Carbonic anhydrase 4
Details
- Name
- Carbonic anhydrase 4
- Synonyms
- 4.2.1.1
- CA-IV
- Carbonate dehydratase IV
- Carbonic anhydrase IV
- Gene Name
- CA4
- UniProtKB Entry
- P22748Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0001068|Carbonic anhydrase 4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG PMLACLLAGFLR
- Number of residues
- 312
- Molecular Weight
- 35032.075
- Theoretical pI
- 7.94
- GO Classification
- Componentsexternal side of plasma membrane
- General Function
- Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17652713, PubMed:17705204, PubMed:18618712, PubMed:19186056, PubMed:19206230, PubMed:7625839). May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis (PubMed:15563508). It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid (PubMed:15563508)
- Specific Function
- carbonate dehydratase activity
- Pfam Domain Function
- Carb_anhydrase (PF00194)
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010374|Carbonic anhydrase 4 (CA4) ATGCGGATGCTGCTGGCGCTCCTGGCCCTCTCCGCGGCGCGGCCATCGGCCAGTGCAGAG TCACACTGGTGCTACGAGGTTCAAGCCGAGTCCTCCAACTACCCCTGCTTGGTGCCAGTC AAGTGGGGTGGAAACTGCCAGAAGGACCGCCAGTCCCCCATCAACATCGTCACCACCAAG GCAAAGGTGGACAAAAAACTGGGACGCTTCTTCTTCTCTGGCTACGATAAGAAGCAAACG TGGACTGTCCAAAATAACGGGCACTCAGTGATGATGTTGCTGGAGAACAAGGCCAGCATT TCTGGAGGAGGACTGCCTGCCCCATACCAGGCCAAACAGTTGCACCTGCACTGGTCCGAC TTGCCATATAAGGGCTCGGAGCACAGCCTCGATGGGGAGCACTTTGCCATGGAGATGCAC ATAGTACATGAGAAAGAGAAGGGGACATCGAGGAATGTGAAAGAGGCCCAGGACCCTGAA GACGAAATTGCGGTGCTGGCCTTTCTGGTGGAGGCTGGAACCCAGGTGAACGAGGGCTTC CAGCCACTGGTGGAGGCACTGTCTAATATCCCCAAACCTGAGATGAGCACTACGATGGCA GAGAGCAGCCTGTTGGACCTGCTCCCCAAGGAGGAGAAACTGAGGCACTACTTCCGCTAC CTGGGCTCACTCACCACACCGACCTGCGATGAGAAGGTCGTCTGGACTGTGTTCCGGGAG CCCATTCAGCTTCACAGAGAACAGATCCTGGCATTCTCTCAGAAGCTGTACTACGACAAG GAACAGACAGTGAGCATGAAGGACAATGTCAGGCCCCTGCAGCAGCTGGGGCAGCGCACG GTGATAAAGTCCGGGGCCCCGGGTCGGCCGCTGCCCTGGGCCCTGCCTGCCCTGCTGGGC CCCATGCTGGCCTGCCTGCTGGCCGGCTTCCTGCGATGA
- Chromosome Location
- 17
- Locus
- 17q23.1
- External Identifiers
Resource Link UniProtKB ID P22748 UniProtKB Entry Name CAH4_HUMAN GenBank Protein ID 179791 GenBank Gene ID M83670 GeneCard ID CA4 GenAtlas ID CA4 HGNC ID HGNC:1375 PDB ID(s) 1ZNC, 3F7B, 3F7U, 3FW3, 5IPZ, 5JN8, 5JN9, 5JNA, 5JNC, 5KU6 KEGG ID hsa:762 IUPHAR/Guide To Pharmacology ID 2599 NCBI Gene ID 762 - General References
- Okuyama T, Sato S, Zhu XL, Waheed A, Sly WS: Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1315-9. [Article]
- Okuyama T, Batanian JR, Sly WS: Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q. Genomics. 1993 Jun;16(3):678-84. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Carbonic anhydrase 4 (Humans) protein primaryCarbonic anhydrase (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Methyclothiazide withdrawn unknown target inhibitor Details Topiramate approved yes target inhibitor Details Bendroflumethiazide approved unknown target inhibitor Details Benzthiazide approved unknown target inhibitor Details Hydroflumethiazide approved, investigational, withdrawn unknown target inhibitor Details Trichlormethiazide approved, vet_approved unknown target inhibitor Details Dorzolamide approved yes target inhibitor Details Zonisamide approved, investigational unknown target inhibitor Details Acetazolamide approved, vet_approved yes target inhibitor Details Ethoxzolamide withdrawn yes target inhibitor Details Methazolamide approved yes target inhibitor Details Diclofenamide approved, investigational yes target inhibitor Details Brinzolamide approved unknown target inhibitor Details Ellagic acid investigational yes target inhibitor Details Sodium carbonate approved unknown target inhibitor Details Ferulic acid experimental yes target inhibitor Details 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide experimental yes target inhibitor Details Sodium citrate approved, investigational yes target inhibitor Details Phenylboronic acid experimental yes target inhibitor Details Sodium phosphate, dibasic approved yes target inhibitor Details 4-(2-AMINOETHYL)BENZENESULFONAMIDE experimental yes target inhibitor Details Hexamethylene diamine experimental yes target inhibitor Details Cadaverine experimental yes target inhibitor Details p-Coumaric acid experimental yes target inhibitor Details 1,2-Dihydroxybenzene experimental yes target inhibitor Details Coumarin experimental yes target inhibitor Details Cianidanol approved, withdrawn yes target inhibitor Details Pyruvic acid approved, investigational, nutraceutical yes target inhibitor Details Curcumin approved, investigational yes target inhibitor Details Mafenide approved, vet_approved, withdrawn yes target inhibitor Details Salicylic acid approved, investigational, vet_approved yes target inhibitor Details Spermine experimental, nutraceutical yes target inhibitor Details Phenol approved, experimental yes target inhibitor Details Benzthiazide approved yes target inhibitor Details Cyclothiazide approved yes target inhibitor Details