Retinoic acid receptor alpha

Details

Name
Retinoic acid receptor alpha
Synonyms
  • NR1B1
  • Nuclear receptor subfamily 1 group B member 1
  • RAR-alpha
Gene Name
RARA
UniProtKB Entry
P10276Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001322|Retinoic acid receptor alpha
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Number of residues
462
Molecular Weight
50770.805
Theoretical pI
7.95
GO Classification
Functions
chromatin binding / DNA-binding transcription factor activity / DNA-binding transcription factor activity, RNA polymerase II-specific / DNA-binding transcription repressor activity / heterocyclic compound binding / histone deacetylase binding / mRNA 5'-UTR binding / mRNA regulatory element binding translation repressor activity / nuclear receptor activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / sequence-specific double-stranded DNA binding / signaling receptor binding / transcription coactivator binding
Processes
cell differentiation / female pregnancy / hippocampus development / hormone-mediated signaling pathway / liver development / mRNA transcription by RNA polymerase II / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / negative regulation of miRNA transcription / negative regulation of transcription by RNA polymerase II / negative regulation of type II interferon production / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription / positive regulation of neuron differentiation / positive regulation of transcription by RNA polymerase II / prostate gland development / regulation of apoptotic process / regulation of hematopoietic progenitor cell differentiation / regulation of myelination / regulation of synaptic plasticity / response to cytokine / response to estradiol / response to ethanol / response to vitamin A
Components
chromatin / cytosol / nucleolus / perinuclear region of cytoplasm / plasma membrane / protein-containing complex / RNA polymerase II transcription regulator complex / transcription regulator complex
General Function
Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758, PubMed:37478846, PubMed:21152046). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:9267036, PubMed:37478846). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758)
Specific Function
alpha-actinin binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016168|Retinoic acid receptor alpha (RARA)
ATGGCCAGCAACAGCAGCTCCTGCCCGACACCTGGGGGCGGGCACCTCAATGGGTACCCG
GTGCCTCCCTACGCCTTCTTCTTCCCCCCTATGCTGGGTGGACTCTCCCCGCCAGGCGCT
CTGACCACTCTCCAGCACCAGCTTCCAGTTAGTGGATATAGCACACCATCCCCAGCCACC
ATTGAGACCCAGAGCAGCAGTTCTGAAGAGATAGTGCCCAGCCCTCCCTCGCCACCCCCT
CTACCCCGCATCTACAAGCCTTGCTTTGTCTGTCAGGACAAGTCCTCAGGCTACCACTAT
GGGGTCAGCGCCTGTGAGGGCTGCAAGGGCTTCTTCCGCCGCAGCATCCAGAAGAACATG
GTGTACACGTGTCACCGGGACAAGAACTGCATCATCAACAAGGTGACCCGGAACCGCTGC
CAGTACTGCCGACTGCAGAAGTGCTTTGAAGTGGGCATGTCCAAGGAGTCTGTGAGAAAC
GACCGAAACAAGAAGAAGAAGGAGGTGCCCAAGCCCGAGTGCTCTGAGAGCTACACGCTG
ACGCCGGAGGTGGGGGAGCTCATTGAGAAGGTGCGCAAAGCGCACCAGGAAACCTTCCCT
GCCCTCTGCCAGCTGGGCAAATACACTACGAACAACAGCTCAGAACAACGTGTCTCTCTG
GACATTGACCTCTGGGACAAGTTCAGTGAACTCTCCACCAAGTGCATCATTAAGACTGTG
GAGTTCGCCAAGCAGCTGCCCGGCTTCACCACCCTCACCATCGCCGACCAGATCACCCTC
CTCAAGGCTGCCTGCCTGGACATCCTGATCCTGCGGATCTGCACGCGGTACACGCCCGAG
CAGGACACCATGACCTTCTCGGACGGGCTGACCCTGAACCGGACCCAGATGCACAACGCT
GGCTTCGGCCCCCTCACCGACCTGGTCTTTGCCTTCGCCAACCAGCTGCTGCCCCTGGAG
ATGGATGATGCGGAGACGGGGCTGCTCAGCGCCATCTGCCTCATCTGCGGAGACCGCCAG
GACCTGGAGCAGCCGGACCGGGTGGACATGCTGCAGGAGCCGCTGCTGGAGGCGCTAAAG
GTCTACGTGCGGAAGCGGAGGCCCAGCCGCCCCCACATGTTCCCCAAGATGCTAATGAAG
ATTACTGACCTGCGAAGCATCAGCGCCAAGGGGGCTGAGCGGGTGATCACGCTGAAGATG
GAGATCCCGGGCTCCATGCCGCCTCTCATCCAGGAAATGTTGGAGAACTCAGAGGGCCTG
GACACTCTGAGCGGACAGCCGGGGGGTGGGGGGCGGGACGGGGGTGGCCTGGCCCCCCCG
CCAGGCAGCTGTAGCCCCAGCCTCAGCCCCAGCTCCAACAGAAGCAGCCCGGCCACCCAC
TCCCCGTGA
Chromosome Location
17
Locus
17q21.2
External Identifiers
ResourceLink
UniProtKB IDP10276
UniProtKB Entry NameRARA_HUMAN
GenBank Protein ID36157
GenBank Gene IDX06614
GeneCard IDRARA
GenAtlas IDRARA
HGNC IDHGNC:9864
PDB ID(s)1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13, 6XWG, 7AOS, 7APO, 7QAA, 7WQQ
KEGG IDhsa:5914
IUPHAR/Guide To Pharmacology ID590
NCBI Gene ID5914
General References
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Associated Data

Bio-Entities
Bio-EntityType
Retinoic acid receptor alpha (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
AcitretinapprovedyestargetagonistDetails
Alitretinoinapproved, investigationalyestargetagonistDetails
Tazaroteneapproved, investigationalyestargetagonistDetails
EtretinatewithdrawnyestargetagonistDetails
Isotretinoinapprovedunknowntargetagonistother/unknownDetails
TamibaroteneinvestigationalyestargetagonistDetails
LGD-1550investigationalunknowntargetDetails
Tretinoinapproved, investigational, nutraceuticalyestargetagonistDetails
Trifaroteneapproved, investigationalunknowntargetagonistDetails
AdapaleneapprovedunknowntargetDetails
LG-100268experimentalyestargetagonistDetails
IRX-5183investigationalyestargetagonistDetails