Gentamicin 3-N-acetyltransferase

Details

Name
Gentamicin 3-N-acetyltransferase
Synonyms
  • 2.3.1.60
  • AAC(3)-I
  • Aminoglycoside N(3)-acetyltransferase I
  • Gentamicin acetyltransferase I
Gene Name
aacC1
Organism
Pseudomonas aeruginosa
Amino acid sequence
>lcl|BSEQ0022421|Gentamicin 3-N-acetyltransferase
MLRSSNDVTQQGSRPKTKLGGSSMGIIRTCRLGPDQVKSMRAALDLFGREFGDVATYSQH
QPDSDYLGNLLRSKTFIALAAFDQEAVVGALAAYVLPRFEQPRSEIYIYDLAVSGEHRRQ
GIATALINLLKHEANALGAYVIYVQADYGDDPAVALYTKLGIREEVMHFDIDPSTAT
Number of residues
177
Molecular Weight
19441.81
Theoretical pI
6.11
GO Classification
Functions
aminoglycoside 3-N-acetyltransferase activity
Processes
response to antibiotic
General Function
Aminoglycoside 3-n-acetyltransferase activity
Specific Function
Responsible for gentamicin resistance and has a limited substrate range.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0003868|534 bp
ATGTTACGCAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGT
GGCTCAAGTATGGGCATCATTCGCACATGTAGGCTCGGCCCTGACCAAGTCAAATCCATG
CGGGCTGCTCTTGATCTTTTCGGTCGTGAGTTCGGAGACGTAGCCACCTACTCCCAACAT
CAGCCGGACTCCGATTACCTCGGGAACTTGCTCCGTAGTAAGACATTCATCGCGCTTGCT
GCCTTCGACCAAGAAGCGGTTGTTGGCGCTCTCGCGGCTTACGTTCTGCCCAGGTTTGAG
CAGCCGCGTAGTGAGATCTATATCTATGATCTCGCAGTCTCCGGCGAGCACCGGAGGCAG
GGCATTGCCACCGCGCTCATCAATCTCCTCAAGCATGAGGCCAACGCGCTTGGTGCTTAT
GTGATCTACGTGCAAGCAGATTACGGTGACGATCCCGCAGTGGCTCTCTATACAAAGTTG
GGCATACGGGAAGAAGTGATGCACTTTGATATCGACCCAAGTACCGCCACCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP23181
UniProtKB Entry NameAACC1_PSEAI
GenBank Protein ID530805
GenBank Gene IDU12338
General References
  1. Wohlleben W, Arnold W, Bissonnette L, Pelletier A, Tanguay A, Roy PH, Gamboa GC, Barry GF, Aubert E, Davies J, et al.: On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette. Mol Gen Genet. 1989 Jun;217(2-3):202-8. [Article]
  2. Hsiang MW, White TJ, Davies JE: NH2-terminal sequence of the aminoglycoside acetyltransferase (3)-I mediated by plasmid RIP 135. FEBS Lett. 1978 Aug 1;92(1):97-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB03566SpermidineexperimentalunknownDetails