarapprovedunknowntransporterDetails
VandetanibapprovedunknowntransporterinhibitorDetails
Concanamycin AexperimentalunknowntransporterinhibitorDetails
HycanthoneexperimentalunknowntransporterinhibitorDetails
VemurafenibapprovedunknowntransportersubstrateinhibitorDetails
DexverapamilexperimentalunknowntransporterinhibitorDetails
EmopamilexperimentalunknowntransporterinhibitorDetails
LomerizineexperimentalunknowntransporterinhibitorDetails
TetrandrineexperimentalunknowntransporterinhibitorDetails
ONT-093investigationalunknowntransporterinhibitorDetails
Dofequidarexperimental, investigationalunknowntransporterinhibitorDetails
Medroxyprogesterone acetateapproved, investigationalunknowntransporterinhibitorDetails
Rimegepantapproved, investigationalunknowntransportersubstrateDetails
Favipiravirapproved, investigationalunknowntransporterinhibitorDetails
MedrysoneapprovedunknowntransportersubstrateDetails
Methylene blueapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ozanimodapproved, investigationalunknowntransportersubstrateDetails
Fingolimodapproved, investigationalnotransporterinhibitorDetails
Chloramphenicol succinateapprovedunknowntransportersubstrateDetails
Selumetinibapproved, investigationalunknowntransportersubstrateDetails
Prednisolone phosphateapproved, vet_approvedunknowntransportersubstrateinducerDetails
Tucatinibapproved, investigationalunknowntransportersubstrateDetails
Pemigatinibapproved, investigationalnotransportersubstrateinhibitorDetails
Zolmitriptanapproved, investigationalnotransporterDetails
Remdesivirapproved, investigationalunknowntransportersubstrateDetails
Capmatinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ixabepiloneapproved, investigationalunknowntransportersubstrateinhibitorDetails
Selpercatinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
RipretinibapprovedunknowntransportersubstrateinhibitorDetails
Clofazimineapproved, investigationalunknowntransportersubstrateinhibitorDetails
EmpagliflozinapprovedunknowntransportersubstrateDetails
CethromycininvestigationalunknowntransportersubstrateinhibitorDetails
GalantamineapprovednotransporterinhibitorDetails
Aliskirenapproved, investigationalnotransportersubstrateDetails
Artesunateapproved, investigationalunknowntransportersubstrateDetails
Bortezomibapproved, investigationalnotransportersubstrateDetails
Betamethasone phosphateapproved, vet_approvedunknowntransportersubstrateinducerDetails
Lurbinectedinapproved, investigationalunknowntransportersubstrateinhibitorDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknowntransportersubstrateinhibitorinducerDetails
Octreotideapproved, investigationalunknowntransportersubstrateDetails
Fostemsavirapproved, investigationalunknowntransportersubstrateDetails
Belantamab mafodotinapprovedunknowntransportersubstrateDetails
Risdiplamapproved, investigationalunknowntransportersubstrateDetails
Pralsetinibapproved, investigationalnotransportersubstrateinhibitorDetails
Filgotinibapproved, investigationalunknowntransportersubstrateDetails
BerotralstatapprovednotransportersubstrateinhibitorDetails
Relugolixapproved, investigationalunknowntransportersubstrateinhibitorDetails
Vibegronapproved, investigationalnotransportersubstrateDetails
Cortisone acetateapproved, investigationalunknowntransportersubstrateinducerDetails
Opicaponeapproved, investigationalnotransportersubstrateDetails
Vericiguatapproved, investigationalunknowntransportersubstrateDetails
Cabotegravirapproved, investigationalunknowntransportersubstrateDetails
Voclosporinapproved, investigationalunknowntransportersubstrateinhibitorDetails
Tepotinibapproved, investigationalnotransportersubstrateinhibitorDetails
Somatotropinapproved, investigationalunknowntransportersubstrateDetails
Alfuzosinapproved, investigationalunknowntransportersubstrateDetails
Trilaciclibapproved, investigationalunknowntransportersubstrateDetails
Umbralisibapproved, investigational, withdrawnunknowntransporterinhibitorDetails
Sulpirideapproved, investigationalunknowntransportersubstrateDetails
Temozolomideapproved, investigationalnotransportersubstrateDetails
AvanafilapprovedunknowntransportersubstrateDetails
Tivozanibapproved, investigationalunknowntransportersubstrateDetails
Daptomycinapproved, investigationalnotransportersubstrateDetails
Amisulprideapproved, investigationalnotransportersubstrateDetails
Diosminapproved, investigationalunknowntransporterinhibitorDetails
Vildagliptinapproved, investigationalnotransportersubstrateDetails
Azilsartan medoxomilapproved, investigationalnotransporterinhibitorDetails
Sapropterinapproved, investigationalunknowntransporterinhibitorDetails
