Fibroblast growth factor receptor 2
Details
- Name
- Fibroblast growth factor receptor 2
- Synonyms
- 2.7.10.1
- BEK
- FGFR-2
- K-sam
- Keratinocyte growth factor receptor
- KGFR
- KSAM
- Gene Name
- FGFR2
- UniProtKB Entry
- P21802Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0001492|Fibroblast growth factor receptor 2 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
- Number of residues
- 821
- Molecular Weight
- 92024.29
- Theoretical pI
- 5.68
- GO Classification
- FunctionsATP binding / fibroblast growth factor binding / fibroblast growth factor-activated receptor activity / heparin binding / protein homodimerization activity / protein tyrosine kinase activityProcessesactivation of MAPKK activity / angiogenesis / apoptotic process / axon guidance / axonogenesis / bone development / bone mineralization / bone morphogenesis / branch elongation involved in salivary gland morphogenesis / branching involved in labyrinthine layer morphogenesis / branching involved in prostate gland morphogenesis / branching involved in salivary gland morphogenesis / branching morphogenesis of a nerve / bud elongation involved in lung branching / cell fate commitment / cell-cell signaling / coronal suture morphogenesis / digestive tract development / embryonic cranial skeleton morphogenesis / embryonic digestive tract morphogenesis / embryonic organ development / embryonic organ morphogenesis / embryonic pattern specification / endodermal digestive tract morphogenesis / epidermal growth factor receptor signaling pathway / epidermis morphogenesis / epithelial cell differentiation / epithelial cell proliferation involved in salivary gland morphogenesis / epithelial to mesenchymal transition / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor signaling pathway involved in hemopoiesis / fibroblast growth factor receptor signaling pathway involved in mammary gland specification / fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow / fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development / fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow / gland morphogenesis / hair follicle morphogenesis / in utero embryonic development / innate immune response / inner ear morphogenesis / insulin receptor signaling pathway / lacrimal gland development / lateral sprouting from an epithelium / lens fiber cell development / limb bud formation / lung alveolus development / lung development / lung lobe morphogenesis / lung-associated mesenchyme development / mammary gland bud formation / MAPK cascade / membranous septum morphogenesis / mesenchymal cell differentiation / mesenchymal cell differentiation involved in lung development / mesenchymal cell proliferation involved in lung development / mesodermal cell differentiation / midbrain development / morphogenesis of embryonic epithelium / multicellular organism growth / negative regulation of epithelial cell proliferation / negative regulation of mitotic nuclear division / negative regulation of transcription from RNA polymerase II promoter / neuromuscular junction development / neurotrophin TRK receptor signaling pathway / odontogenesis / orbitofrontal cortex development / organ growth / organ morphogenesis / otic vesicle formation / outflow tract septum morphogenesis / peptidyl-tyrosine phosphorylation / phosphatidylinositol-mediated signaling / positive regulation of canonical Wnt signaling pathway / positive regulation of cardiac muscle cell proliferation / positive regulation of cell cycle / positive regulation of cell division / positive regulation of cell proliferation / positive regulation of epithelial cell proliferation / positive regulation of epithelial cell proliferation involved in lung morphogenesis / positive regulation of ERK1 and ERK2 cascade / positive regulation of MAPK cascade / positive regulation of mesenchymal cell proliferation / positive regulation of phospholipase activity / positive regulation of smooth muscle cell proliferation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of Wnt signaling pathway / post-embryonic development / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / prostate epithelial cord elongation / prostate gland morphogenesis / protein autophosphorylation / pyramidal neuron development / Ras protein signal transduction / regulation of branching involved in prostate gland morphogenesis / regulation of cell fate commitment / regulation of ERK1 and ERK2 cascade / regulation of fibroblast growth factor receptor signaling pathway / regulation of morphogenesis of a branching structure / regulation of multicellular organism growth / regulation of osteoblast differentiation / regulation of osteoblast proliferation / regulation of smooth muscle cell differentiation / regulation of smoothened signaling pathway / reproductive structure development / skeletal system morphogenesis / small GTPase mediated signal transduction / squamous basal epithelial stem cell differentiation involved in prostate gland acinus development / synaptic vesicle transport / ureteric bud development / vascular endothelial growth factor receptor signaling pathway / ventricular cardiac muscle tissue morphogenesis / ventricular zone neuroblast divisionComponentscell cortex / cell surface / cytoplasm / cytoplasmic membrane-bounded vesicle / excitatory synapse / extracellular region / Golgi apparatus / integral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / membrane / nucleoplasm / nucleus / plasma membrane
- General Function
- Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
- Specific Function
- ATP binding
- Pfam Domain Function
- Not Available
- Signal Regions
- 1-21
- Transmembrane Regions
- 378-398
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010527|Fibroblast growth factor receptor 2 (FGFR2) ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTG GCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGG CCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCG GAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAG GAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCC GGACTGCCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTT TACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACG GACAAAGAGATTGAGGTTCTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATAT ACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATT TACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATG AAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA CGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCC AACACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTG GCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAG CTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCA GTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAA GATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATG ATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTC TATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGG CCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTC AAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAA AAATGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATG AAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACC ACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATAC ACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGG GGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACAC AGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGG CATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATT CTCACTCTCACAACCAATGAGGAATACTTGGACCTCAGCCAACCTCTCGAACAGTATTCA CCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCA GACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAA ACATGA
- Chromosome Location
- 10
- Locus
- 10q26
- External Identifiers
Resource Link UniProtKB ID P21802 UniProtKB Entry Name FGFR2_HUMAN GenBank Protein ID 31374 GenBank Gene ID X52832 GenAtlas ID FGFR2 HGNC ID HGNC:3689 PDB ID(s) 1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J23, 4J95, 4J96, 4J97, 4J98, 4J99, 4WV1 KEGG ID hsa:2263 IUPHAR/Guide To Pharmacology ID 1809 NCBI Gene ID 2263 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Fibroblast growth factor receptor 2 (Humans) protein primaryFibroblast growth factor receptor (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Palifermin approved yes target agonistbinder Details 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine experimental unknown target Details 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone experimental unknown target Details Regorafenib approved yes target inhibitor Details Ponatinib approved, investigational unknown target inhibitor Details Lenvatinib approved, investigational yes target inhibitor Details Nintedanib approved yes target inhibitor Details Sucrosofate experimental unknown target ligand Details Heparin approved, investigational unknown target Details Foreskin fibroblast (neonatal) approved unknown target agonist Details Foreskin keratinocyte (neonatal) approved unknown target agonist Details Fostamatinib approved, investigational unknown target inhibitor Details Erdafitinib approved, investigational yes target inhibitor Details Pemigatinib approved, investigational yes target inhibitor Details Selpercatinib approved, investigational unknown target inhibitor Details Pralsetinib approved, investigational unknown target inhibitor Details Infigratinib approved, investigational yes target inhibitor Details Futibatinib approved, investigational yes target inhibitor Details KIN-3248 investigational yes target inhibitor Details AEE-788 investigational yes target inhibitor Details DEBIO-1347 investigational yes target inhibitor Details LY-2874455 investigational yes target modulator Details Lucitanib investigational yes target inhibitor Details