Calmodulin-2

Details

Name
Calmodulin-2
Synonyms
  • CAM2
  • CAMB
Gene Name
CALM2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051310|Calmodulin-2
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Number of residues
149
Molecular Weight
16837.47
Theoretical pI
Not Available
GO Classification
Functions
calcium channel inhibitor activity / calcium ion binding
Processes
negative regulation of ryanodine-sensitive calcium-release channel activity
Components
cytoplasm / spindle pole
General Function
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).
Specific Function
Calcium channel inhibitor activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Chromosome Location
14
Locus
14q32.11
External Identifiers
ResourceLink
UniProtKB IDP0DP24
UniProtKB Entry NameCALM2_HUMAN
HGNC IDHGNC:1445
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11093Calcium citrateapproved, investigationalunknownagonistDetails
DB11348Calcium PhosphateapprovedunknownagonistDetails
DB14481Calcium phosphate dihydrateapprovedunknownDetails