Potassium voltage-gated channel subfamily A member 5
Details
- Name
- Potassium voltage-gated channel subfamily A member 5
- Synonyms
- HPCN1
- Voltage-gated potassium channel HK2
- Voltage-gated potassium channel subunit Kv1.5
- Gene Name
- KCNA5
- UniProtKB Entry
- P22460Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0008568|Potassium voltage-gated channel subfamily A member 5 MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL YALCLDTSRETDL
- Number of residues
- 613
- Molecular Weight
- 67227.15
- Theoretical pI
- Not Available
- GO Classification
- Functionssignaling receptor binding / voltage-gated potassium channel activityProcessesaction potential / membrane repolarization during atrial cardiac muscle cell action potential / potassium ion export across plasma membraneComponentscell surface / membrane
- General Function
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:12130714, PubMed:8505626). Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets
- Specific Function
- alpha-actinin binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 248-269 324-345 357-377 396-416 432-453 495-523
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017518|Potassium voltage-gated channel subfamily A member 5 (KCNA5) ATGGAGATCGCCCTGGTGCCCCTGGAGAACGGCGGTGCCATGACCGTCAGAGGAGGCGAT GAGGCCCGGGCAGGCTGCGGCCAGGCCACAGGGGGAGAGCTCCAGTGTCCCCCGACGGCT GGGCTCAGCGATGGGCCCAAGGAGCCGGCGCCAAAGGGGCGCGGCGCGCAGAGAGACGCG GACTCGGGAGTGCGGCCCTTGCCTCCGCTGCCGGACCCGGGAGTGCGGCCCTTGCCTCCG CTGCCAGAGGAGCTGCCACGGCCTCGACGGCCGCCTCCCGAGGACGAGGAGGAAGAAGGC GATCCCGGCCTGGGCACGGTGGAGGACCAGGCTCTGGGCACGGCGTCCCTGCACCACCAG CGCGTCCACATCAACATCTCCGGGCTGCGCTTTGAGACGCAGCTGGGCACCCTGGCGCAG TTCCCCAACACACTCCTGGGGGACCCCGCCAAGCGCCTGCGCTACTTCGACCCCCTGAGG AACGAGTACTTCTTCGACCGCAACCGGCCCAGCTTCGACGGTATCCTCTACTACTACCAG TCCGGGGGCCGCCTGCGGAGGCCGGTCAACGTCTCCCTGGACGTGTTCGCGGACGAGATA CGCTTCTACCAGCTGGGGGACGAGGCCATGGAGCGCTTCCGCGAGGATGAGGGCTTCATT AAAGAAGAGGAGAAGCCCCTGCCCCGCAACGAGTTCCAGCGCCAGGTGTGGCTTATCTTC GAGTATCCGGAGAGCTCTGGGTCCGCGCGGGCCATCGCCATCGTCTCGGTCTTGGTTATC CTCATCTCCATCATCACCTTCTGCTTGGAGACCCTGCCTGAGTTCAGGGATGAACGTGAG CTGCTCCGCCACCCTCCGGCGCCCCACCAGCCTCCCGCGCCCGCCCCTGGGGCCAACGGC AGCGGGGTCATGGCCCCGCCCTCTGGCCCTACGGTGGCACCGCTCCTGCCCAGGACCCTG GCCGACCCCTTCTTCATCGTGGAGACCACGTGCGTCATCTGGTTCACCTTCGAGCTGCTC GTGCGCTTCTTCGCCTGCCCCAGCAAGGCAGGGTTCTCCCGGAACATCATGAACATCATC GATGTGGTGGCCATCTTCCCCTACTTCATCACCCTGGGCACCGAACTGGCAGAGCAGCAG CCAGGGGGTGGAGGAGGCGGCCAGAATGGGCAGCAGGCCATGTCCCTGGCCATCCTCCGA GTCATCCGCCTGGTCCGGGTGTTCCGCATCTTCAAGCTCTCCCGCCACTCCAAGGGGCTG CAGATCCTGGGCAAGACCTTGCAGGCCTCCATGAGGGAGCTGGGGCTGCTCATCTTCTTC CTCTTCATCGGGGTCATCCTCTTCTCCAGTGCCGTCTACTTCGCAGAGGCTGACAACCAG GGAACCCATTTCTCTAGCATCCCTGACGCCTTCTGGTGGGCAGTGGTCACCATGACCACT GTGGGCTACGGGGACATGAGGCCCATCACTGTTGGGGGCAAGATCGTGGGCTCGCTGTGT GCCATCGCCGGGGTCCTCACCATTGCCCTGCCTGTGCCCGTCATCGTCTCCAACTTCAAC TACTTCTACCACCGGGAAACGGATCACGAGGAGCCGGCAGTCCTTAAGGAAGAGCAGGGC ACTCAGAGCCAGGGGCCGGGGCTGGACAGAGGAGTCCAGCGGAAGGTCAGCGGGAGCAGG GGATCCTTCTGCAAGGCTGGGGGGACCCTGGAGAATGCAGACAGTGCCCGAAGGGGCAGC TGCCCCCTAGAGAAGTGTAACGTCAAGGCCAAGAGCAACGTGGACTTGCGGAGGTCCCTT TATGCCCTCTGCCTGGACACCAGCCGGGAAACAGATTTGTGA
