Thromboxane A2 receptor
Details
- Name
- Thromboxane A2 receptor
- Synonyms
- Prostanoid TP receptor
- TXA2-R
- Gene Name
- TBXA2R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037068|Thromboxane A2 receptor MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
- Number of residues
- 343
- Molecular Weight
- 37430.69
- Theoretical pI
- 10.31
- GO Classification
- Functionsguanyl-nucleotide exchange factor activity / thromboxane A2 receptor activityProcessesblood coagulation / G-protein coupled receptor signaling pathway / inflammatory response / platelet activation / positive regulation of angiogenesis / positive regulation of blood pressure / positive regulation of cytosolic calcium ion concentration / positive regulation of GTPase activity / positive regulation of smooth muscle contraction / positive regulation of vasoconstriction / response to drug / response to lipopolysaccharide / response to nutrient / second-messenger-mediated signaling / thromboxane A2 signaling pathwayComponentsacrosomal vesicle / cytosol / integral component of plasma membrane / plasma membrane
- General Function
- Thromboxane a2 receptor activity
- Specific Function
- Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 30-52 67-87 107-128 150-172 194-219 247-270 290-311
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019006|Thromboxane A2 receptor (TBXA2R) ATGTGGCCCAACGGCAGTTCCCTGGGGCCCTGTTTCCGGCCCACAAACATTACCCTGGAG GAGAGACGGCTGATCGCCTCGCCCTGGTTCGCCGCCTCCTTCTGCGTGGTGGGCCTGGCC TCCAACCTGCTGGCCCTGAGCGTGCTGGCGGGCGCGCGGCAGGGGGGTTCGCACACGCGC TCCTCCTTCCTCACCTTCCTCTGCGGCCTCGTCCTCACCGACTTCCTGGGGCTGCTGGTG ACCGGTACCATCGTGGTGTCCCAGCACGCCGCGCTCTTCGAGTGGCACGCCGTGGACCCT GGCTGCCGTCTCTGTCGCTTCATGGGCGTCGTCATGATCTTCTTCGGCCTGTCCCCGCTG CTGCTGGGGGCCGCCATGGCCTCAGAGCGCTACCTGGGTATCACCCGGCCCTTCTCGCGC CCGGCGGTCGCCTCGCAGCGCCGCGCCTGGGCCACCGTGGGGCTGGTGTGGGCGGCCGCG CTGGCGCTGGGCCTGCTGCCCCTGCTGGGCGTGGGTCGCTACACCGTGCAATACCCGGGG TCCTGGTGCTTCCTGACGCTGGGCGCCGAGTCCGGGGACGTGGCCTTCGGGCTGCTCTTC TCCATGCTGGGCGGCCTCTCGGTCGGGCTGTCCTTCCTGCTGAACACGGTCAGCGTGGCC ACCCTGTGCCACGTCTACCACGGGCAGGAGGCGGCCCAGCAGCGTCCCCGGGACTCCGAG GTGGAGATGATGGCTCAGCTCCTGGGGATCATGGTGGTGGCCAGCGTGTGTTGGCTGCCC CTTCTGGTCTTCATCGCCCAGACAGTGCTGCGAAACCCGCCTGCCATGAGCCCCGCCGGG CAGCTGTCCCGCACCACGGAGAAGGAGCTGCTCATCTACTTGCGCGTGGCCACCTGGAAC CAGATCCTGGACCCCTGGGTGTATATCCTGTTCCGCCGCGCCGTGCTCCGGCGTCTCCAG CCTCGCCTCAGCACCCGGCCCAGGTCGCTGTCCCTCCAGCCCCAGCTCACGCAGCGCTCC GGGCTGCAGTAG
- Chromosome Location
- 19
- Locus
- 19p13.3
- External Identifiers
Resource Link UniProtKB ID P21731 UniProtKB Entry Name TA2R_HUMAN GenBank Protein ID 533326 GenBank Gene ID D38081 GenAtlas ID TBXA2R HGNC ID HGNC:11608 - General References
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