Serine/threonine-protein kinase B-raf

Details

Name
Serine/threonine-protein kinase B-raf
Synonyms
  • 2.7.11.1
  • BRAF1
  • p94
  • Proto-oncogene B-Raf
  • RAFB1
  • v-Raf murine sarcoma viral oncogene homolog B1
Gene Name
BRAF
UniProtKB Entry
P15056Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001264|Serine/threonine-protein kinase B-raf
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Number of residues
766
Molecular Weight
84436.135
Theoretical pI
7.58
GO Classification
Functions
MAP kinase kinase activity / mitogen-activated protein kinase kinase binding / protein serine kinase activity / protein-containing complex binding / scaffold protein binding
Processes
animal organ morphogenesis / CD4-positive or CD8-positive, alpha-beta T cell lineage commitment / cellular response to nerve growth factor stimulus / cellular response to xenobiotic stimulus / endothelial cell apoptotic process / ERK1 and ERK2 cascade / face development / positive regulation of glucose transmembrane transport / regulation of cell population proliferation / regulation of T cell differentiation / response to peptide hormone / stress fiber assembly / substrate adhesion-dependent cell spreading / synaptic vesicle exocytosis / T cell differentiation in thymus / T cell receptor signaling pathway / thymus development / thyroid gland development
Components
presynapse
General Function
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
Specific Function
ATP binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0020477|Serine/threonine-protein kinase B-raf (BRAF)
ATGGCGGCGCTGAGCGGTGGCGGTGGTGGCGGCGCGGAGCCGGGCCAGGCTCTGTTCAAC
GGGGACATGGAGCCCGAGGCCGGCGCCGGCGCCGGCGCCGCGGCCTCTTCGGCTGCGGAC
CCTGCCATTCCGGAGGAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACAT
ATAGAGGCCCTATTGGACAAATTTGGTGGGGAGCATAATCCACCATCAATATATCTGGAG
GCCTATGAAGAATACACCAGCAAGCTAGATGCACTCCAACAAAGAGAACAACAGTTATTG
GAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCTGCATCAATGGATACCGTT
ACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCTTCATCTCTTTCAGTTTTTCAAAAT
CCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCTTC
CTGCCCAACAAACAGAGGACAGTGGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGT
CTAAAGAAAGCACTGATGATGAGAGGTCTAATCCCAGAGTGCTGTGCTGTTTACAGAATT
CAGGATGGAGAGAAGAAACCAATTGGTTGGGACACTGATATTTCCTGGCTTACTGGAGAA
GAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACACACAACTTTGTACGAAAA
ACGTTTTTCACCTTAGCATTTTGTGACTTTTGTCGAAAGCTGCTTTTCCAGGGTTTCCGC
TGTCAAACATGTGGTTATAAATTTCACCAGCGTTGTAGTACAGAAGTTCCACTGATGTGT
GTTAATTATGACCAACTTGATTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATA
CCACAGGAAGAGGCGTCCTTAGCAGAGACTGCCCTAACATCTGGATCATCCCCTTCCGCA
CCCGCCTCGGACTCTATTGGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCATT
CCAATTCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGA
GACCGATCCTCATCAGCTCCCAATGTGCATATAAACACAATAGAACCTGTCAATATTGAT
GACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCT
ACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCA
GGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACA
CTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGA
CAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTG
GCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAAT
GAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCC
ACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCAT
CTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACT
GCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAAT
AATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTG
AAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATG
GCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATAT
GCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAAC
AACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAG
GTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAA
AGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCA
TTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACA
GAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATAT
GGTGCGTTTCCTGTCCACTGA
Chromosome Location
7
Locus
7q34
External Identifiers
ResourceLink
UniProtKB IDP15056
UniProtKB Entry NameBRAF_HUMAN
GenBank Protein ID41387220
GenBank Gene IDM95712
GeneCard IDBRAF
GenAtlas IDBRAF
HGNC IDHGNC:1097
PDB ID(s)1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4CQE, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ, 4MNE, 4MNF, 4PP7, 4R5Y, 4RZV, 4RZW, 4WO5, 4XV1, 4XV2, 4XV3, 4XV9, 4YHT, 5C9C, 5CSW, 5CSX, 5CT7, 5FD2, 5HI2, 5HID, 5HIE, 5ITA, 5J17, 5J18, 5J2R, 5JRQ, 5JSM, 5JT2, 5VAL, 5VAM, 5VR3, 5VYK, 6B8U, 6CAD, 6N0P, 6N0Q, 6NSQ, 6NYB, 6P3D, 6P7G, 6PP9, 6Q0J, 6Q0K, 6Q0T, 6U2G, 6U2H, 6UAN, 6UUO, 6V2U, 6V2W, 6V34, 6XAG, 6XFP, 6XLO, 7K0V, 7M0T, 7M0U, 7M0V, 7M0W, 7M0X, 7M0Y, 7M0Z, 7MFD, 7MFE, 7MFF, 7P3V, 7SHV, 7ZR0, 7ZR5, 7ZR6, 8C7X, 8C7Y, 8DGS, 8DGT, 8F7O, 8F7P, 8QQG, 9AXX, 9AXY
KEGG IDhsa:673
IUPHAR/Guide To Pharmacology ID1943
NCBI Gene ID673
General References
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Associated Data

Bio-Entities
Bio-EntityType
Serine/threonine-protein kinase B-raf (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Sorafenibapproved, investigationalyestargetinhibitorDetails
XL281investigationalunknowntargetDetails
RAF-265investigationalunknowntargetDetails
PLX-4720experimentalyestargetinhibitorDetails
N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamideexperimentalunknowntargetDetails
(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oximeexperimentalunknowntargetDetails
VemurafenibapprovedyestargetinhibitorDetails
RegorafenibapprovedyestargetinhibitorDetails
Dabrafenibapproved, investigationalyestargetinhibitorDetails
Fostamatinibapproved, investigationalunknowntargetinhibitorDetails
Encorafenibapproved, investigationalyestargetinhibitorDetails
RipretinibapprovedyestargetinhibitorDetails
BMS-908662investigationalyestargetinhibitorDetails
LifirafenibinvestigationalyestargetinhibitorDetails
AgerafenibinvestigationalyestargetinhibitorDetails
AvutometinibinvestigationalyestargetmodulatorDetails
PLX8394investigationalyestargetinhibitorDetails
Tovorafenibapproved, investigationalyestargetinhibitorDetails