Glycoprotein

Details

Name
Glycoprotein
Synonyms
Not Available
Gene Name
G
Organism
Rabies virus (strain Pasteur vaccins / PV)
Amino acid sequence
>lcl|BSEQ0052123|Glycoprotein
MVPQALLFVPLLVFPLCFGKFPIYTIPDKLGPWSPIDIHHLSCPNNLVVEDEGCTNLSGF
SYMELKVGYISAIKMNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWK
MAGDPRYEESLHNPYPDYHWLRTVKTTKESLVIISPSVADLDPYDRSLHSRVFPGGNCSG
VAVSSTYCSTNHDYTIWMPENPRLGMSCDIFTNSRGKRASKGSETCGFVDERGLYKSLKG
ACKLKLCGVLGLRLMDGTWVAMQTSNETKWCPPGQLVNLHDFRSDEIEHLVVEELVKKRE
ECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPS
KGCLRVGGRCHPHVNGVFFNGIILGPDGNVLIPEMQSSLLQQHMELLVSSVIPLMHPLAD
PSTVFKNGDEAEDFVEVHLPDVHERISGVDLGLPNWGKYVLLSAGALTALMLIIFLMTCW
RRVNRSEPTQHNLRGTGREVSVTPQSGKIISSWESYKSGGETGL
Number of residues
524
Molecular Weight
58534.885
Theoretical pI
Not Available
GO Classification
Components
integral component of membrane / viral envelope / virion membrane
General Function
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
460-480
Cellular Location
Virion membrane
Gene sequence
>lcl|BSEQ0052124|Glycoprotein (G)
ATGGTTCCTCAGGCTCTCCTGTTTGTACCCCTTCTGGTTTTTCCATTGTGTTTTGGGAAA
TTCCCTATTTACACGATACCAGACAAGCTTGGTCCCTGGAGCCCGATTGACATACATCAC
CTCAGCTGCCCAAACAATTTGGTAGTGGAGGACGAAGGATGCACCAACCTGTCAGGGTTC
TCCTACATGGAACTTAAAGTTGGATACATCTCAGCCATAAAAATGAACGGGTTCACTTGC
ACAGGCGTTGTGACGGAGGCTGAAACCTACACTAACTTCGTTGGTTATGTCACAACCACG
TTCAAAAGAAAGCATTTCCGCCCAACACCAGATGCATGTAGAGCCGCGTACAACTGGAAG
ATGGCCGGTGACCCCAGATATGAAGAGTCTCTACACAATCCGTACCCTGACTACCACTGG
CTTCGAACTGTAAAAACCACCAAGGAGTCTCTCGTTATCATATCTCCAAGTGTGGCAGAT
TTGGACCCATATGACAGATCCCTTCACTCGAGGGTCTTCCCTGGCGGGAATTGCTCAGGA
GTAGCGGTGTCTTCTACCTACTGCTCCACTAACCACGATTACACCATTTGGATGCCCGAG
AATCCGAGACTAGGGATGTCTTGTGACATTTTTACCAATAGTAGAGGGAAGAGAGCATCC
AAAGGGAGTGAGACTTGCGGCTTTGTAGATGAAAGAGGCCTATATAAGTCTTTAAAAGGA
GCATGCAAACTCAAGTTATGTGGAGTTCTAGGACTTAGACTTATGGATGGAACATGGGTC
GCGATGCAAACATCAAATGAAACCAAATGGTGCCCTCCCGGTCAGTTGGTGAATTTGCAC
GACTTTCGCTCAGACGAAATTGAGCACCTTGTTGTAGAGGAGTTGGTCAAGAAGAGAGAG
GAGTGTCTGGATGCACTAGAGTCCATCATGACCACCAAGTCAGTGAGTTTCAGACGTCTC
AGTCATTTAAGAAAACTTGTCCCTGGGTTTGGAAAAGCATATACCATATTCAACAAGACC
TTGATGGAAGCCGATGCTCACTACAAGTCAGTCAGAACTTGGAATGAGATCATCCCTTCA
AAAGGGTGTTTAAGAGTTGGGGGGAGGTGTCATCCTCATGTAAACGGGGTATTTTTCAAT
GGTATAATATTAGGACCTGACGGCAATGTCTTAATCCCAGAGATGCAATCATCCCTCCTC
CAGCAACATATGGAGTTGTTGGTATCCTCGGTTATCCCCCTTATGCACCCCCTGGCAGAC
CCGTCTACCGTTTTCAAGAACGGTGACGAGGCTGAGGATTTTGTTGAAGTTCACCTTCCC
GATGTGCACGAACGGATCTCAGGAGTTGACTTGGGTCTCCCGAACTGGGGGAAGTATGTA
TTACTGAGTGCAGGGGCCCTGACTGCCTTGATGTTGATAATTTTCCTGATGACATGCTGG
AGAAGAGTCAATCGATCGGAACCTACACAACACAATCTCAGAGGGACAGGGAGGGAGGTG
TCAGTCACTCCCCAAAGCGGGAAGATCATATCTTCATGGGAATCATACAAGAGCGGGGGT
GAGACCGGACTGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP08667
UniProtKB Entry NameGLYCO_RABVP
General References
  1. Tordo N, Poch O, Ermine A, Keith G, Rougeon F: Walking along the rabies genome: is the large G-L intergenic region a remnant gene? Proc Natl Acad Sci U S A. 1986 Jun;83(11):3914-8. doi: 10.1073/pnas.83.11.3914. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11603Rabies immune globulin, humanapprovedyesantibodyDetails