- Chromosome Location
- 12
- Locus
- 12p13.32
- External Identifiers
Resource Link UniProtKB ID P22460 UniProtKB Entry Name KCNA5_HUMAN GeneCard ID KCNA5 HGNC ID HGNC:6224 KEGG ID hsa:3741 IUPHAR/Guide To Pharmacology ID 542 NCBI Gene ID 3741 - General References
- Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM: Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J. 1991 Mar 1;5(3):331-7. [Article]
- Philipson LH, Hice RE, Schaefer K, LaMendola J, Bell GI, Nelson DJ, Steiner DF: Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):53-7. [Article]
- Curran ME, Landes GM, Keating MT: Molecular cloning, characterization, and genomic localization of a human potassium channel gene. Genomics. 1992 Apr;12(4):729-37. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Snyders DJ, Tamkun MM, Bennett PB: A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. J Gen Physiol. 1993 Apr;101(4):513-43. [Article]
- Kurata HT, Soon GS, Fedida D: Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5. J Gen Physiol. 2001 Sep;118(3):315-32. [Article]
- Williams CP, Hu N, Shen W, Mashburn AB, Murray KT: Modulation of the human Kv1.5 channel by protein kinase C activation: role of the Kvbeta1.2 subunit. J Pharmacol Exp Ther. 2002 Aug;302(2):545-50. [Article]
- Mathur R, Choi WS, Eldstrom J, Wang Z, Kim J, Steele DF, Fedida D: A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. Biochem Biophys Res Commun. 2006 Mar 31;342(1):1-8. Epub 2006 Jan 31. [Article]
- Olson TM, Alekseev AE, Liu XK, Park S, Zingman LV, Bienengraeber M, Sattiraju S, Ballew JD, Jahangir A, Terzic A: Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Hum Mol Genet. 2006 Jul 15;15(14):2185-91. Epub 2006 Jun 13. [Article]
- Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iniguez-Lluhi JA, Martens JR: SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1805-10. Epub 2007 Jan 29. [Article]
- Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Potassium voltage-gated channel subfamily A member 5 (Humans) protein primaryVoltage-gated Potassium Channels protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dalfampridine approved yes target antagonist Details Vernakalant approved, investigational yes target blocker Details Isavuconazole approved, investigational no target inhibitor Details Tetraethylammonium experimental, investigational yes target blocker Details BMS-919373 investigational yes target inhibitor Details Dronedarone approved yes target blocker Details Enflurane approved, investigational, vet_approved unknown target inhibitoractivator Details Promethazine approved, investigational unknown target inducer Details Miconazole approved, investigational, vet_approved unknown target inhibitor Details