CD9 antigen
Details
- Name
- CD9 antigen
- Synonyms
- 5H9 antigen
- Cell growth-inhibiting gene 2 protein
- Leukocyte antigen MIC3
- MIC3
- Motility-related protein
- MRP-1
- p24
- Tetraspanin-29
- Tspan-29
- TSPAN29
- Gene Name
- CD9
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012360|CD9 antigen MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGV YILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKE VQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKS CPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
- Number of residues
- 228
- Molecular Weight
- 25415.835
- Theoretical pI
- 7.19
- GO Classification
- Processesblood coagulation / brain development / cell adhesion / cell surface receptor signaling pathway / cellular response to low-density lipoprotein particle stimulus / fusion of sperm to egg plasma membrane / movement of cell or subcellular component / multicellular organism reproduction / negative regulation of cell proliferation / oligodendrocyte development / paranodal junction assembly / platelet activation / platelet degranulation / receptor internalization / response to water deprivation / single fertilizationComponentsapical plasma membrane / clathrin-coated endocytic vesicle membrane / endocytic vesicle membrane / external side of plasma membrane / extracellular exosome / extracellular space / extracellular vesicle / focal adhesion / integral component of plasma membrane / membrane / plasma membrane / platelet alpha granule membrane
- General Function
- Not Available
- Specific Function
- Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.
- Pfam Domain Function
- Tetraspanin (PF00335)
- Transmembrane Regions
- 13-33 56-76 88-111 196-221
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0012361|CD9 antigen (CD9) ATGCCGGTCAAAGGAGGCACCAAGTGCATCAAATACCTGCTGTTCGGATTTAACTTCATC TTCTGGCTTGCCGGGATTGCTGTCCTTGCCATTGGACTATGGCTCCGATTCGACTCTCAG ACCAAGAGCATCTTCGAGCAAGAAACTAATAATAATAATTCCAGCTTCTACACAGGAGTC TATATTCTGATCGGAGCCGGCGCCCTCATGATGCTGGTGGGCTTCCTGGGCTGCTGCGGG GCTGTGCAGGAGTCCCAGTGCATGCTGGGACTGTTCTTCGGCTTCCTCTTGGTGATATTC GCCATTGAAATAGCTGCGGCCATCTGGGGATATTCCCACAAGGATGAGGTGATTAAGGAA GTCCAGGAGTTTTACAAGGACACCTACAACAAGCTGAAAACCAAGGATGAGCCCCAGCGG GAAACGCTGAAAGCCATCCACTATGCGTTGAACTGCTGTGGTTTGGCTGGGGGCGTGGAA CAGTTTATCTCAGACATCTGCCCCAAGAAGGACGTACTCGAAACCTTCACCGTGAAGTCC TGTCCTGATGCCATCAAAGAGGTCTTCGACAATAAATTCCACATCATCGGCGCAGTGGGC ATCGGCATTGCCGTGGTCATGATATTTGGCATGATCTTCAGTATGATCTTGTGCTGTGCT ATCCGCAGGAACCGCGAGATGGTCTAG
- Chromosome Location
- 12
- Locus
- 12p13.3
- External Identifiers
Resource Link UniProtKB ID P21926 UniProtKB Entry Name CD9_HUMAN GenBank Gene ID S60489 GenAtlas ID CD9 HGNC ID HGNC:1709 - General References
- Boucheix C, Benoit P, Frachet P, Billard M, Worthington RE, Gagnon J, Uzan G: Molecular cloning of the CD9 antigen. A new family of cell surface proteins. J Biol Chem. 1991 Jan 5;266(1):117-22. [Article]
- Lanza F, Wolf D, Fox CF, Kieffer N, Seyer JM, Fried VA, Coughlin SR, Phillips DR, Jennings LK: cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J Biol Chem. 1991 Jun 5;266(16):10638-45. [Article]
- Miyake M, Koyama M, Seno M, Ikeyama S: Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. J Exp Med. 1991 Dec 1;174(6):1347-54. [Article]
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- Ikeyama S, Koyama M, Yamaoko M, Sasada R, Miyake M: Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med. 1993 May 1;177(5):1231-7. [Article]
- Masellis-Smith A, Shaw AR: CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin. J Immunol. 1994 Mar 15;152(6):2768-77. [Article]
- Higginbottom A, Takahashi Y, Bolling L, Coonrod SA, White JM, Partridge LJ, Monk PN: Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion. Biochem Biophys Res Commun. 2003 Nov 7;311(1):208-14. [Article]
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- Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E: The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. J Biol Chem. 2001 Apr 27;276(17):14329-37. Epub 2001 Jan 18. [Article]
- Stipp CS, Kolesnikova TV, Hemler ME: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001 Nov 2;276(44):40545-54. Epub 2001 Aug 14. [Article]
- Israels SJ, McMillan-Ward EM: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets. Thromb Res. 2010 Feb;125(2):152-8. doi: 10.1016/j.thromres.2009.07.005. Epub 2009 Jul 29. [Article]
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