Tyrosine-protein phosphatase YopH
Details
- Name
- Tyrosine-protein phosphatase YopH
- Synonyms
- 3.1.3.48
- Virulence protein
- yop51
- Gene Name
- yopH
- Organism
- Yersinia enterocolitica
- Amino acid sequence
>lcl|BSEQ0010943|Tyrosine-protein phosphatase YopH MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVL SHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAA LRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARA TAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAV RADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPD YFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAV SSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMN DSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
- Number of residues
- 468
- Molecular Weight
- 50939.075
- Theoretical pI
- 8.84
- GO Classification
- Functionsprotein tyrosine phosphatase activityProcessespathogenesisComponentsextracellular region
- General Function
- Protein tyrosine phosphatase activity
- Specific Function
- Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010944|Tyrosine-protein phosphatase YopH (yopH) ATGAACTTATCATTAAGCGATCTTCATCGTCAGGTATCTCGATTGGTGCAGCAAGAGAGC GGTGATTGTACCGGGAAATTAAGAGGTAACGTTGCTGCCAATAAAGAAACTACCTTTCAA GGTTTGACCATAGCCAGTGGTGCCAGAGAGTCAGAAAAAGTATTTGCTCAAACTGTACTA AGCCACGTAGCAAATATTGTTCTAACTCAAGAAGATACCGCTAAGCTATTGCAAAGCACG GTAAAGCATAATTTGAATAATTATGAATTAAGAAGTGTCGGCAATGGTAATAGTGTACTT GTCAGTTTACGTAGTGACCAAATGACACTACAAGACGCCAAAGTGCTGTTGGAGGCTGCA TTGCGACAAGAGTCGGGAGCGAGGGGGCATGTATCATCTCATTCACATTCAGTCCTTCAC GCACCGGGAACCCCGGTGCGTGAAGGACTGCGTTCACATCTAGACCCCAGAACACCACCG TTGCCACCGCGTGAACGACCACACACTTCTGGCCATCACGGGGCTGGCGAAGCCAGAGCC ACCGCACCAAGCACTGTTTCTCCTTATGGCCCAGAAGCGCGCGCAGAACTCAGCAGCCGC CTCACCACATTGCGCAATACGCTGGCGCCAGCAACGAATGATCCGCGTTACTTACAAGCC TGCGGCGGTGAAAAGCTAAACCGATTTAGAGATATTCAATGCTGTCGGCAAACCGCAGTA CGCGCCGATCTTAATGCCAATTACATCCAGGTCGGTAACACTCGTACCATAGCGTGCCAG TATCCGCTACAATCTCAACTTGAAAGCCATTTCCGTATGCTGGCAGAAAACCGAACGCCA GTGTTGGCTGTTTTAGCGTCCAGTTCTGAGATAGCCAATCAAAGATTCGGTATGCCAGAT TATTTCCGCCAGAGTGGTACCTATGGCAGTATCACTGTAGAGTCTAAAATGACTCAGCAA GTTGGTCTCGGTGACGGGATTATGGCAGATATGTATACTTTAACGATTCGTGAAGCGGGT CAAAAAACAATTTCTGTTCCTGTGGTTCATGTTGGCAATTGGCCCGATCAGACCGCAGTC AGCTCTGAAGTTACCAAGGCACTCGCTTCACTGGTAGATCAAACAGCAGAAACAAAACGC AATATGTATGAAAGCAAAGGAAGTTCAGCGGTAGCAGATGACTCCAAATTACGGCCGGTA ATACATTGCCGTGCGGGTGTTGGCCGTACTGCGCAACTGATTGGCGCAATGTGCATGAAT GATAGTCGTAATAGTCAGTTAAGCGTAGAAGATATGGTCAGCCAAATGCGAGTACAAAGA AATGGTATTATGGTACAAAAAGATGAGCAACTTGATGTTCTGATTAAGTTGGCTGAAGGA CAAGGGCGACCATTATTAAATAGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P15273 UniProtKB Entry Name YOPH_YEREN - General References
- Michiels T, Cornelis G: Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703. Microb Pathog. 1988 Dec;5(6):449-59. [Article]
- Guan KL, Dixon JE: Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 1990 Aug 3;249(4968):553-6. [Article]
- Zhang ZY, Clemens JC, Schubert HL, Stuckey JA, Fischer MW, Hume DM, Saper MA, Dixon JE: Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase. J Biol Chem. 1992 Nov 25;267(33):23759-66. [Article]
- Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, Saper MA: Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature. 1994 Aug 18;370(6490):571-5. [Article]
- Fauman EB, Yuvaniyama C, Schubert HL, Stuckey JA, Saper MA: The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications. J Biol Chem. 1996 Aug 2;271(31):18780-8. [Article]