Interleukin-6 receptor subunit alpha

Details

Name
Interleukin-6 receptor subunit alpha
Synonyms
  • gp80
  • IL-6 receptor subunit alpha
  • IL-6R 1
  • Membrane glycoprotein 80
Gene Name
IL6R
Organism
Humans
Amino acid sequence
>lcl|BSEQ0005598|Interleukin-6 receptor subunit alpha
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS
CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV
PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD
PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSS
SVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRP
TPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR
Number of residues
468
Molecular Weight
51547.015
Theoretical pI
8.3
GO Classification
Functions
ciliary neurotrophic factor binding / enzyme binding / interleukin-6 binding / interleukin-6 receptor activity / protein homodimerization activity
Processes
acute-phase response / cell growth / ciliary neurotrophic factor-mediated signaling pathway / cytokine-mediated signaling pathway / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / endocrine pancreas development / extrinsic apoptotic signaling pathway / hepatic immune response / interleukin-6-mediated signaling pathway / monocyte chemotaxis / negative regulation of collagen biosynthetic process / negative regulation of interleukin-8 production / neutrophil mediated immunity / positive regulation of activation of Janus kinase activity / positive regulation of cell proliferation / positive regulation of chemokine production / positive regulation of interleukin-6 production / positive regulation of leukocyte chemotaxis / positive regulation of MAPK cascade / positive regulation of osteoblast differentiation / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of smooth muscle cell proliferation / positive regulation of tyrosine phosphorylation of Stat3 protein / response to cAMP / response to cytokine / response to ethanol / response to gamma radiation / response to glucocorticoid / response to lipopolysaccharide / response to peptide hormone
Components
apical plasma membrane / basolateral plasma membrane / cell surface / ciliary neurotrophic factor receptor complex / extracellular region / extracellular space / interleukin-6 receptor complex / neuronal cell body membrane / plasma membrane
General Function
Protein homodimerization activity
Specific Function
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Pfam Domain Function
Transmembrane Regions
366-386
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0019340|Interleukin-6 receptor subunit alpha (IL6R)
ATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTG
GCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGA
GACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGG
GTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGG
CTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGC
CGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCC
TGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCA
TCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGAC
TTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTC
CCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGC
AAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCC
AACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGAC
CCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAA
CGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCAC
GACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAA
GGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGT
CCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGCACTTACTACTAATAAAGACGAT
GATAATATTCTCTTCAGAGATTCTGCAAATGCGACAAGCCTCCCAGTGCAAGATTCTTCT
TCAGTACCACTGCCCACATTCCTGGTTGCTGGAGGGAGCCTGGCCTTCGGAACGCTCCTC
TGCATTGCCATTGTTCTGAGGTTCAAGAAGACGTGGAAGCTGCGGGCTCTGAAGGAAGGC
AAGACAAGCATGCATCCGCCGTACTCTTTGGGGCAGCTGGTCCCGGAGAGGCCTCGACCC
ACCCCAGTGCTTGTTCCTCTCATCTCCCCACCGGTGTCCCCCAGCAGCCTGGGGTCTGAC
AATACCTCGAGCCACAACCGACCAGATGCCAGGGACCCACGGAGCCCTTATGACATCAGC
AATACAGACTACTTCTTCCCCAGATAG
Chromosome Location
1
Locus
1q21
External Identifiers
ResourceLink
UniProtKB IDP08887
UniProtKB Entry NameIL6RA_HUMAN
GenBank Gene IDX12830
GenAtlas IDIL6R
HGNC IDHGNC:6019
General References
  1. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988 Aug 12;241(4867):825-8. [Article]
  2. Schooltink H, Stoyan T, Lenz D, Schmitz H, Hirano T, Kishimoto T, Heinrich PC, Rose-John S: Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3):659-64. [Article]
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  8. Novick D, Engelmann H, Wallach D, Rubinstein M: Soluble cytokine receptors are present in normal human urine. J Exp Med. 1989 Oct 1;170(4):1409-14. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06273TocilizumabapprovedyesinhibitorantibodyDetails
DB11767Sarilumabapproved, investigationalyesantagonistantibodyDetails
DB15762SatralizumabapprovedyesbinderantibodyDetails