Levoketoconazoleapproved, investigationalnotransporterinhibitorDetails
Loncastuximab tesirineapproved, investigationalunknowntransportersubstrateDetails
Sotorasibapproved, investigationalunknowntransporterinhibitorDetails
Infigratinibapproved, investigationalnotransportersubstrateinhibitorDetails
Ibrexafungerpapproved, investigationalunknowntransportersubstratetransporterDetails
Belumosudilapproved, investigationalnotransportersubstrateinhibitorDetails
Odevixibatapproved, investigationalunknowntransportersubstrateDetails
Belzutifanapproved, investigationalnotransportersubstrateDetails
Lonapegsomatropinapproved, investigationalunknowntransportersubstrateDetails
Mobocertinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Tisotumab vedotinapprovednotransportersubstrateDetails
Atogepantapproved, investigationalnotransportersubstrateDetails
RiociguatapprovednotransportersubstrateDetails
Avacopanapproved, investigationalnotransportersubstrateDetails
Asciminibapproved, investigationalnotransportersubstrateinhibitorDetails
Maribavirapproved, investigationalnotransporterinhibitorDetails
Nirmatrelvirapproved, investigationalnotransportersubstrateinhibitorDetails
Sotagliflozinapproved, investigationalnotransporterinhibitorDetails
Abrocitinibapproved, investigationalunknowntransporterinhibitorDetails
Mitapivatapproved, investigationalnotransportersubstrateinhibitorDetails
Cannabidiolapproved, investigationalnotransporterinhibitorDetails
Cannabinolexperimental, investigationalunknowntransporterinhibitorDetails
Medical Cannabisexperimental, investigationalunknowntransporterinhibitorDetails
Pacritinibapproved, investigationalnotransporterinhibitorDetails
Cariprazineapproved, investigationalunknowntransporterinhibitorDetails
AzvudineinvestigationalunknowntargetactivatorregulatorDetails
SAR-405838investigationalnotransportersubstrateDetails
VerapamilapprovedunknowntargetinhibitorblockerDetails
StiripentolapprovedunknowntransporterinhibitorDetails
Pirfenidoneapproved, investigationalunknowntransporterinhibitorDetails
Baloxavir marboxilapproved, investigationalunknowntransportersubstrateinhibitorDetails
Lenacapavirapproved, investigationalnotransportersubstrateDetails
Deucravacitinibapproved, investigationalunknowntransportersubstrateDetails
Telotristat ethylapproved, investigationalnotransportersubstrateinhibitorDetails
Futibatinibapproved, investigationalnotransportersubstrateinhibitorDetails
Vonoprazanapproved, investigationalunknowntransporterinhibitorDetails
Niraparibapproved, investigationalnotransportersubstrateDetails
Mirvetuximab soravtansineapproved, investigationalnotransportersubstrateDetails
Olutasidenibapproved, investigationalnotransporterinhibitorDetails
Polatuzumab vedotinapproved, investigationalnotransportersubstrateDetails
Adagrasibapproved, investigationalunknowntransporterinhibitorDetails
Bexagliflozinapproved, investigationalunknowntransportersubstrateDetails
Pirtobrutinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Elacestrantapproved, investigationalunknowntransporterinhibitorDetails
Midazolamapproved, illicitnotransportersubstrateDetails
Sparsentanapproved, investigationalunknowntransportersubstrateinhibitorDetails
Zavegepantapproved, investigationalunknowntransportersubstrateDetails
Leniolisibapproved, investigationalnotransportersubstrateDetails
Aripiprazoleapproved, investigationalunknowntransporterinhibitorDetails
VilanterolapprovednotransportersubstrateDetails
Quizartinibapproved, investigationalnotransportersubstrateinhibitorDetails
Momelotinibapproved, investigationalunknowntransportersubstrateDetails
Encorafenibapproved, investigationalnotransportersubstrateinhibitorDetails
Gefapixantapproved, investigationalnotransportersubstrateDetails
Binimetinibapproved, investigationalnotransportersubstrateDetails
Repotrectinibapproved, investigationalnotransportersubstrateinhibitorDetails
Nirogacestatapproved, investigationalnotransportersubstrateinhibitorDetails
Aprocitentanapproved, investigationalnotransportersubstrateDetails
Danicopanapproved, investigationalnotransporterinhibitorDetails
Mavorixaforapproved, investigationalunknowntransportersubstrateinhibitorDetails
Cladribineapproved, investigationalunknowntransportersubstrateDetails
DeuruxolitinibinvestigationalunknowntransportersubstrateDetails
Seladelparapproved, investigationalunknowntransportersubstrateDetails
BiricodarinvestigationalyestargetmodulatorDetails
Ixazomibapproved, investigationalunknowntransportersubstrateDetails
L-Acetylleucineapproved, investigationalnotransporterinhibitorDetails
BenzgalantamineapprovednotransporterinhibitorDetails