Inosine-5'-monophosphate dehydrogenase 1
Details
- Name
- Inosine-5'-monophosphate dehydrogenase 1
- Synonyms
- 1.1.1.205
- IMP dehydrogenase 1
- IMPD 1
- IMPD1
- IMPDH 1
- IMPDH-I
- Gene Name
- IMPDH1
- UniProtKB Entry
- P20839Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0001518|Inosine-5'-monophosphate dehydrogenase 1 MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
- Number of residues
- 514
- Molecular Weight
- 55405.365
- Theoretical pI
- 6.9
- GO Classification
- FunctionsDNA binding / IMP dehydrogenase activity / metal ion binding / nucleic acid binding / RNA bindingProcessesGMP biosynthetic processComponentscytoplasm / cytosol / nucleus
- General Function
- Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
- Specific Function
- DNA binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010537|Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) ATGGAGGGGCCACTCACTCCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAG CCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTACAGCGCCCGACTG CTGCAGGCCGGCTACGAGCCCGAGAGCCCTAGATTGGACCTCGCTACACACCCGACGACA CCCCGTTCAGAACTATCTTCAGTGGTCTTACTGGCAGGTGTTGGTGTCCAGATGGATCGC CTTCGCAGGGCTAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAG GATGGGCTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTC CTGATTCTCCCAGGATTCATAGACTTCATAGCTGATGAGGTGGACCTGACCTCAGCCCTG ACCCGGAAGATCACGCTGAAGACGCCACTGATCTCCTCCCCCATGGACACTGTGACAGAG GCTGACATGGCCATTGCCATGGCTCTGATGGGAGGTATTGGTTTCATTCACCACAACTGC ACCCCAGAGTTCCAGGCCAACGAGGTGCGGAAGGTCAAGAAGTTTGAACAGGGCTTCATC ACGGACCCTGTGGTGCTGAGCCCCTCGCACACTGTGGGCGATGTGCTGGAGGCCAAGATG CGGCATGGCTTCTCTGGCATCCCCATCACTGAGACGGGCACCATGGGCAGCAAGCTGGTG GGCATCGTCACCTCCCGAGACATCGACTTTCTTGCTGAGAAGGACCACACCACCCTCCTC AGTGAGGTGATGACGCCAAGGATTGAACTGGTGGTGGCTCCAGCAGGTGTGACGTTGAAA GAGGCAAATGAGATCCTGCAGCGTAGCAAGAAAGGGAAGCTGCCTATCGTCAATGATTGC GATGAGCTGGTGGCCATCATCGCCCGCACCGACCTGAAGAAGAACCGAGACTACCCTCTG GCCTCCAAGGATTCCCAGAAGCAGCTGCTCTGTGGGGCAGCTGTGGGCACCCGTGAGGAT GACAAATACCGTCTGGACCTGCTCACCCAGGCGGGCGTCGACGTCATAGTCTTGGACTCG TCCCAAGGGAATTCGGTGTATCAGATCGCCATGGTGCATTACATCAAACAGAAGTACCCC CACCTCCAGGTGATTGGGGGGAACGTGGTGACAGCAGCCCAGGCCAAGAACCTGATTGAT GCTGGTGTGGACGGGCTGCGCGTGGGCATGGGCTGCGGCTCCATCTGCATCACCCAGGAA GTGATGGCCTGTGGTCGGCCCCAGGGCACTGCTGTGTACAAGGTGGCTGAGTATGCCCGG CGCTTTGGTGTGCCCATCATAGCCGATGGCGGCATCCAGACCGTGGGACACGTGGTCAAG GCCCTGGCCCTTGGAGCCTCCACAGTGATGATGGGCTCCCTGCTGGCCGCCACTACGGAG GCCCCTGGCGAGTACTTCTTCTCAGACGGGGTGCGGCTCAAGAAGTACCGGGGCATGGGC TCACTGGATGCCATGGAGAAGAGCAGCAGCAGCCAGAAACGATACTTCAGCGAGGGGGAT AAAGTGAAGATCGCGCAGGGTGTCTCGGGCTCCATCCAGGACAAAGGATCCATTCAGAAG TTCGTGCCCTACCTCATAGCAGGCATCCAACACGGCTGCCAGGATATCGGGGCCCGCAGC CTGTCTGTCCTTCGGTCCATGATGTACTCAGGAGAGCTCAAGTTTGAGAAGCGGACCATG TCGGCCCAGATTGAGGGTGGTGTCCATGGCCTGCACTCTTACGAAAAGCGGCTGTACTGA
- Chromosome Location
- 7
- Locus
- 7q32.1
- External Identifiers
Resource Link UniProtKB ID P20839 UniProtKB Entry Name IMDH1_HUMAN GenBank Protein ID 307067 GenBank Gene ID J05272 GeneCard ID IMPDH1 GenAtlas ID IMPDH1 HGNC ID HGNC:6052 PDB ID(s) 1JCN, 7RER, 7RES, 7RFE, 7RFF, 7RFG, 7RFH, 7RFI, 7RGD, 7RGI, 7RGL, 7RGM, 7RGQ, 8U7M, 8U7Q, 8U7V, 8U8O, 8U8Y KEGG ID hsa:3614 IUPHAR/Guide To Pharmacology ID 2624 NCBI Gene ID 3614 - General References
- Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K: Two distinct cDNAs for human IMP dehydrogenase. J Biol Chem. 1990 Mar 25;265(9):5292-5. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Inosine-5'-monophosphate dehydrogenase 1 (Humans) protein primaryInosine-5'-monophosphate dehydrogenase (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details NADH approved, nutraceutical unknown target Details Mycophenolate mofetil approved, investigational yes target inhibitorinducer Details Ribavirin approved yes target inhibitor Details Mycophenolic acid approved, investigational yes target inhibitor Details 6-Chloropurine Riboside, 5'-Monophosphate experimental unknown target Details VX-148 investigational unknown target Details Taribavirin investigational yes target inhibitor Details Azathioprine approved unknown enzyme substrate Details Inosinic Acid experimental yes target inhibitor Details Hadacidin experimental yes target inhibitor Details Phenacetin withdrawn yes target inhibitor Details Mercaptopurine approved yes target inhibitor Details Mizoribine investigational yes target inhibitor Details Tiazofurine experimental yes target inhibitor Details Merimepodib investigational yes target inhibitor Details Mercaptopurine approved unknown target inhibitor Details